[Objective] To explore the efficacy of combined traditional Chinese and Western medicine in the treatment of mastitis in dairy goats,providing a basis for clinical application. [Method] A total of 10 healthy control goats and 20 goats with mastitis of similar body condition and parity were selected and randomly divided into two groups: the Western medicine treatment group （antibiotic treatment） and the combined treatment group （Gualou Powder + antibiotic treatment）. The therapeutic effects were recorded continuously until day 12. The milk yield of each group was recorded on days 1,4,7,and 12.The levels of alanine aminotransferase （ALT）,aspartate aminotransferase （AST）,lactate dehydrogenase （LDH）, and albumin （SA） in the whey were measured using a biochemical analyzer. The inflammatory factors IL-1β, IL-6, IL-8, and TNF-α, as well as antioxidant factors total antioxidant capacity （T-AOC）,glutathione peroxidase （GSH-Px）,catalase （CAT）, superoxide dismutase （SOD）,and malondialdehyde （MDA）,were detected using ELISA on days 1,4,7, and 12. [Results] On days 4 and 12,the milk yield of the combined treatment group was significantly higher than that of the Western medicine treatment group （P< 0.05）. On days 4,7,and 12,the levels of IL-1β,IL-6,IL-8,and TNF-α in the whey of the combined treatment group were significantly lower than those in the Western medicine treatment group （P< 0.05）. Additionally, on days 1,4,7,and 12, the levels of ALT, AST, LDH,and SA in the whey of the combined treatment group were significantly lower than those in the Western medicine treatment group （P< 0.05）. The MDA levels in the combined treatment group were significantly lower than those in the Western medicine treatment group on days 4,7,and 12（P< 0.05）. The levels of T-AOC,GSH Px,CAT,and SOD in whey of the combination treatment group were significantly higher than those of the Western medicine treatment group on days 4,7,and 12（P<0.05）,and MDA was significantly lower than that of the Western medicine treatment group （P<0.05）. [Conclusion] Gualou Powder combined with Western medicine effectively treats mastitis in dairy goats,enhances milk yield and antioxidant capacity,and alleviates inflammation.