牛结节性皮肤病是由牛结节性皮肤病病毒引起的一种急性、亚急性或慢性传染病。患病牛的临床症状主要为发热、消瘦、淋巴结肿大、皮肤水肿、局部形成结节或溃疡,影响肉牛增重、奶牛产奶量等,对牛养殖业可造成严重经济损失。疫苗防控动物疫病是一种高效、可控措施,对疫病的预防发挥重要作用。近年国内外研究人员对牛结节性皮肤病疫苗进行研究,取得一定成绩。本文对牛结节性皮肤病疫苗研究进行综述,为后续牛结节性皮肤病疫苗研发提供参考。
Lumpy skin disease is an acute,subacute or chronic infectious disease caused by lumpy skin disease virus.The clinical symptoms of sick cattle mainly include fever,emaciation,swollen lymph nodes,skin edema,local nodules or ulcers,which affect the weight gain of beef cattle and milk yield of dairy cows,and can cause serious economic losses to the cattle breeding industry. Vaccine prevention and control of animal diseases is an efficient and controllable measure,which plays an important role in the prevention of diseases.In recent years,researchers at home and abroad have carried out a series of research on lumpy skin disease vaccine,and achieved certain results.In this paper,the research progress of lumpy skin disease vaccine was reviewed,hoping to provide reference for the follow-up research and development of lumpy skin disease vaccine.
[1] 刘平,李金明,陈荣贵,等.我国首例牛结节性皮肤病的紧急流行病学调查[J].中国动物检疫,2020,37(1):1-5.
[2] 聂福平. 牛结节性皮肤病检测新方法与ORF132基因表达及鉴定研究[D].重庆:重庆大学,2020.
[3] 宋思军. 牛结节性皮肤病的防控[J].中国乳业,2021(8):80-83.
[4] 董云宝. 牛结节性皮肤病的综合防控措施[J].中国乳业, 2022(3):41-45.
[5] Khan Y R,Ali A,Hussain K,et al.A review: Surveillance of lumpy skin disease (LSD)a growing problem in Asia[J].Microbial Pathogenesis,2021,158:105050.
[6] Gari G,Abie G,Gizaw D,et al.Evaluation of the safety,immunogenicity and efficacy of three capripoxvirus vaccine strains against lumpy skin disease virus[J].Vaccine,2015,33(28):3256-3261.
[7] Varshovi H R,Norian R,Azadmehr A,et al.Immune response characteristics of Capri pox virus vaccines following emergency vaccination of cattle against lumpy skin disease virus[J].Iranian Journal of Veterinary Science and Technology,2017,9(2):33-40.
[8] Brenner J,Bellaiche M,Gross E,et al.Appearance of skin lesions in cattle populations vaccinated against lumpy skin disease:Statutory challenge[J].Vaccine, 2009,27(10):1500-1503.
[9] Abutarbush S M,Tuppurainen E S M.Serological and clinical evaluation of the Yugoslavian RM65 sheep pox strain vaccine use in cattle against lumpy skin disease[J]. Transboundary and Emerging Diseases,2018,65(6):1657-1663.
[10] Haegeman A,De Leeuw I,Mostin L,et al.Comparative evaluation of lumpy skin disease virus-based live attenuated vaccines[J].Vaccines (Basel),2021,9(5).
[11] Hamdi J,Boumart Z,Daouam S,et al.Development and evaluation of an inactivated lumpy skin disease vaccine for cattle[J].Veterinary Microbiology,2020,245:108689.
[12] Es-Sadeqy Y,Bamouh Z,Ennahli A,et al.Development of an inactivated combined vaccine for protection of cattle against lumpy skin disease and bluetongue viruses[J].Veterinary Microbiology,2021,256:109046.
[13] Kara P D,Mather A S,Alri P,et al.Characterisation of putative immunomodulatory gene knockouts of lumpy skin disease virus in cattle towards an improved vaccine[J].Vaccine,2018,36(31):4708-4715.
[14] Boshra H,Truong T,Nfon C,et al.A lumpy skin disease virus deficient of an IL-10 gene homologue provides protective immunity against virulent capripoxvirus challenge in sheep and goats[J].Antiviral Research,2015,123:39-49.
