高血压是对人体危害极大的慢性疾病,易引发多种并发症。目前降血压药物大多化学合成,服用后易损伤机体脏器,有较多毒副作用。牛乳营养价值高、富含较多蛋白质,酶解后产生大量生物活性多肽,能提高抗氧化能力。牛乳经酶解后能够产生大量抑制血管紧张素转换酶（ACE）活性的多肽,其无生物毒性,具有舒张血管,降低血压的作用,能够有望用于制备降血压药物。因此,本文对高血压危害、ACE抑制肽作用机制、牛乳中ACE抑制肽研究进行综合概述,有助促进ACE抑制肽商品化和工业化,实现牛乳高价值利用,推动乳业发展。
Hypertension is a chronic disease that is extremely harmful to the human body and can easily lead to a variety of complications. Most of the current blood pressure drugs are chemically synthesized,which are easy to damage the organs of the body and have more toxic side effects after taking them.Milk has high nutritional value, rich in protein, and after enzymatic digestion, it produces a large number of bioactive peptides, which can improve antioxidant capacity. It was found that milk,after enzymatic digestion,can produce a large number of peptides that inhibit angiotensin-converting enzyme （ACE） activity, which are non-biotoxic, have the effect of diastolic blood vessels and lower blood pressure, and can be expected to be used in the preparation of hypotensive drugs. Therefore,this paper provided a comprehensive overview of the hazards of hypertension,the mechanism of action of ACE inhibitory peptide,and the research of ACE inhibitory peptide in milk,which can help promote the commercialization and industrialization of ACE inhibitory peptide,realize the high-value utilization of milk,and promote the development of dairy industry.
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