疾病防治

牛结核病检测预警体系的研究进展

  • 陈强斌 ,
  • 房文斌 ,
  • 窦立静 ,
  • 王宏伟 ,
  • 赵艳梅 ,
  • 刘强 ,
  • 叶翠芳
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  • 1 第八师动物疫病预防控制中心,新疆石河子 832000;
    2 石河子大学动物科技学院,新疆石河子 832000
陈强斌(1983-),男,甘肃会宁人,本科,兽医师,研究方向为动物疫病防控与检测;房文斌(1967-),男,陕西临潼人,本科,农业技术推广研究员,研究方向为动物疫病防控检测;窦立静(1975-),女,新疆昌吉人,本科,高级兽医师,研究方向为动物疫病防控与检测;王宏伟(1968-),男,甘肃武威人,本科,高级兽医师,研究方向为动物疫病防控与检测;赵艳梅(1985-),女,山东威海人,本科,兽医师,研究方向为动物疫病防控与检测;刘 强(1970-),男,河北景县人,本科,兽医师,研究方向为动物疫病防控与检测。

网络出版日期: 2025-08-04

基金资助

兵团重点领域科技攻关项目-基于微滴数字PCR技术创建牛结核病检测方法研究与示范(2023AB009-02); 兵团指导性科技计划项目-荷斯坦牛MBL2基因多态性与支原体肺炎相关性研究(2023ZD041)

Research Progress on Early Warning System for Bovine Tuberculosis Detection

  • CHEN Qiangbin ,
  • FANG Wenbin ,
  • DOU Lijing ,
  • WANG Hongwei ,
  • ZHAO Yanmei ,
  • LIU Qiang ,
  • YE Cuifang
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  • 1 The Eighth Division Animal Disease Prevention and Control Center,Shihezi Xinjiang 832000;
    2 College of Animal Science and Technology,Shihezi University,Shihezi Xinjiang 832000

Online published: 2025-08-04

摘要

牛结核病(BovineTuberculosis)主要由结核分枝杆菌复合群(MTBC)引起的慢性消耗性疾病,尤其对奶牛易感性较高,是一种人畜共患病。牛结核病对人类健康和养殖业造成极大威胁和影响,已被很多发达国家列为必须消灭疾病之一。尽管牛结核病诊断和治疗取得重大进展,但仍对全球牛只健康造成严重威胁。早期发现流行病是全世界公共卫生检测的挑战。基于统计数据建立预警体系可以对早期发现牛结核病提供帮助,已成为控制牛结核病传播的重要方法。本文综述牛结核病现状、常见检测方法和预警体系,以期为牛结核病综合防控提供参考。

本文引用格式

陈强斌 , 房文斌 , 窦立静 , 王宏伟 , 赵艳梅 , 刘强 , 叶翠芳 . 牛结核病检测预警体系的研究进展[J]. 中国乳业, 2025 , 0(7) : 99 -104 . DOI: 10.12377/1671-4393.25.07.16

Abstract

Bovine tuberculosis (BT) is a chronic wasting disease primarily caused by the Mycobacterium tuberculosis complex(MTBC),with a particularly high susceptibility among dairy cows. It is a zoonotic disease that poses a significant threat to human health and the livestock industry,and has been designated as a disease to be eradicated by many developed countries. Despite significant progress in the diagnosis and treatment of bovine tuberculosis,it continues to pose a serious threat to global cattle health. Early detection of epidemics remains a major challenge for public health surveillance worldwide. Establishing an early warning system based on statistical data can assist in the early detection of bovine tuberculosis and has become an important method for controlling its spread. This paper reviewed the current status of bovine tuberculosis,common detection methods,and early warning systems,with the aim of providing references for comprehensive prevention and control of the disease.

参考文献

[1] 杨德全,杨显超,沈海潇,等.欧盟、美国及澳大利亚牛结核病防控经验与启示[J].中国动物检疫,2021,38(9):62-65.
[2] Ayalew S,Habtamu G,Melese F,et al.Zoonotic tuberculosis in a high bovine tuberculosis burden area of Ethiopia[J].Frontiers in Public Health,2023,11:1204525.
[3] 吴亚文,王晓亮,张玉玲,等.γ-干扰素ELISA检测方法在牛结核病流行病学调查中的应用[J].中国动物检疫,2016,33(9):78-80.
[4] Morse S S.Public health surveillance and infectious disease detection[J].Biosecurity and Bioterrorism:Biodefense Strategy,Practice,and Science,2012,10(1):6-16.
[5] Qiu Y,Guitian J,Webster J P,et al.Global prioritization of endemic zoonotic diseases for conducting surveillance in domestic animals to protect public health[J].Philosophical Transactions of the Royal Society B,2023,378(1887):20220407.
[6] Wang L,Wang Y,Jin S,et al.Emergence and control of infectious diseases in China[J].The Lancet,2008,372(9649):1598-1605.
[7] 孙雨,马世春,董浩,等.牛结核病的流行病学特征与实验室诊断技术的研究进展[J].畜牧与兽医,2015,47(10):145-148.
[8] Anne N S,Ronald B,Kumar T S,et al.Molecular identification of Mycobacterium tuberculosis in cattle[J].Veterinary Microbiology,2017,198:81-87.
[9] Vordermeier H M,Jones G J,Buddle B M,et al.Bovine tuberculosis in cattle:Vaccines,DIVA tests, and host biomarker discovery[J].Annual Review of Animal Biosciences,2016,4:87-109.
[10] Picasso-Risso C,Grau A,Bakker D,et al.Association between results of diagnostic tests for bovine tuberculosis and Johne’s disease in cattle[J].The Veterinary Record,2019,185(22):693.
[11] Sergeant E,Happold J,Langstaff I.Evaluation of Australian surveillance for freedom from bovine tuberculosis[J].Australian Veterinary Journal,2017,95(12):474-479.
[12] Lucena A N,Cuartero L G,Mulcahy G,et al.The immunoregulatory effects of co-infection with Fasciola hepatica:From bovine tuberculosis to Johne's disease[J].The Veterinary Journal,2017,222:9-16.
[13] Lorente-Leal V,Liandris E,Castellanos E,et al.Validation of a real-time PCR for the detection of Mycobacterium tuberculosis complex members in bovine tissue samples[J].Frontiers in Veterinary Science,2019,6:61.
[14] Asil E T A,El Sanousi S M,Gameel A,et al.Bovine tuberculosis in South Darfur State,Sudan:An abattoir study based on microscopy and molecular detection methods[J].Tropical Animal Health and Production,2013,45:469-472.
[15] Zhao Y,Li G,Sun C,et al.Locked nucleic acid probe-based real-time PCR assay for the rapid detection of rifampin-resistant Mycobacterium tuberculosis[J].PloS One,2015,10(11):e0143444.
[16] Chang H,Huang M,Yeh C,et al.Rapid diagnosis of tuberculosis directly from clinical specimens using a gene chip[J].Clinical Microbiology and Infection,2010,16(8):1090-1096.
[17] Buddle B M,Livingstone P G,De Lisle G W.Advances in ante-mortem diagnosis of tuberculosis in cattle[J].New Zealand Veterinary Journal,2009,57(4):173-180.
[18] Amos W,Brooks-Pollock E,Blackwell R,et al.Genetic predisposition to pass the standard SICCT test for bovine tuberculosis in British cattle[J].PloS One,2013,8(3):e58245.
[19] De La Rua-Domenech R,Goodchild A,Vordermeier H,et al.Ante mortem diagnosis of tuberculosis in cattle:A review of the tuberculin tests,γ-interferon assay and other ancillary diagnostic techniques[J].Research in Veterinary Science,2006,81(2):190-210.
[20] Pollock J,Welsh M,Mcnair J.Immune responses in bovine tuberculosis:Towards new strategies for the diagnosis and control of disease[J].Veterinary Immunology and Immunopathology,2005,108(1/2):37-43.
[21] Tiwari D,Tiwari R P,Chandra R,et al.Efficient ELISA for diagnosis of active tuberculosis employing a cocktail of secretory proteins of Mycobacterium tuberculosis[J].Folia Biologica,2014,60(1):10-20.
[22] Napp S,Ciaravino G,De Val B P,et al.Evaluation of the effectiveness of the surveillance system for tuberculosis in cattle in Spain[J].Preventive Veterinary Medicine,2019,173:104805.
[23] Goodman C M.The Delphi technique:A critique[J].Journal of Advanced Nursing,1987,12(6):729-734.
[24] 后永春,王敏,李晓倩,等.中国结核病监测预警指标体系的构建[J].中华流行病学杂志,2012,33(5):505-508.
[25] 卢亮平,王丽,马芬,等.肾综合征出血热流行预警指标体系研究[J].中华预防医学杂志,2011,45(3):235-238.
[26] 廖如燕,陈胤瑜,毛琛.构建输入性登革热风险预警量化指标体系的研究[J].中华疾病控制杂志,2009,13(3):337-341.
[27] Birch C P D,Goddard A,Tearne O.A new bovine tuberculosis model for England and Wales(BoTMEW) to simulate epidemiology,surveillance and control[J].BMC Veterinary Research,2018,14(1):273.
[28] Brooks-Pollock E,Roberts G O,Keeling M J.A dynamic model of bovine tuberculosis spread and control in Great Britain[J].Nature,2014,511(7508):228-231.
[29] Conteddu K,English H M,Byrne A W,et al.A scoping review on bovine tuberculosis highlights the need for novel data streams and analytical approaches to curb zoonotic diseases[J].Veterinary Research,2024,55(1):64.
[30] Kao R R,Roberts M G,Ryan T J.A model of bovine tuberculosis control in domesticated cattle herds[J].Proceedings. Biological Sciences,1997,264(1384):1069-1076.
[31] O'Hare A,Orton R J,Bessell P R,et al.Estimating epidemiological parameters for bovine tuberculosis in British cattle using a Bayesian partial-likelihood approach[J].Proceedings of the Royal Society B:Biological Sciences,2014,281(1783):20140248.
[32] Conlan A J K,McKinley T J,Karolemeas K,et al.Estimating the hidden burden of bovine tuberculosis in Great Britain[J].Plos Computational Biology,2012.
[33] Welby S,Govaerts M,Vanholme L,et al.Bovine tuberculosis surveillance alternatives in Belgium[J].Preventive Veterinary Medicine,2012,106(2):152-161.
[34] Fischer E A,Van Roermund H J,Hemerik L,et al.Evaluation of surveillance strategies for bovine tuberculosis(Mycobacterium bovis) using an individual based epidemiological model[J].Prev Vet Med,2005,67(4):283-301.
[35] Smith R L,Schukken Y H,Lu Z,et al.Development of a model to simulate infection dynamics of Mycobacterium bovis in cattle herds in the United States[J].Journal of the American Veterinary Medical Association,2013,243(3):411-423.
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