China Dairy ›› 2021, Vol. 0 ›› Issue (10): 55-60.doi: 10.12377/1671-4393.21.10.12

• EXPERIMENTAL STUDY • Previous Articles     Next Articles

Effects of Different Doses of 25-hydroxyvitamin D3 on Blood Biochemical Indices,Antioxidant Capacity and Immune Function of Pre-weaning Calves

WANG Lihua, XU Hongjian, ZHANG Quanyu, ZHANG Chengrui, ZHANG Yonggen*   

  1. College of Animal Sciences and Technology,Northeast Agriculture University,Harbin Heilongjing 150030
  • Online:2021-10-25 Published:2021-12-03

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Abstract: To study the effects of 25-hydroxyvitamin D3 [25(OH)VD3] at different doses on blood level, antioxidant capacity and immune function of pre-weaning calves,18 healthy Holstein calves were randomly assigned to 3 groups with 6 calves in each group for 56 days. They were divided into control group [0 IU 25(OH)VD3 per calf per day], low-dose group [6 000 IU 25(OH)VD3 per calf per day] and high-dose group [12 000 IU 25(OH)VD3 per calf per day]. The results showed that compared with the control group, the contents of plasma growth hormone, insulin-like growth factor-1, catalase, superoxide dismutase,total antioxidant capacity and immunoglobulin G (IgG) were significantly increased (P<0.05) with the increasing dose of 25(OH)VD3. The content of malondialdehyde decreased with the dosage of 25(OH)VD3 increased (P=0.079). Compared with the control group and the low-dose group, the plasma immunoglobulin A (IgA) content in the high-dose group had an increasing trend (P=0.059). In conclusion,feeding high doses of 25(OH)VD3 to calves before weaning can promote the secretion of growth hormone and insulin-like growth factor-1,improve antioxidant capacity, and enhance immune function.

Key words: calf, 25-hydroxyvitamin D3, antioxidant capacity, immune function

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