China Dairy ›› 2023, Vol. 0 ›› Issue (2): 15-19.doi: 10.12377/1671-4393.23.02.03

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Melatonin Rhythm and Function in Milk

LIU Yunjie1, CHANG Yi2, LIAO Chenxing2, LIU Qiaoxiang2, GUO Gang2, GAO Jiarui3, LI Youzhi4, MA Hui2,*, LIU Guoshi1,*   

  1. 1College of Animal Science and Technology,China Agricultural University,Beijing 100193;
    2Beijing Capital Agribusiness & Foods Group,Beijing 100028;
    3College of Animal Science and Technology,Beijing University of Agriculture,Beijing 102206;
    4Shandong Feed and Veterinary Drug Quality Inspection Center,Jinan Shandong 250109
  • Online:2023-02-25 Published:2023-03-10

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Abstract: Milk is known as the white blood. In addition to nutrients,milk also contains a range of non-nutrient components. As a multifunctional small molecule,the most prominent properties of melatonin are its regulation of circadian rhythms and its anti-inflammatory and antioxidant effects. Melatonin in mammalian milk affects the function and immune activity of milk. This paperreviewed the rhythmic changes of melatonin in mammalian milk and its sources and functions, aiming to provide a reference for further research and exploitation of melatonin functions in milk.

Key words: melatonin, milk, blood, circadian rhythm

[1] Amaral F,Cipolla-Neto J.A brief review about melatonin,a pineal hormone[J]. Arch Endocrinol Metab,2018,62(4):472-479.
[2] Tan D,Reiter R J.Mitochondria:the birth place,battle ground and the site of melatonin metabolism in cells[J]. Melatonin Research,2019,2(1):44-66.
[3] Tajes M,Gutierrez-Cuesta J,Ortuno-Sahagun D,et al.Anti-aging properties of melatonin in an in vitro murine senescence model:involvement of the sirtuin 1 pathway[J]. Journal of Pineal Research,2009,47(3):228-237.
[4] Li Y,Li S,Zhou Y,et al.Melatonin for the prevention and treatment of cancer[J]. Oncotarget. 2017,8(24):39896.
[5] Asher A,Shabtay A,Brosh A,et al.Chrono-functional milk:the difference between melatonin concentrations in night-milk versus day-milk under different night illumination conditions[J]. Chronobiology International,2015,32(10):1409-1416.
[6] Milagres M P,Minim V P,Minim L A,et al.Night milking adds value to cow's milk[J]. Journal of Science and Food Agriculture,2014,94(8):1688-1692.
[7] Kumar J P,Challet E,Kalsbeek A. Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals[J]. Mol Cell Endocrinol.2015,418 Pt 1:74-88.
[8] Davies S K,Ang J E Revell V L,et al. Effect of sleep deprivation on the human metabolome[J]. Proceedings of the National Academy of Sciences of the United States of America,2014,111(29):10761-10766.
[9] Lerner A B,Case J D,Takahashi Y,et al.Isolation of melatonin, the pineal gland factor that lightens melanocytes1[J]. Journal of the American Chemical Society,1958,80(10):2587.
[10] Ellison N,Weller J L,Klein D C.Development of a circadian rhythm in the activity of pineal serotonin N-acetyltransferase[J]. Journal of Neurochemisty,1972,19(5): 1335-1341.
[11] Pfeffer M,Stehle J H.Ontogeny of a diurnal rhythm in arylalkylamine-N-acetyltransferase mRNA in rat pineal gland[J]. Neuroscience Letters,1998,248(3):163-166.
[12] Klein D C,Weller J L.Indole metabolism in the pineal gland: a circadian rhythm in N-acetyltransferase[J]. Science,1970,169(3950):1093-1095.
[13] Klein D C,Moore R Y.Pineal N-acetyltransferase and hydroxyindole-O-methyltransferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus[J]. Brain Researh,1979, 174(2): 245-262.
[14] Macchi M M,Bruce J N.Human pineal physiology and functional significance of melatonin[J]. Front Neuroendocrinol,2004,25(3-4):177-195.
[15] 杨明辉,史建民,陶景丽,等.外源褪黑素处理方式对荷斯坦奶牛体内褪黑素富集与代谢的影响[J].中国畜牧兽医,2017,44(9):2613-2262.
[16] Illnerová H,Buresová M,Presl J.Melatonin rhythm in human milk[J]. Journal of Clinical Endocrinology and Metabolism,1993,77(3):838.
[17] Romanini E B,Volpato A M,Dos Santos J S,et al. Melatonin concentration in cow's milk and sources of its variation[J]. Journal of Applied Animal Research,2019,47(1):140-145.
[18] Castro N,Spengler M,Lollivier V,et al.Diurnal pattern of melatonin in blood and milk of dairy cows[J]. Milchwissenschaft,2011,66(4):352-353.
[19] Silva N A,Honorio-Franca A C,Giachini F R,et al. Bioactive factors of colostrum and human milk exhibits a day-night variation[J]. American Journal of Reproductive Immunology,2013,9(2): 68-74.
[20] Qin Y,Shi W,Zhuang J,et al.Variations in melatonin levels in preterm and term human breast milk during the first month after delivery[J]. Scientific Report,2019,9(1):17984.
[21] Biran V,Decobert F,Bednarek N,et al.Melatonin levels in preterm and term infants and their mothers[J]. International Journal of Molecular Sciences,2019,20(9):2077.
[22] Rowe S A,Kennaway D J.Melatonin in rat milk and the likelihood of its role in postnatal maternal entrainment of rhythms[J]. American Journal of Physiology Regulatory Integrative and Comparative Physiology,2002,282(3):R797-R804.
[23] Romanini E B,Volpato A M,Sifuentes Dos Santos J,et al. Melatonin concentration in cow's milk and sources of its variation[J]. Journal of Applied Animal Research,2019,47(1):140-145.
[24] Eriksson L,Valtonen M,Laitinen J T,et al.Diurnal rhythm of melatonin in bovine milk: pharmacokinetics of exogenous melatonin in lactating cows and goats[J]. Acta Veterinaria Scandinavica,1998,39(3):301-310.
[25] Kollmann M T,Locher M,Hirche F,et al.Effects of tryptophan supplementation on plasma tryptophan and related hormone levels in heifers and dairy cows[J]. Domest Animial Endocrinol,2008,34(1):14-24.
[26] Eriksson L,Valtonen M,Laitinen J T,et al.Diurnal rhythm of melatonin in bovine milk: Pharmacokinetics of exogenous melatonin in lactating cows and goats[J]. Acta Veterinaria Scandinavica,1998,39(3):301-310.
[27] Reppert S M Klein D C. Transport of maternal[3H]melatonin to suckling rats and the fate of [3H]melatonin in the neonatal rat[J]. Endocrinology (Philadelphia),1978,102(2):582.
[28] Pontes G N,Cardoso E C,Carneiro-Sampaio M M,et al. Injury switches melatonin production source from endocrine (pineal) to paracrine (phagocytes)-melatonin in human colostrum and colostrum phagocytes[J]. Journal of Pineal Research,2006,41(2):136-141.
[29] Caba-Flores M D,Ramos-Ligonio A,Camacho-Morales A,et al. Breast milk and the importance of chrononutrition[J]. Frontiers in Nutrition,2022,9:867507.
[30] Abdul J N,Tham E,Pang W W,et al.Association between breastfeeding and sleep patterns in infants and preschool children[J]. American Journal of Clinical Nutrition,2021,114(6):1986-1996.
[31] Kikuchi S,Nishihara K,Horiuchi S,et al.The influence of feeding method on a mother's circadian rhythm and on the development of her infant's circadian rest-activity rhythm[J]. Early Human Developmeng,2020,145:105046.
[32] Henderson R,Kim S,Lee E.Use of melatonin as adjunctive therapy in neonatal sepsis:a systematic review and meta-analysis[J]. Complementary Therapies in Medicine,2018,39:131-136.
[33] Gitto E,Karbownik M,Reiter R J,et al.Effects of melatonin treatment in septic newborns[J]. Pediatric Research,2001,50(6):756-760.
[34] Gitto E,Pellegrino S,Gitto P,et al.Oxidative stress of the newborn in the pre‐and postnatal period and the clinical utility of melatonin[J]. Journal of Pineal Research,2009,46(2):128-139.
[35] Katzer D,Pauli L,Mueller A,et al.Melatonin concentrations and antioxidative capacity of human breast milk according to gestational age and the time of day[J]. Journal of Human Lactation,2016, 32(4):105-110.
[36] Kanikowska D,Roszak M,Rutkowski R,et al.Seasonal differences in rhythmicity of salivary cortisol in healthy adults[J]. Journal of Applied Physiology,2019,126(3):764-770.
[37] Pontes G N,Cardoso E C,Carneiro-Sampaio M M,et al. Injury switches melatonin production source from endocrine (pineal)to paracrine(phagocytes) - melatonin in human colostrum and colostrum phagocytes[J].Journal of Pineal Research,2006, 41(2):136-141.
[38] Filteau S.The influence of mastitis on antibody transfer to infants through breast milk[J]. Vaccine,2003,21(24):3377-3381.
[39] Honorio-França C A,Pernet Hara C C,Ormonde S J V,et al. Human colostrum melatonin exhibits a day-night variation and modulates the activity of colostral phagocytes[J]. Journal of Applied Biomedicine,2013,11(3):153-162.
[40] Silva S O,Carvalho S R,Ximenes V F,et al.Melatonin and its kynurenin-like oxidation products affect the microbicidal activity of neutrophils[J]. Microbes and Infection,2006,8(2):420-425.
[41] Molad M,Ashkenazi L,Gover A,et al.Melatonin Stability in Human Milk[J]. Breastfeeding Medicine,2019,14(9):680-682.
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