益生菌在功能性乳制品中功效与作用机制研究进展

doi:10.12377/1671-4393.25.05.15

Abstract

Abstract: Probiotics,mainly lactic acid bacteria（LAB）,play a key role in the research and development of functional dairy products.They can regulate the intestines and improve intestinal related diseases.Their potential functions include competing for adhesion sites,producing bactericides,improving intestinal permeability,releasing active metabolites,regulating immunity and stimulating cellular protective responses,etc.This review mainly introduced the efficacy and mechanism of action of probiotics in functional dairy products,and analyzed the possible difficulties and challenges in their application,providing a reference for the development and application of functional dairy products.

Key words: functional dairy product, probiotic, intestinal health, immune regulation, gut-brain axis

ZHANG Bing, FU Qiang, TANG Shiyun, MENG Weiqin, FU Shijun. Research Progress on the Efficacy and Mechanism of Action of Probiotics in Functional Dairy Products[J].China Dairy, 2025, 0(5): 93-99.

References

[1] 沈郁,高雷,苏丹婷,等. 含有LG21乳酸菌酸奶对功能性消化不良人群症状改善的效果评价[J].健康研究,2023,43(2):130-134.
[2] 孙二娜,张小妹,赵伊凡,等. 副干酪乳杆菌LC-37乳酸菌饮料对人体的促消化和调节肠道菌群作用[J]. 中国食品学报,2021,21(10):95-100.
[3] Shen X,xie A,Li Z,et al. Research Progress for Probiotics Regulating Intestinal Flora to Improve Functional Dyspepsia: A Review[J]. Foods (Basel, Switzerland),2024,13(1):151.
[4] Lin M Y,Savaiano D,Harlander S.Influence of nonfermented dairy products containing bacterial starter cultures on lactose maldigestion in humans[J]. Journal of Dairy Science,1991,74(1):87-95.
[5] Cano-contreras A D,Minero Alfaro I J,Medina López V M,et al. Efficacy of i3.1 Probiotic on Improvement of Lactose Intolerance Symptoms: A Randomized, Placebo-controlled Clinical Trial[J]. Journal of Clinical Gastroenterology,2022,56(2):141-147.
[6] Ahn S I,Kim M S,Park D G,et al.Effects of probiotics administration on lactose intolerance in adulthood: A meta-analysis[J]. Journal of Dairy Science,2023,106(7):4489-4501.
[7] Liu X,Zhang Y,Chu J,et al.Effect of probiotics on the nutritional status of severe stroke patients with nasal feeding that receive enteral nutrition: A protocol for systematic review and meta-analysis of randomized controlled trials[J]. Medicine,2021,100(17):e25657.
[8] Skrzydło-Radomańska B,Prozorow-Król B,Cichoż-Lach H,et al.The Effectiveness of Synbiotic Preparation Containing Lactobacillus and Bifidobacterium Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant Irritable Bowel Syndrome-A Randomized Double-Blind, Placebo-Controlled Study[J]. Nutrients,2020,12(7):1999.
[9] Alsuwaylihi A S,Mccullough F.The safety and efficacy of probiotic supplementation for critically ill adult patients: a systematic review and meta-analysis[J]. Nutrition Reviews,2023,81(3):322-332.
[10] Lee Z Y,Lew C C H,Ortiz-Reyes A,et al. Benefits and harm of probiotics and synbiotics in adult critically ill patients. A systematic review and meta-analysis of randomized controlled trials with trial sequential analysis[J]. Clinical Nutrition (Edinburgh, Scotland),2023,42(4):519-531.
[11] He Y J,You C G.The Potential Role of Gut Microbiota in the Prevention and Treatment of Lipid Metabolism Disorders[J]. International Journal of Endocrinology,2020,(1):8601796.
[12] Rastelli M,Knauf C,Cani P D.Gut Microbes and Health: A Focus on the Mechanisms Linking Microbes, Obesity, and Related Disorders[J]. Obesity (Silver Spring, Md.),2018,26(5):792-800.
[13] Caricilli A M,Saad M J A. Gut microbiota composition and its effects on obesity and insulin resistance[J]. Current Opinion in Clinical Nutrition and Metabolic Care,2014,17(4):312-318.
[14] Fan Y,Pedersen O.Gut microbiota in human metabolic health and disease[J]. Nature Reviews. Microbiology,2021,19(1):55-71.
[15] Barros C P,Grom L C,Guimarães J T,et al.Paraprobiotic obtained by ohmic heating added in whey-grape juice drink is effective to control postprandial glycemia in healthy adults[J]. Food Research International,2021,140:109905.
[16] Yao Y, Hong Q, Ding S,et al.Meta-analysis of the effects of probiotics on hyperlipidemia[J]. Current Research in Food Science,2024,9:100885.
[17] Bock P M,Telo G H,Ramalho R,et al.The effect of probiotics, prebiotics or synbiotics on metabolic outcomes in individuals with diabetes: a systematic review and meta-analysis[J]. Diabetologia,2021,64(1):26-41.
[18] Zhang S,Zhao J,Xie F,et al.Dietary fiber-derived short-chain fatty acids: A potential therapeutic target to alleviate obesity-related nonalcoholic fatty liver disease[J]. Obesity Reviews: An Official Journal of the International Association for the Study of Obesity,2021,22(11):e13316.
[19] Xu L,Yang Q,Zhou J.Mechanisms of Abnormal Lipid Metabolism in the Pathogenesis of Disease[J]. International Journal of Molecular Sciences,2024,25(15):8465.
[20] Zhao M,Kuang W,Yang J,et al.Cholesterol lowering in diet-induced hypercholesterolemic mice using Lactobacillus bile salt hydrolases with different substrate specificities[J]. Food & Function,2024,15(3):1340-1354.
[21] Tang C,Meng F,Pang X,et al.Protective effects of Lactobacillus acidophilus NX2-6 against oleic acid-induced steatosis, mitochondrial dysfunction, endoplasmic reticulum stress and inflammatory responses[J]. Journal of Functional Foods,2020,74:104206.
[22] Nicolucci A C, Hume M P, Martínez I,et al.Prebiotics Reduce Body Fat and Alter Intestinal Microbiota in Children Who Are Overweight or With Obesity[J]. Gastroenterology,2017,153(3):711-722.
[23] Zhang L,Wang F,Wang R,et al.Effects of probiotics, prebiotics, and synbiotics on cardiometabolic risk factors in children and adolescents with overweight or obesity: a systematic review and Bayesian network meta-analysis[J]. Critical Reviews in Food Science and Nutrition,2024:1-15.
[24] Shen Y L,Zhang L Q,Yang Y,et al.Advances in the role and mechanism of lactic acid bacteria in treating obesity[J]. Food Bioengineering,2022,1(1):101-115.
[25] Yue C,Tang Y,Chang M,et al.Dietary supplementation with short- and long-chain structured lipids alleviates obesity via regulating hepatic lipid metabolism, inflammation and gut microbiota in high-fat-diet-induced obese mice[J]. Journal of the Science of Food and Agriculture,2024,104(9):5089-5103.
[26] Chen M Y,Meng X F,Han Y P,et al.Profile of crosstalk between glucose and lipid metabolic disturbance and diabetic cardiomyopathy: Inflammation and oxidative stress[J]. Frontiers in Endocrinology,2022,13:983713.
[27] Thomopoulos C,Bazoukis G,Grassi G,et al.Monotherapy vs combination treatments of different complexity: a meta-analysis of blood pressure lowering randomized outcome trials[J]. Journal of Hypertension,2021,39(5):846-855.
[28] Yu J, Sun M, Jiang S,et al.Oral Administration of Fermented Milk from Co-Starter Containing Lactobacillus plantarum Y44 Shows an Ameliorating Effect on Hypertension in Spontaneously Hypertensive Rats[J]. Foods (Basel, Switzerland),2024,13(5):641.
[29] R Muralitharan R,Marques F Z. Diet-related gut microbial metabolites and sensing in hypertension[J]. Journal of Human Hypertension,2021,35(2):162-169.
[30] Lin J H, Lin C H, Kuo Y W,et al.Probiotic Lactobacillus fermentum TSF331, Lactobacillus reuteri TSR332, and Lactobacillus plantarum TSP05 improved liver function and uric acid management-A pilot study[J]. PLOS ONE, 2024, 19(7): e0307181.
[31] Kuo Y W, Hsieh S H, Chen J F,et al.Lactobacillus reuteri TSR332 and Lactobacillus fermentum TSF331 stabilize serum uric acid levels and prevent hyperuricemia in rats[J]. PeerJ,2021,9:e11209.
[32] Zhao X,Peng F,Liu Z,et al.Lactic acid bacteria with anti-hyperuricemia ability: Screening in vitro and evaluating in mice[J]. Food Bioscience,2023,52:102411.
[33] Wang H, Mei L, Deng Y,et al.Lactobacillus brevis DM9218 ameliorates fructose-induced hyperuricemia through inosine degradation and manipulation of intestinal dysbiosis[J]. Nutrition,2019,62:63-73.
[34] 于鑫迪,刘静雅,任秀梅,等. 功能性牦牛酸奶制备、贮藏期内品质及降嘌呤活性研究[J]. 食品工业科技,2024,45(21):20-29.
[35] 乐卿清,杨隆河,蔡兵,等. 复合益生菌配方对高尿酸、高血脂和高血糖小鼠的调节作用[J]. 中国食品工业,2022(20):100-103.
[36] Kim D,Moon J S,Kim J E,et al.Evaluation of purine-nucleoside degrading ability and in vivo uric acid lowering of Streptococcus thermophilus IDCC 2201, a novel antiuricemia strain[J]. PloS One,2024,19(2):e0293378.
[37] Shao X,Sun S,Zhou Y,et al.Bacteroides fragilis restricts colitis-associated cancer via negative regulation of the NLRP3 axis[J]. Cancer Letters,2021,523:170-181.
[38] Ha S,Zhang X,Yu J.Probiotics intervention in colorectal cancer: From traditional approaches to novel strategies[J]. Chinese Medical Journal, 2024, 137(1): 8-20.
[39] Saffar K N,Larypoor M,Torbati M B.Analyzing of colorectal cancerrelated genes and microRNAs expression profiles in response to probiotics Lactobacillus acidophilus and Saccharomyces cerevisiae in colon cancer cell lines[J]. Molecular Biology Reports,2024,51(1):122.
[40] Li Y,Li Q,Yuan R,et al.Bifidobacterium breve-derived indole-3-lactic acid ameliorates colitis-associated tumorigenesis by directing the differentiation of immature colonic macrophages[J]. Theranostics,2024,14(7):2719-2735.
[41] Li X,Yan Y,Du X,et al.Yogurt Prevents Colitis-Associated Colorectal Cancer in Mice[J]. Molecular Nutrition & Food Research, 2023, 67(24): e2300444.
[42] Su A C Y, Ding X, Lau H C H,et al. Lactococcus lactis HkyuLL 10 suppresses colorectal tumourigenesis and restores gut microbiota through its generated alpha-mannosidase[J]. Gut,2024,73(9):1478-1488.
[43] Chen Y Y,Fei F,Ding L L,et al.Integrated gut microbiome and metabolome analysis reveals the inhibition effect of Lactobacillus plantarum CBT against colorectal cancer[J]. Food & Function,2024,15(2):853-865.
[44] Kim C S,Jung M H,Choi E Y,et al.Probiotic supplementation has sex-dependent effects on immune responses in association with the gut microbiota in community-dwelling older adults: a randomized, double-blind, placebo-controlled, multicenter trial[J]. Nutrition Research and Practice,2023,17(5):883-898.
[45] Yadav M K,Kumari I,Singh B,et al.Probiotics, prebiotics and synbiotics: Safe options for next-generation therapeutics[J]. Applied Microbiology and Biotechnology,2022,106(2):505-521.
[46] Malagón-Rojas J N,MantziarI A,Salminen S,et al. Postbiotics for Preventing and Treating Common Infectious Diseases in Children: A Systematic Review[J]. Nutrients,2020,12(2):389.
[47] Qu S,Zheng Y,Huang Y,et al.Excessive consumption of mucin by over-colonized Akkermansia muciniphila promotes intestinal barrier damage during malignant intestinal environment[J]. Frontiers in Microbiology,2023,14:1111911.
[48] Sarkar S. pROBIOTIC icecream as a functional food - a review[J]. Nutrition & Food Science,2024,54(5):865-889.
[49] Razavi S,Janfaza S,Tasnim N,et al.Nanomaterial-based encapsulation for controlled gastrointestinal delivery of viable probiotic bacteria[J]. Nanoscale Advances,2021,3(10):2699-2709.
[50] Xu C,Ban Q,Wang W,et al.Novel nano-encapsulated probiotic agents: Encapsulate materials, delivery, and encapsulation systems[J]. Journal of Controlled Release: Official Journal of the Controlled Release Society,2022,349:184-205.
[51] 李凯锋,胡姝敏,宫春颖,等.牛初乳益生菌粉调节免疫和肠道菌群保健功能的研究[J].中国乳业,2024(9):73-79.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

Comments

Recommended 0

No Suggested Reading articles found!

Research Progress on the Efficacy and Mechanism of Action of Probiotics in Functional Dairy Products

PDF (PC)

Abstract

Cite this article

share this article

References

Related Articles 13

Metrics

Comments

Recommended 0

[1]	LIU Dunzhang, HU Dingdang. Effects of Probiotic Fermented Feed on Intestinal Flora and Performance of Dairy Cows with Eugastritis [J]. China Dairy, 2025, 0(3): 57-60.
[2]	LI Kaifeng, HU Shumin, GONG Chunying, WANG Shuai, WANG Qingyun. Study on the Health Functions of Immune-regulating and Gut Microbiota of Bovine Colostrum Probiotic Powder [J]. China Dairy, 2024, 0(9): 73-79.
[3]	WANG Guojiao, HONG Qing, LIU Zhenmin, WANG Jidong, YONG Jingyi. Recent Advances on the Effect of Probiotic Fermented Milk on Body Health [J]. China Dairy, 2024, 0(7): 106-110.
[4]	BI Jinfeng. Analysis of the Therapeutic Effect of Probiotics on Rumen Acidosis of Cows [J]. China Dairy, 2024, 0(7): 69-72.
[5]	CHEN Chunlei. Effects of Probiotic Fermented Feed on Intestinal Flora and Production Performance of Dairy Cows [J]. China Dairy, 2024, 0(5): 53-57.
[6]	CAI Yunge. Research Progress of Probiotics in Treating Cow Mastitis [J]. China Dairy, 2023, 0(4): 67-71.
[7]	GONG Lishu, ZHANG Mingfeng. Research Progress on Nutritional Value and Health Benefits of Dairy Products [J]. China Dairy, 2023, 0(11): 13-17.
[8]	YIN Jia, FENG Like, YANG Aijun, PENG Xiaoxia, LI Li. Research Progress of B Vitamins-producing Microorganisms [J]. China Dairy, 2023, 0(10): 105-115.
[9]	GAO Yan, YANG Shengchun, ZENG Jun, HUO Xiangdong, SUN Jian, LIN Qing. Effects of Probiotics on Growth Performance and Serum Indexes of Weaned Calves [J]. China Dairy, 2022, 0(8): 19-23.
[10]	YANG Lu. Effect of Probiotics on Milk Yield,Milk Composition and Rumenmicrobiota of Dairy Cows [J]. China Dairy, 2022, 0(8): 15-18.
[11]	SUOLANG Quji, ZHAO Li, DANZENG Luosang, CIREN Luobu, CIREN Lamu, GESANG Zhuoga, BIANDAN Yixi, BASANG Zhuzha. Study on the Effect of Compound Feed Additive on the Quality of Juanshan Milk [J]. China Dairy, 2022, 0(6): 35-38.
[12]	YANG Pengfei, WU Tong, XIE Kui, DENG Youtian, JIANG Feirong, LU Suyun, HOU Yanmei. Study on the Effect of Goat Milk Formula on the Immune Function on Mice [J]. China Dairy, 2021, 0(12): 133-136.
[13]	SUI Chunli, LENG Shangji, LIU Xiangming. Application of Microecological Preparations in Dairy Cattle Breeding [J]. China Dairy, 2021, 0(12): 67-69.