To explore the strategy and effect of prevention and treatment of sheep infectious pustular dermatitis with traditional Chinese and Western medicine. [Method] Combination of traditional Chinese and western medicine: western medicine can resist secondary infection and treat local symptoms,while traditional Chinese medicine has broad-spectrum antivirus, overall conditioning and promote tissue regeneration. [Result] Western medicine therapy takes effect quickly but the overall adjustment is weak,while Chinese medicine therapy emphasizes the overall adjustment but takes effect relatively slowly.The combination of the two can complement each other,accelerate rehabilitation,reduce recurrence and reduce the use of antibiotics. [Conclusion] The organic combination of traditional Chinese and western medicine can synergize and improve the cure rate,which is an effective way to prevent and control the disease.