To determine the effects of astragalus polysaccharide(APS) combined with Yinhuang soluble powder on immunity and diseases of neonatal calves, 80 neonatal Holstein calves in good health were divided into 2 groups randomly(N=40). The calves in the experimental group were fed with 5 g APS powder and 3 g Yinhuang soluble powder for 7 consecutive days, while the control group was not given any medication. The immune-related indicators were measured at the 7th day and the incidence was observed within 3 weeks. Compared with control group, serum IL-2 concentration of calves in experimental groups increased 8.0% and TNF-α concentration decreased 16.0%. The distribution of T cell lymphocyte subsets improved, and the CD4/CD8 value increased 6.0%. Serum total protein and IgG increased 0.28 g/dL and 0.24 mg/ mL respectively. Incidence rate of calf diarrhea was significantly reduced 15.0% (P < 0.05) in low-risk farm within 7 days and 35.0% (P < 0.05) in high-risk farm within 8~21 d. For respiratory diseases,incidence and disease index were significantly reduced 30.0% (P < 0.05) in high-risk farm. APS combined with Yinhuang soluble powder can effectively improve the immunity of neonatal calves and reduce the incidence of respiratory diseases and diarrhea.
GUO Sifan, CAO Jie
. Effects of Astragalus Polysaccharide Combined with Yinhuang Soluble Powder on Immunity and Diseases in Neonatal Calves[J]. China Dairy, 2021
, 0(10)
: 61
-66
.
DOI: 10.12377/1671-4393.21.10.13
[1] Osorio J S.Gut health,stress,and immunity in neonatal dairy calves; the host side of host-pathogen interactions[J]. Journal of Animal Science and Biotechnology,2020,11(1):49-63.
[2] Dong N,Li X,Xue C,et al.Astragalus polysaccharides alleviates LPS‐induced inflammation via the NF-κB/MAPK signaling pathway[J]. Journal of Cellular Physiology,2020,235(7-8):5525-5540.
[3] Zheng Y,Ren W,Zhang L,et al.A review of the pharmacological action of astragalus polysaccharide[J]. Frontiers in Pharmacology,2020,11:349
[4] Chen C Y,Qi L W,Li H J,et al.Simultaneous determination of iridoids,phenolic acids,flavonoids,and saponins in Flos Lonicerae and Flos Lonicerae Japonicae by HPLC‐DAD‐ELSD coupled with principal component analysis[J]. Journal of Separation Science,2007,30(18):3181-3192.
[5] 孙珍洁,陆春雪. CD8+T细胞抗衣原体感染研究进展[J]. 微生物学免疫学进展,2018,46(6):80-84.
[6] Svensson C,Liberg P.The effect of group size on health and growth rate of Swedish dairy calves housed in pens with automatic milk-feeders[J]. Preventive Veterinary Medicine,2006,73(1):43-53.
[7] Costa J H C,Keyserlingk M A G V,Weary D M. Invited review;Effects of group housing of dairy calves on behavior, cognition, performance,and health[J]. Journal of Dairy Science,2016,99(4):2453-2467.
[8] Liu Q Y,Yao Y M,Zhang S W,et al.Astragalus polysaccharides regulate T cell-mediated immunity via CD11c(high)CD45RB(low)DCs in vitro[J]. Journal of Ethnopharmacology,2011,136(3):457-464.
[9] Xu S W,Wusiman A,Liu Z G,et al.pH-responsive Astragalus polysaccharides-loaded poly(lactic- co -glycolic acid) nanoparticles and their in vitro immunogenicity[J]. International Journal of Biological Macromolecules,2019, 125:865-875.
