Abstract: Carry out formula design and process research on the milk based fully nutritious liquid formula food for special medical purposes over the age of ten，and verify the stability of micronutrients within the shelf life of the product and the effect of human trial drinking．According to the general principles of formula foods for special medical purposes，the sources and contents of three energy supplying substances are determined，including protein 4.0 g/100 mL，fat 2.3 g/100 mL and carbohydrate 8.9 g/100 mL．The content of micronutrients in the whole shelf life meets the requirements of the general rules．The loss rate of vitamins is generally higher than that of minerals，among which the loss rates of vitamin B2，vitamin C，vitamin E and folic acid are the highest．The results of the crowd drinking test showed that there was no significant difference in blood pressure，heart rate，blood routine， liver and kidney function and electrocardiogram between the subjects after continuous drinking for two months and before drinking，indicating that the product was safe．

Key words: total nutrition, liquid formula food for special medical purposes, formulation design, stability study, drinking test