Abstract: [Objective] The purpose of this study is to systematically analyze the key pathogenic factors of cow hoof disease,build a multi-dimensional comprehensive prevention and control system,and provide theoretical basis for reducing the incidence of hoof disease and improving the health level of cows.[Method] Through literature analysis and field investigation,the pathogenic mechanisms such as genetic susceptibility,nutritional imbalance,humid environment and microbial infection were clarified,and the “genetic-nutritional-environmental”trinity prevention and control strategy covering genetic improvement,precise nutrition regulation,environmental management and hoof bath health care was designed.[Result] The implementation of this system can effectively reduce the incidence of hoof disease,improve the cure rate of hoof infection and reduce the elimination rate of cows.[Conclusion] Multi-factor synergistic prevention and control can effectively block the occurrence path of hoof disease,which has significant economic benefits and popularization value.

Key words: cow, hoof disease, etiology, treatment and disposal, prevention