基因组选择背景下奶牛体外受精的40 年

doi:10.12377/1671-4393.21.06.03

中国乳业 ›› 2021, Vol. 0 ›› Issue (6): 16-22.doi: 10.12377/1671-4393.21.06.03

基因组选择背景下奶牛体外受精的40 年

蔡高占¹, 张汝美¹, 王亚琴², 黄国锋³, 李俊婷⁴, 刘小涛⁵, 姚文龙⁶, 周浩⁴, 李建斌¹, 仲跻峰^1,*

1 山东省农业科学院畜牧兽医研究所,山东济南 250100;
2 宁波市农业村局,浙江宁波 315033;
3 余姚市陆埠镇农业农村办公室,浙江余姚 315420;
4 宁波市鄞州区农业农村局,浙江宁波 315100;
5 宁波市牛奶集团有限公司,浙江宁波 315033;
6 宁波市鄞州瞻岐鹰山牛场,浙江宁波 315100

出版日期:2021-06-25 发布日期:2021-07-08
通讯作者: ^*仲跻峰（1964-）,男,江苏南京人,博士,研究员,研究方向为动物遗传育种与繁殖。
作者简介:蔡高占（1989-）,男,山东菏泽人,硕士,助理研究员,研究方向为动物遗传育种与繁殖;张汝美（1969-）,女,山东临清人,农艺师,研究方向为动物遗传育种与繁殖;王亚琴（1966-）,女,浙江象山人,农业推广硕士,推广研究员,研究方向为品种选育、种草养畜和饲草资源化利用;黄国锋（1968-）,男,浙江余姚人,本科,兽医师,研究方向为动物饲养管理与疫病防控;李俊婷（1980-）,女,山西临汾人,硕士,畜牧师,研究方向为畜牧;刘小涛（1978-）,男,浙江宁波人,本科,工程师,研究方向为乳品技术和工程;姚文龙（1965-）,男,浙江宁波人,牛场负责人,研究方向为肉牛养殖;周浩（1973-）,男,浙江宁波人,兽医师,研究方向为动物医学;李建斌（1974-）,男,河北承德人,博士,研究员,研究方向为动物遗传育种与繁殖。
基金资助:
财政部和农业农村部：“国家现代农业产业技术体系资助”（项目编号：CARS-36）; 北沙牛遗传物质保存与人工授精技术应用示范（项目编号：2019AS0010）; 奶牛高产核心群及β酪蛋白A2型高端品系选育与示范（项目编号：2019B10018）; 山东省农业科学院农业科技创新工程项目（CXGC2021A32）

40 Years of Bovine IVF in the Context of Genome Selection

CAI Gaozhan¹, ZHANG Rumei¹, WANG Yaqin², HUANG Guofeng³, LI Junting⁴, LIU Xiaotao⁵, YAO Wenlong⁶, ZHOU Hao⁴, LI Jianbin¹, ZHONG Jifeng^1,*

¹Institute of animal husbandry and veterinary medicine,Academy of Agricultural Sciences,Jinan Shandong 250100;
²Agricultural village Bureau,Ningbo Zhejiang 315033;
³Agricultural and rural Office of Lubu Town,Yuyao Zhejiang 315420;
⁴Agricultural and rural Bureau of Yinzhou District,Ningbo Zhejiang 315100;
⁵Ningbo Milk Group Co.,Ltd,Ningbo Zhejiang 315033;
⁶Yingshan cattle farm,Zhanqi Town,Yinzhou District,Ningbo Zhejiang 315100

Online:2021-06-25 Published:2021-07-08

摘要/Abstract

摘要： 体外受精（In Vitro Fertilization,IVF）等复杂技术的发展需要多年的试验,有时需要比较几个物种,以了解如何为卵母细胞、精子和早期胚胎创造合适的体外环境。配子生理机能和配子交互作用等物种特征是最近才进化出来的性状,必须在各自物种的背景下加以分析。世界首例试管婴儿Louise Brown出生后的近40 年里,IVF技术取得了很大进步,目前已在世界各地多种家养和非家养动物物种中得到应用。但这并不意味着该技术完全成熟或令人满意,还有许多问题需要解决,还有若干程序需要优化。自从IVF技术允许商业化开发以后,奶牛IVF的发展尤其引人关注,其使用规模堪比人类的体外受精（数百万新生儿）。犊牛甚至是胚胎的基因组选择与性别鉴定和冷冻技术相结合,正推动奶牛IVF进入一个新时代。本文回顾了过去40 年奶牛IVF取得的成绩和存在的困难,并提出了未来几年所面临的挑战。

关键词: 基因组选择, 体外受精（IVF）, 奶牛, 进展

Abstract: The development of complex technologies such as in vitro fertilization (IVF) needs many years of experiments,sometimes it is necessary to compare several species,to understand how to create a suitable in vitro environment for oocytes,sperm and early embryos.The physiological function of gametes and gamete interaction are recently evolved traits,which must be analyzed in the context of each species.In the past 40 years after Louis Brown was born,IVF technology has made great progress and has been applied in a variety of domestic and non domestic animal species all over the world. However,this does not mean that the technology is completely mature or satisfactory.There are still many problems to be solved and some programs to be optimized.Since IVF technology was allowed to be commercialized,the development of cow IVF has attracted special attention.Its scale of use is comparable to that of human IVF (millions of newborns).The combination of genomic selection,sex identification and cryopreservation of calves and even embryos is pushing IVF into a new era.This paper reviews the success and shortcomings of IVF in cattle in the past 40 years, and describes the challenges to be overcome in the next few years.

Key words: genome selection, in vitro fertilization, cow, progress

蔡高占, 张汝美, 王亚琴, 黄国锋, 李俊婷, 刘小涛, 姚文龙, 周浩, 李建斌, 仲跻峰. 基因组选择背景下奶牛体外受精的40 年[J]. 中国乳业, 2021, 0(6): 16-22.

CAI Gaozhan, ZHANG Rumei, WANG Yaqin, HUANG Guofeng, LI Junting, LIU Xiaotao, YAO Wenlong, ZHOU Hao, LI Jianbin, ZHONG Jifeng. 40 Years of Bovine IVF in the Context of Genome Selection[J]. China Dairy, 2021, 0(6): 16-22.

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基因组选择背景下奶牛体外受精的40 年

40 Years of Bovine IVF in the Context of Genome Selection

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