奶牛代谢紊乱与褪黑素应用研究进展

摘要/Abstract

摘要： 高产奶牛妊娠或分娩后,泌乳启动产奶量增加使机体营养物质需求量增加,同时饲料营养水平供应不足,使机体发生负能量平衡（NEB）,逐渐由能量代谢紊乱发展为酮病、糖尿病和脂肪肝等代谢疾病。患病机体平衡能量,增加脂肪、蛋白质和肌肉的代谢,增大机体的负担,损伤代谢器官,干扰内分泌网络,导致奶牛体重降低,产奶量下降,炎症反应增加,免疫能力下降,奶牛不孕,繁殖率降低,严重时还会引发其他疾病。群发性代谢疾病影响奶牛产量,造成奶牛养殖的巨大损失。因此研究奶牛代谢紊乱的发病原因,缓解代谢疾病早期症状,并找到更好的预防和治疗方案是当下研究重点。近年来褪黑素在生产上的应用越来越广泛,随着对褪黑素参与代谢调节,改善代谢紊乱作用机制的研究,褪黑素或许可以作为预防和治疗奶牛代谢紊乱的新途径。本文综述了代谢紊乱引起奶牛酮病和脂肪肝的发病原因,代谢疾病对奶牛生殖功能造成损伤以及褪黑素改善代谢紊乱的作用机理,并对褪黑素在缓解奶牛生产难题的优势作用进行展望。

关键词: 褪黑素, 代谢紊乱, 酮病, 脂肪肝, 繁殖障碍

姚昱君, 郭江鹏, 张鲁, 路永强, 刘国世. 奶牛代谢紊乱与褪黑素应用研究进展[J]. 中国乳业, 2019, 0(4): 71-75.

参考文献

[1] Rutherford A J,Oikonomou G,Smith R F.The effect of subclinical ketosis on activity at estrus and reproductive performance in dairy cattle[J].Journal of Dairy Science.2016,99(6):4808-4815.
[2] 韩建滨.奶牛酮病与分娩前后能量代谢、生产性能和繁殖性能的关系研究:[硕士论文][D].南宁:广西大学,2012.
[3] Contreras G A,Sordillo L M.Lipid mobilization and inflammatory responses during the transition period of dairy cows[J].Comparative Immunology Microbiology Infectious Diseases,2011,34(3):281-289.
[4] Wathes D C,Fenwick M,Cheng Z,et al.Influence of negative energy balance on cyclicity and fertility in the high producing dairy cow[J].Theriogenology,2007,68(Suppl 1):S232-S241.
[5] 李成海.围产期奶牛的能量负平衡及能量代谢障碍性疾病研究[J].畜牧兽医科技信息,2015(7):69-70.
[6] 张红茹.围产期奶牛的脂肪肝综合征和酮病的防治措施[J].畜牧兽医科技信息,2018(7):68.
[7] Leroy J L,Soom A V,Opsomer G,et al.The consequences of metabolic changes in high-yielding dairy cows on oocyte and embryo quality[J].Animal An International Journal of Animal Bioscience,2008,2(8):1120-1127.
[8] González F D,Muiño R,Pereira V,et al.Relationship among blood indicators of lipomobilization and hepatic function during early lactation in high-yielding dairy cows[J].Journal of Veterinary Science,2011,12(3):251.
[9] Ohtsu A,Tanaka H,Seno K,et al.Palmitic acid stimulates interleukin-8 via the TLR4/NF-κB/ROS pathway and induces mitochondrial dysfunction in bovine oviduct epithelial cells[J].American Journal of Reproductive Immunology,2017,77(6):e12642.
[10] 张敏.能量负平衡奶牛肝脂沉积过程中SREBP-1c/Cidea通路的作用机制:[硕士论文][D].长春:吉林大学,2016.
[11] Kawashima C,N I,S N,et al.Influence of hepatic load from far-off dry period to early postpartum period on the first postpartum ovulation and accompanying subsequent fertility in dairy cows[J].Journal of Reproduction and Development,2016,62(3):289-295.
[12] Leroy J,Vanholder T,Opsomer G,et al.The In Vitro Development of Bovine Oocytes after Maturation in Glucose andβ-Hydroxybutyrate Concentrations Associated with Negative Energy Balance in Dairy Cows[J].Reproduction in Domestic Animals.2006,41(2):119-123.
[13] Iwata H,Tanaka H,Kanke T,et al.Follicle growth and oocyte developmental competence in cows with liver damage[J].Reproduction in Domestic Animals.2010,45(5):888-895.
[14] 周子超,祖卓鑫,滑国华,等.能量负平衡对奶牛繁殖的影响及相关机理[J].动物营养学报,不详:1-7.
[15] 朱奎玲,沈泰钰,于洪江,等.酮病对奶牛生产性能和繁殖性能的影响[J].黑龙江畜牧兽医.2017(4):107-109.
[16] Tanaka H,Shibano K,Monji Y,et al.Liver condition affects bovine oocyte qualities by changing the characteristics of follicular fluid and plasma[J].Reproduction in Domestic Animals,2013,48(4):619-626.
[17] Jordaens L,Van Hoeck V,Maillo V,et al.Maternal metabolic stress may affect oviduct gatekeeper function[J].Reproduction,2017,153(6):759-773.
[18] Spears J W,Weiss W P.Role of antioxidants and trace elements in health and immunity of transition dairy cows.[J].Veterinary Journal,2008,176(1):70-76.
[19] Lacetera N,Scalia D,Franci O,et al.Short communication:effects of nonesterified fatty acids on lymphocyte function in dairy heifers[J].Journal of Dairy Science.2004,87(4):1012-1014.
[20] Navit G,Sharon E,Ilan R,et al.β-hydroxybutyrate abrogates formation of bovine neutrophil extracellular traps and bactericidal activity against mammary pathogenic Escherichia coli[J].Infection &Immunity,2008,76(6):2802-2807.
[21] Sun H,Huang F F,Qu S.Melatonin:a potential intervention for hepatic steatosis[J].Lipids in Health and Disease,2015,14(1):1-6.
[22] Martin S,Lubos M,Hana U,et al.The presence and localization of melatonin receptors in the rat aorta[J].Cellular &Molecular Neurobiology,2011,31(8):1257-1265.
[23] Slominski R M,Reiter R J,Schlabritzloutsevitch N,et al.Melatonin membrane receptors in peripheral tissues:distribution and functions[J].Molecular &Cellular Endocrinology,2012,351(2):152-166.
[24] Reiter R J,Rosales-Corral S A,Manchester L C,et al.Peripheral reproductive organ health and melatonin:ready for prime time[J].International Journal of Molecular Sciences,2013,14(4):7231-7272.
[25] Reynolds C K,Aikman P C,Lupoli B,et al.Splanchnic metabolism of dairy cows during the transition from late gestation through early lactation[J].Journal of Dairy Science,2003,86(4):1201-1217.
[26] Carmen R,Mayo J C,Sainz R M,et al.Regulation of antioxidant enzymes:a significant role for melatonin.[J].Journal of Pineal Research,2010,36(1):1-9.
[27] Steinhilber D,Brungs M,Werz O,et al.The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytes[J].Journal of Biological Chemistry,1995,270(13):7037-7040.
[28] Gitto E,Tan D X,Reiter R J,et al.Individual and synergistic antioxidative actions of melatonin:studies with vitamin E,vitamin C,glutathione and desferrioxamine (desferoxamine)in rat liver homogenates[J].Journal of Pharmacy &Pharmacology,2001,53(10):1393.
[29] Mayo J C,Dun-Xian T,Sainz R M,et al.Oxidative damage to catalase induced by peroxyl radicals:functional protection by melatonin and other antioxidants[J].Free Radical Research Communications,2003,37(5):543-553.
[30] Kornelia K K,Karolina S G,Jolanta C,et al.Effect of melatonin on the oxidative stress in erythrocytes of healthy young and elderly subjects[J].Journal of Pineal Research,2010,42(2):153-158.
[31] Cristina T Z,Ana C M.A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes[J].Journal of Pineal Research.2010,39(2):99-104.
[32] Hussein M R,Ahmed O G,Hassan A F,et al.Intake of melatonin is associated with amelioration of physiological changes,both metabolic and morphological pathologies associated with obesity:an animal model[J].International Journal of Experimental Pathology,2007,88(1):19-29.
[33] 张珍珍,何长久,刘国世.褪黑素对雌性动物繁殖影响的研究进展[J].中国畜牧杂志,2017,53(6):1-3.
[34] Chen X,Zhang C,Zhao M,et al.Melatonin alleviates lipopolysaccharide-induced placental cellular stress response in mice[J].Journal of Pineal Research,2011,51(4):416-425.
[35] Hermoso D A M,Shimada L B C,Gilglioni E H,et al.Melatonin protects female rats against steatosis and liver oxidative stress induced by oestrogen deficiency[J].Life Sciences,2016,157:178-186.
[36] Kim S J,Kang H S,Lee J H,et al.Melatonin ameliorates ER stress-mediated hepatic steatosis through miR-23a in the liver[J].Biochemical &Biophysical Research Communications,2015,458(3):462-469.
[37] Garidou M L,Vivien-Roels B,Pevet P,et al.Mechanisms regulating the marked seasonal variation in melatonin synthesis in the European hamster pineal gland[J].American Journal of Physiology Regulatory Integrative &Comparative Physiology,2003,284(4):R1043.
[38] 卞宏生.昼夜节律对大鼠的睡眠模式和能量代谢的影响及褪黑素的干预作用研究:[博士论文][D].哈尔滨:黑龙江中医药大学,2015.
[39] Russel J R,Dun X T,Ahmet K,et al.Melatonin and stable circadian rhythms optimize maternal,placental and fetal physiology[J].Human Reproduction Update,2014,20(2):293-307.
[40] Carrillo-Vico A,Lardone P J,Alvarez-SãN N,et al.Melatonin:buffering the immune system[J].International Journal of Molecular Sciences,2013,14(4):8638-8683.
[41] R.H.Melatonin and inflammation—Story of a double-edged blad[J].Joumal of Pineal Rearch,2018,65(4):e 12525.
[42] Yang M,Shi J,Tian J,et al.Exogenous melatonin reduces somatic cell count of milk in Holstein cows[J].Scientific Reports,2017,7(1):43280.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed