Dairy cow paralysis is one of the common diseases caused by a variety of factors, such as unbalanced calcium and phosphorus ratio, negative blood calcium balance after pregnancy, rheumatoid arthritis, and so on. The paralysis of cows caused by the injection of foot-and-mouth disease (FMD) vaccine was an adverse reaction or allergic reaction after vaccination, and the feed intake of dairy cows decreases and they are bedridden. In this paper, a case of FMD-vaccine-induced paralysis in a dairy farmer in Lianyungang of Jiangsu province was investigated and clinically examined, the cause of the disease was analyzed, the treatment plan was proposed, and the feasible preventive measures were summarized, so as to provide reference for the prevention and control of the disease.