[Objective] The incidence of cow's milk protein allergy （CMPA） in newborns is increasing recently. IgE mediated CMPA is more common in outpatient. Therefore,to find an alternative milk is another way for treatment of CMPA. This study aimed to compare the combination of serum IgE in newborns of different gestational ages with different milk. [Method] Serum of preterm infants and term infants were included,and breast milk,goat's formula milk and cow's formula milk were incubated with serum,respectively. ELISA was used to exam the serum IgE which was binded. [Result] The results showed that the combination of breast milk and IgE in term infants was significantly higher than that formula milk groups （P < 0.05）. In preterm infants,there was no significant difference in the binding of three different milk to IgE. The relative amount of IgE binding between cow's formula milk and serum of preterm infants was significantly higher than that of term infants （P < 0.05）,while there was no markedly difference in IgE binding between goat's formula milk and serum of preterm infants and that of term infants,as well as breast milk.[Conclusion] It suggested that goat's formula milk was more similar to breast milk in terms of IgE binding than cow's formula milk.
JIA Qiong, LU Danfang, TONG Xiaomei
. Comparison of IgE Binding between Different Kinds of Milk and Serum of Newborns with Different Gestational Ages[J]. China Dairy, 2023
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: 88
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DOI: 10.12377/1671-4393.23.10.16
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