In the context of COVID-19,consumers pay more attention to nutrition and health for dairy products. Dairy products with better quality and high protein nutrition have become a new category in the market. RO membrane filtration system concentrates milk at low temperature by pressure drive,which maximizes the nutritional composition and taste of milk. Its equipment is simple in configuration and convenient in operation. It has been vigorously promoted in dairy industry in recent two years,becoming another new milk concentration process after flash evaporation process. In this paper,RO membrane filtration system was studied in the key control points of dairy production process,membrane pollution and control measures,CIP cleaning and disinfection,so as to provide reference for RO membrane application in dairy factory.