疾病防治

奶牛乳腺炎金黄色葡萄球菌毒力因子与抗菌素耐药性关系研究进展

  • 伏广达 ,
  • 刘维红 ,
  • 胡智胜
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  • 1 临沂市动物疫病预防控制中心,山东临沂 276000;
    2 山东省畜牧总站,山东济南 250102
伏广达(1981-),男,山东临沂人,本科,高级兽医师,研究方向为畜禽疫病防控、畜禽粪污资源化利用;刘维红(1979-),女,山东临沂人,硕士,高级兽医师,研究方向为畜禽疫病防控、畜禽粪污资源化利用。

网络出版日期: 2025-08-04

基金资助

2023年山东省重点研发计划(农业良种工程品种培育)项目-奶牛关键性状智能选育技术研究与应用(2023LZGC004)

Research Progress on the Relationship Between Staphylococcus aureus Virulence Factors and Antibiotic Resistance in Bovine Mastitis

  • FU Guangda ,
  • LIU Weihong ,
  • HU Zhisheng
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  • 1 Linyi Center for Animal Disease Control and Prevention,Linyi Shandong 276000;
    2 Shandong Provincial Livestock Station,Jinan Shandong 250102

Online published: 2025-08-04

摘要

金黄色葡萄球菌是奶牛乳腺炎的主要致病菌,其毒力因子与抗菌素耐药性对宿主健康和乳制品生产均产生重要影响。毒力因子如生物膜、肠毒素、溶血素等能够促进病原体在乳腺内的定殖和持久感染,而携带的抗菌耐药基因则进一步加剧治疗难度。随着分子生物学和基因组学技术的进步,金黄色葡萄球菌毒力因子与抗菌耐药机制的相互作用逐渐被揭示。本文总结近年来关于金黄色葡萄球菌毒力因子和抗菌耐药基因在奶牛乳腺炎中的研究进展,分析二者之间的协同性及其对感染过程的影响,探讨抗菌药物对病原体毒力与耐药性的调控作用,旨在为奶牛乳腺炎的精准防控及抗菌药物的合理使用提供理论支持。

本文引用格式

伏广达 , 刘维红 , 胡智胜 . 奶牛乳腺炎金黄色葡萄球菌毒力因子与抗菌素耐药性关系研究进展[J]. 中国乳业, 2025 , 0(7) : 90 -99 . DOI: 10.12377/1671-4393.25.07.15

Abstract

Staphylococcus aureus is the main pathogen causing mastitis in dairy cows. Its virulence factors and antibiotic resistance have significant impacts on host health and dairy product production. Virulence factors such as biofilms, enterotoxins, and hemolysins can promote the colonization and persistent infection of pathogens in the breast, while the antibacterial resistance genes carried further increase the difficulty of treatment. With the advancement of molecular biology and genomics techniques, the interaction between virulence factors of Staphylococcus aureus and the mechanism of antibacterial resistance has gradually been revealed. This paper summarizes the research progress in recent years on the virulence factors and antibacterial resistance genes of Staphylococcus aureus in bovine mastitis, analyzes the synergy between the two and their impact on the infection process, and explores the regulatory effect of antibacterial drugs on the virulence and drug resistance of pathogens, aiming to provide theoretical support for the precise prevention and control of bovine mastitis and the rational use of antibacterial drugs.

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