Abstract: To elucidate the pathogenesis of hypocalcemia in perinatal dairy cows, optimize the comprehensive prevention and treatment strategies for the disease, and mitigate its adverse effects on cow health and farm production efficiency, this study systematically reviewed the application principles and practical key points of prevention and treatment methods including modern nutritional regulation, calcium therapy, and traditional Chinese veterinary medicine based on syndrome differentiation, starting from the analysis of etiology and physiological mechanisms;establishing a comprehensive prevention and control system centered on precision nutrition for prevention, rapid calcium therapy for emergencies, and integrated traditional Chinese and Western medicine for supportive care could significantly reduce the incidence of clinical and subclinical hypocalcemia and minimize the risk of secondary perinatal metabolic diseases. This comprehensive prevention and treatment strategy can effectively ensure the physiological health of perinatal cows and improve their lactation and reproductive performance. Among them, the prevention and control concept of integrated traditional Chinese and Western medicine provides an efficient and sustainable practical pathway for large-scale farms to address the challenge of hypocalcemia.

Key words: dairy cows, perinatal period, hypocalcemia, nutritional regulation, integrated traditional Chinese and Western medicine, prevention and treatment strategies