[目的] 探究自拟中药复方制剂对奶牛乳房炎的防控效果。[方法] 本试验测定该复方对奶牛乳房炎主要病原菌的体外抑菌活性,并开展临床疗效评价。[结果] 该中药复方对金黄色葡萄球菌、无乳链球菌的最低抑菌浓度（MIC）均为31.25 mg/mL,对大肠杆菌MIC为62.5 mg/mL,判定为中度敏感。不同药物干预结果表明,中药复方高剂量组临床有效率、治愈率最高,分别达100%、83.33%;其次为抗生素组,有效率83.33%、治愈率66.67%;中药复方中剂量组有效率为66.67%;中药复方低剂量组效果最差,有效率50%、治愈率16.67%。用药后,各组牛乳体细胞数（SCC）均显著下降（P<0.05）;其中中剂量组、高剂量组与抗生素组牛乳SCC均低于20 万个/mL,依次为19.35±0.32、11.32±0.44、14.52±0.21 万个 /mL。相较于空白对照组,各用药组奶牛日均采食量显著提升（P<0.05）;中药复方中、高剂量组产奶量显著增加（P<0.05）,奶料比呈上升趋势（P>0.05）。[结论] 该中药复方可有效抑制金黄色葡萄球菌、无乳链球菌与大肠杆菌增殖,对奶牛乳房炎具备良好治疗作用,能够显著降低牛乳体细胞数;高剂量复方疗效优于常规抗生素,同时可提升患病奶牛采食量与产奶量,改善机体健康状态。

[Objective] To investigate the preventive and therapeutic effects of a self-formulated traditional Chinese medicine compound on bovine mastitis. [Method] The in vitro antibacterial activity of this compound against the main pathogens causing bovine mastitis was determined,and its clinical efficacy was evaluated. [Result] The minimum inhibitory concentration （MIC） of the traditional Chinese medicine compound against Staphylococcus aureus and Streptococcus agalactiae was 31.25 mg/mL,and the MIC against Escherichia coli was 62.5 mg/mL,indicating moderate sensitivity. The results of different drug interventions showed that the high-dose group of the traditional Chinese medicine compound had the highest clinical efficacy and cure rate,reaching 100% and 83.33%,respectively; followed by the antibiotic group,with an efficacy rate of 83.33% and a cure rate of 66.67%; the medium-dose group of the traditional Chinese medicine compound had an efficacy rate of 66.67%; and the low-dose group of the traditional Chinese medicine compound had the worst effect,with an efficacy rate of 50% and a cure rate of 16.67%. After medication,the somatic cell count （SCC） of milk in all groups decreased significantly （P< 0.05）; among them,the SCC of milk in the medium-dose group,high-dose group,and antibiotic group were all below 200000 cells/mL,namely 19.35±0.32,11.32±0.44,and 14.52±0.21×104 cells/mL,respectively. Compared with the blank control group,the average daily feed intake of dairy cows in each medication group increased significantly （P<0.05）; the milk yield of the medium and high dose groups of the traditional Chinese medicine compound increased significantly （P<0.05）,and the milk-to-feed ratio showed an upward trend （P>0.05）.[Conclusion] This traditional Chinese medicine compound can effectively inhibit the proliferation of Staphylococcus aureus,Streptococcus agalactiae,and Escherichia coli,and has a good therapeutic effect on mastitis in dairy cows,which can significantly reduce the somatic cell count of milk; the high-dose compound is more effective than conventional antibiotics,and can also increase the feed intake and milk yield of sick dairy cows,and improve their health status.