中国乳业 ›› 2026, Vol. 0 ›› Issue (3): 62-67.doi: 10.12377/1671-4393.26.03.09

• 疾病防治 • 上一篇    下一篇

透明质酸联合青霉素抑制金黄色葡萄球菌活性的研究

王倩1, 贾芳1,2, 崔红宇3, 赵丽霞1,2,*   

  1. 1.内蒙古医科大学基础医学院,内蒙古呼和浩特 010110;
    2.国家乳业技术创新中心,内蒙古呼和浩特 010080;
    3.内蒙古医科大学第一临床医学院,内蒙古呼和浩特 010110
  • 出版日期:2026-03-25 发布日期:2026-04-09
  • 通讯作者: *赵丽霞（1979-）,女,内蒙古巴彦淖尔人,博士,研究员,研究方向为动物干细胞生物学。
  • 作者简介:王 倩（1999-）,女,山东商河人,在读硕士,研究方向为干细胞分化;贾 芳（1980-）,女,内蒙古乌兰察布人,博士,副教授,研究方向为病原生物学;崔红宇（2000-）,女,山西吕梁人,在读硕士,初级执业医师,研究方向为干细胞分化。
  • 基金资助:
    国家乳业技术创新中心开放课题（2024-KFKT-036）

The Inhibitory Effects of Hyaluronic Acid Combined with Penicillin on Staphylococcus aureus Activity

WANG Qian1, JIA Fang1,2, CUI Hongyu3, ZHAO Lixia1,2,*   

  1. 1. School of Basic Medical Sciences,Inner Mongolia Medical University,Hohhot Inner Mongolia 010110;
    2. National Center of Technology Innovation for Dairy,Hohhot Inner Mongolia 010080;
    3. The First Clinical Medical College,Inner Mongolia Medical University,Hohhot Inner Mongolia 010110
  • Online:2026-03-25 Published:2026-04-09

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摘要： [目的]检测透明质酸（HA）单独及与青霉素（PEN）联合使用时,对金黄色葡萄球菌（金葡菌）的抗菌活性,并同步检测多种抗生素对该菌的药敏性。[方法]采用二倍稀释法和微量棋盘法,评估1 株金葡菌标准株与9 株奶牛源临床分离金葡菌对相关药物的敏感性。[结果]金葡菌对PEN、克林霉素、红霉素的耐药率分别为90%、80%和40%;未检测出耐甲氧西林菌株,诱导克林霉素耐药菌株占比40%;HA与PEN联合作用于金葡菌时,均表现出相加（部分抑菌浓度指数FICI 0.5~1.0）或协同（FICI≤0.5）效应。[结论]HA与PEN联用可显著降低2 种药物对金葡菌的有效抑菌浓度,为临床应对金葡菌耐药问题提供新的用药思路。

关键词: 透明质酸（HA）, 青霉素（PEN）, 金黄色葡萄球菌（金葡菌）, 最小抑菌浓度（MIC）

Abstract: [Objective] To investigate the antibacterial activities of several antibiotics,hyaluronic acid（HA） alone,and HA combined with penicillin （PEN） against Staphylococcus aureus（S.aureus）. [Method] The susceptibility of 1 standard strain and 9 clinical S.aureus strains isolated from dairy cattle to antimicrobial agents was evaluated using the double-dilution method and the micro-checkerboard method. [Result] The resistance rates of S.aureus to PEN,clindamycin and erythromycin were 90%,80% and 40%,respectively. No methicillin-resistant strains were detected,and 40% of the strains showed inducible clindamycin resistance. The combination of HA and PEN exhibited either additive effect （FICI 0.5~1.0） or synergistic effect （FICI≤0.5） against all tested S. aureus strains. [Conclusion] The combination of HA and PEN can significantly reduce the effective minimal inhibitory concentration of both agents against S.aureus,which provides a new idea for the clinical treatment of drug-resistant S.aureus infections.

Key words: hyaluronic acid（HA）, penicillin（PEN）, Staphylococcus aureus（S.aureus）, minimal inhibitory concentration（MIC）

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