配方羊奶粉对小鼠免疫功能影响的研究

doi:10.12377/1671-4393.21.12.24

中国乳业 ›› 2021, Vol. 0 ›› Issue (12): 133-136.doi: 10.12377/1671-4393.21.12.24

配方羊奶粉对小鼠免疫功能影响的研究

杨鹏飞¹, 吴桐², 谢奎², 邓友田¹, 蒋飞荣¹, 卢素云¹, 侯艳梅^2,*

1 湖南安生美药物研究院有限公司,湖南长沙 410000;
2 海普诺凯营养品有限公司,湖南长沙 410000

出版日期:2021-12-25 发布日期:2022-01-07
通讯作者: ^*侯艳梅（1981-）,湖南长沙人,高级工程师,硕士,研究方向为乳品科学。
作者简介:杨鹏飞（1989-）,男,河南长葛人,硕士,研究方向为食品营养与安全、药理毒理;吴桐（1987-）,女,四川成都人,硕士,研究方向为食品营养,乳制品生产工艺;谢奎（1986-）,男,湖南常德人,博士,研究方向为食品营养,分子营养;邓友田（1981-）,女,湖南长沙人,硕士,研究方向为药理毒理;蒋飞荣（1984-）,男,湖南长沙人,硕士,研究方向为药理毒理;卢素云（1988-）,女,湖南邵阳人,硕士,研究方向为药理毒理

Study on the Effect of Goat Milk Formula on the Immune Function on Mice

YANG Pengfei, WU Tong, XIE Kui, DENG Youtian, JIANG Feirong, LU Suyun, HOU Yanmei^*

¹Hunan Anshengmei Drug Research Institute Co. Ltd,Hunan Changsha 410000;
²Hyproca Nutrition Co.Ltd,Hunan Changsha 410000

Online:2021-12-25 Published:2022-01-07

摘要/Abstract

摘要： 选用雄性BALB/c小鼠,通过腹腔注射环磷酰胺,构建免疫功能低下小鼠模型,评价益生菌+益生元配方羊奶粉和高钙富硒配方羊奶粉对小鼠免疫功能的影响。结果显示,益生菌+益生元配方羊奶粉和高钙富硒配方羊奶粉均可明显增强免疫低下小鼠脾淋巴细胞增殖能力（P<0.05）、自然杀伤细胞（NK）活性（P<0.01）以及碳廓清试验吞噬指数（P<0.01）。表明益生菌+益生元配方羊奶粉和高钙富硒配方羊奶粉对环磷酰胺致免疫力低下模型小鼠具有增强免疫力作用。

关键词: 羊奶粉, 富硒, 益生菌, 益生元, 自然杀伤细胞（NK）活性, 脾淋巴细胞增殖, 碳廓清

Abstract: Immunocompromised BALB/c mice model were established by intraperitoneal injection of cyclophosphamide in this study to evaluate the effects of goat milk-based formulated powder with probiotics and prebiotics,and goat milk-based formulated powder with high calcium-selenium of immune function in vivo. Results showed that two goat milk formula could significantly enhance the proliferation ability of spleen lymphocytes（P<0.05）,the activity of NK cells （P<0.01）and the phagocytosis index of carbon removal test（P<0.01）in immunocompromised mice,indicating that goat milk-based formulated powder with probiotics and prebiotics,and goat milk-based formulated powder with high calcium-selenium could enhance the immunity of mice with immunodeficiency induced by cyclophosphamide.

Key words: goat milk formula, selenium, probiotics, prebiotics, proliferation of spleen lymphocytes, activity of NK cells, carbon removal

杨鹏飞, 吴桐, 谢奎, 邓友田, 蒋飞荣, 卢素云, 侯艳梅. 配方羊奶粉对小鼠免疫功能影响的研究[J]. 中国乳业, 2021, 0(12): 133-136.

YANG Pengfei, WU Tong, XIE Kui, DENG Youtian, JIANG Feirong, LU Suyun, HOU Yanmei. Study on the Effect of Goat Milk Formula on the Immune Function on Mice[J]. China Dairy, 2021, 0(12): 133-136.

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配方羊奶粉对小鼠免疫功能影响的研究

Study on the Effect of Goat Milk Formula on the Immune Function on Mice

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