China Dairy ›› 2025, Vol. 0 ›› Issue (12): 36-42.doi: 10.12377/1671-4393.25.12.06

• DISEASE PREVENTION • Previous Articles     Next Articles

Treatment Approaches and Management Strategies for Bovine Mastitis

LIU Weihong1, FU Guangda1, WANG Guandong1, LI Xiaoming2   

  1. 1 Linyi Animal Disease Prevention and Control Center,Linyi Shandong 276000;
    2 Jiangsu Agri-animal Husbandry Vocational College,Taizhou Jiangsu 225300
  • Online:2025-12-25 Published:2026-01-14

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Abstract: Bovine mastitis is one of the most prevalent and economically damaging diseases in the dairy industry.It presents a complex pathogen spectrum,including gram-positive bacteria,gram-negative bacteria,and emerging atypical microorganisms,and exhibits distinct clinical classifications.With the escalating problem of drug resistance in dairy cow farming, traditional treatment models are facing challenges, and the diagnosis and treatment of mastitis are in urgent need of a transformation towards precision and diversification.This paper provided a comprehensive review of the pathogens associated with mastitis,its clinical classifications,and recent advances in molecular diagnostic techniques.It highlighted the current research status and application prospects of novel therapeutic strategies such as antibiotics,bacteriophages,antimicrobial peptides,probiotics,herbal medicine,immunotherapy,nanomaterials,and stem cell therapy.Furthermore,it integrated genetic selection,nutritional regulation,dry-off period management,and teat sealant use into a systematic framework for comprehensive mastitis prevention and control.The aim was to offer a theoretical and practical basis for early detection,effective control,and sustainable management of bovine mastitis,thereby promoting healthier and more efficient dairy farming systems.

Key words: bovine mastitis, pathogen spectrum, diagnostic advancement, alternative therapy, comprehensive control

[1] 马莉花,马学虎,王娜娜,等.奶牛肠源性乳腺炎发病机理及防控措施[J].家畜生态学报,2024,45(10):86-91.
[2] 胡晓宇,赵才军,曹永国,等.基于肠-乳腺轴浅谈奶牛“内源性乳腺炎”的病理机制及防控措施[J].中国兽医学报,2022,42(6):1287-1294.
[3] 曹佩佩,马学虎,李梦吉,等.代谢组学技术在筛选奶牛乳腺炎生物标志物中的应用[J].动物营养学报,2024,36(6):3474-3481.
[4] 曹海南,徐崇,赵静雯,等.2021年江苏省部分牧场奶牛临床型乳腺炎源病原菌的分离鉴定及地区、月份分布情况分析[J].黑龙江畜牧兽医,2023(12):81-86.
[5] 谢景昊,杨晨,杨涵琳,等.健康奶牛和乳腺炎奶牛乳汁中微生物组成的特征及差异研究[J].中国乳品工业,2024,52(4):10-19,60.
[6] 乔亚蕊,苗宇航,黄倩,等.奶牛乳腺炎源粪肠球菌生物学特性研究[J].畜牧兽医学报,2025,56(5):2325-2339.
[7] 范素菊,孙灵灵,王慧琴,等.中草药提取物治疗奶牛乳腺炎的研究进展[J/OL].中国草食动物科学,1-8[2025-03-22].
[8] 岳丽莎,武岳,吕雅琼,等.奶牛乳腺炎中凝固酶阴性葡萄球菌的分离鉴定及耐药性分析[J].中国奶牛,2024(7):51-55.
[9] 卢智奇,侯丽娥,吴非凡,等.奶牛乳腺炎的影响因素及防治措施研究进展[J].畜牧兽医杂志,2023,42(6):26-31.
[10] 赵晓明,夏露,王晓旭,等.应用噬菌体喷雾消毒剂防控细菌性奶牛乳腺炎[J].中国抗生素杂志,2024,49(10):1192-1201.
[11] 赵翠,赵效南,闫超,等.金黄色葡萄球菌噬菌体生物学特性研究[J].山东农业科学,2023,55(2):135-139.
[12] 耿慧君,张美霞,徐永平,等.噬菌体在奶牛乳腺炎防控中的应用[J].中国抗生素杂志,2017,42(9):724-730.
[13] 何静,马慧敏,马荣,等.抗菌肽对奶牛乳腺炎的防治作用及机制[J].中国畜牧杂志,2025,61(4):84-89.
[14] 高爽,童津津,姚华,等.抗菌肽在奶牛乳腺炎防治中的研究进展[J].动物营养学报,2023,35(9):5485-5495.
[15] 蔡云阁. 益生菌治疗奶牛乳腺炎的研究进展[J].中国乳业,2023(4):67-71.
[16] 张伟,朱怡萱,彭菲,等.雪白睡莲花活性成分对奶牛乳腺炎主要致病菌抑菌和抗炎作用研究[J].动物医学进展,2022,43(6):63-68.
[17] 张海艳,许顺鑫,陈秋慧,等.牛无绿藻乳腺炎的研究现状[J].动物医学进展,2023,44(1):122-126.
[18] 杨晴,蔡文锦.安石榴苷缓解金黄色葡萄球菌诱导奶牛乳腺炎的研究[J].黑龙江畜牧兽医,2021(1):127-133.
[19] 安彦昊,王德志,赵庆磊,等.核因子-κB在奶牛乳腺炎和子宫内膜炎中的作用机制[J].动物营养学报,2024,36(5):2773-2781.
[20] 鞠牧洁. 纳米凝胶提高盐酸沃尼妙林对奶牛乳源性金黄色葡萄球菌的治疗效果评价[D].阿拉尔:塔里木大学,2023.
[21] 冀中豪. 小鼠乳腺上皮细胞来源外泌体通过调控巨噬细胞M1型极化影响乳腺炎的分子机制[D].长春:吉林大学,2024.
[22] 王晋鹏,罗仍卓么,王兴平,等.奶牛乳腺炎治疗及抗炎分子机制的研究进展[J].生物技术通报,2021,37(12):212-219.
[23] 左佳坤,连丽燕,扶邵东,等.2020-2022年中国部分地区奶牛乳腺炎大肠杆菌分子流行病学研究[J/OL].中国动物传染病学报,1-12[2025-03-22].
[24] 任美奕,梁洪秀,李璨,等.基于不同ST型肺炎克雷伯菌感染的小鼠乳腺炎模型的差异分析[J].中国畜牧兽医,2025,52(1):422-431.
[25] 陆璐,张逸,陈志,等.茶树油及其成分对奶牛乳腺炎主要致病菌的抑菌效果[J].家畜生态学报,2023,44(5):71-76.
[26] 刘荣慧,寇茜茜,张伟,等.石河子地区奶牛临床型乳腺炎源葡萄球菌的分离鉴定与药敏试验[J].黑龙江畜牧兽医,2023(12):92-96,146-147.
[27] 金妍杉,刘红云.管理应激对奶牛泌乳性能的影响及其机制[J].中国畜牧杂志,2022,58(6):85-91.
[28] 徐红波,冀伟,赵功权,等.不同黏度次硝酸铋乳头封闭剂的特性及其栓塞封闭效果研究[J].中国奶牛,2024(9):48-51.
[29] 张泰彪,朱新荣,张财祯,等.乳头封闭剂和不同干奶药品对预防奶牛产后乳房炎的研究[J].中国乳业,2022(8):24-28.
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