Bovine tuberculosis,brucellosis,foot-and-mouth disease and bovine nodular skin disease have become major and important infectious diseases that need to be focused on prevention and control in the process of cow breeding.This paper made a diagnosis from the epidemic characteristics,clinical symptoms,laboratory diagnostic methods,and other aspects of the above-mentioned diseases,and proposes measures for epidemic response.At the same time,it was proposed to pay attention to epidemic monitoring,purification,and quarantine supervision,develop reasonable immunization procedures,and correctly select vaccines for effective immunization,in order to provide safety guarantees for the sustainable development of the dairy farming industry and the physical health of the people.