Clostridiosis Welchii in goats is an acute and toxic infectious disease caused by Clostridium Welchii. The disease occurs suddenly,the course of disease is short,there is often no time for treatment,and the mortality is high. Take three dead dairy goats in Fangzi District,Weifang City,Shandong Province as example,the clinical examination, epidemiological investigation,autopsy diagnosis and laboratory diagnosis are carried out, and make the definite diagnosis. This paper analyzed the pathogeny,put forward practical preventive measures,which has certain guiding significance for the treatment and prevention of the disease.