Bovine nodular skin disease is an infectious disease caused by bovine nodular skin disease virus infecting cattle. Beef cattle,Asian buffalo and dairy cows are susceptible.The disease is characterized by extensive skin nodules throughout the body,so it is also called bovine pimple skin disease.In addition to skin lesions,there may be fever,swollen lymph nodes on the body,mouth, nose and eye ulcers,nose and eyes accompanied There are clinical manifestations such as secretions,edema in limbs, abdomen, perineum and other parts.The mortality rate is low,but the morbidity is high,and the infection is strong,which seriously affects the growth,development and production of cattle.The disease was first reported in Yili,Xinjiang, my country in August 2019,and then epidemics of the disease were found in Fujian,Jiangxi,Guangdong and other places.The initial diagnosis of the disease can be made through clinical symptoms and epidemiological investigations, and the diagnosis requires laboratory diagnosis.The prevention and control of the disease in my country mainly adopts comprehensive prevention and control measures such as immunization,isolation,culling,and disinfection.