中国乳业 ›› 2024, Vol. 0 ›› Issue (4): 91-95.doi: 10.12377/1671-4393.24.04.17

• 乳品加工 • 上一篇    下一篇

乳品的营养成分及免疫调节功能

王芯媛, 姬玉梅   

  1. 鹤壁职业技术学院/鹤壁市绿色食品精深加工重点实验室,河南鹤壁 458030
  • 出版日期:2024-04-25 发布日期:2024-05-24
  • 作者简介:王芯媛(1997-),女,河南鹤壁人,硕士,助教,研究方向为食品加工与安全;姬玉梅(1975-),女,河南新乡人,本科,教授,研究方向为粮食油脂加工。
  • 基金资助:
    鹤壁职业技术学院科技类重点课题(2024-KJZD-008)

Nutritional Components and Immunomodulatory Activity of Dairy Products

WANG Xinyuan, JI Yumei   

  1. Hebi Polytechnic,Hebi Key Laboratory of Green Food Deep Processing,Hebi Henan 458030
  • Online:2024-04-25 Published:2024-05-24

摘要: 牛乳富含蛋白质、脂肪、维生素和矿物质等营养素,包括乳铁蛋白、免疫球蛋白、溶菌酶和过氧化物酶等多种生物活性物质,可调节机体免疫功能,增强免疫力。乳源活性肽是源自乳蛋白的功能性肽段,具有免疫调节作用,近年成为国内外研究热点。发酵乳是酸性乳制品的统称,风味独特,易于吸收,并能调节肠道功能、增强机体免疫力。本文系统阐述牛乳中营养成分以及乳蛋白肽和发酵乳的免疫调节功能,加深对牛乳营养与功能认识。

关键词: 牛乳, 营养, 免疫调节, 乳蛋白肽, 发酵乳

Abstract: Milk is rich in protein, fat, vitamins and minerals, It contains many bioactive substances, including lactoferrin, immunoglobulin, lysozyme and peroxidase, which can regulate immune function and enhance immunity.Milk-derived bioactive peptides are functional peptides derived from milk proteins, which have immunomodulatory effects and have become a research hotspot at home and abroad in recent years.Fermented milk is a general term for acidic dairy products.It has a unique flavor, is easy to absorb, and can regulate intestinal function and enhance body immunity.This paper systematically elaborated the nutritional components in milk and the immunomodulatory function of milk protein peptides and fermented milk to deepen the understanding of milk nutrition and function.

Key words: milk, nutrition, immunomodulation, milk protein peptide, fermented milk

[1] 王磊,成雪,毛学英.乳清蛋白及其活性多肽的生物学功能研究进展[J].中国农业科技导报,2010,12(5):30-35.
[2] Lopez C,Briard-Bion V,Ménard O,et al.Fat globules selected from whole milk according to their size:Different compositions and structure of the biomembrane,revealing sphingomyelin-rich domains[J].Food Chemistry,2011,125(2):355-368.
[3] Fong B Y,Norris C S,Macgibbon A K H.Protein and lipid composition of bovine milk-fat-globule membrane[J].International Dairy Journal,2007,17(4):275-288.
[4] Li T,Jing G,Du M,et al.Milk fat globule membrane attenuates high-fat diet-induced obesity by inhibiting adipogenesis and increasing uncoupling protein 1 expression in white adipose tissue of mice[J].Nutrients,2018,10(3):331.
[5] Yuan Q,Zhan B,Du M,et al.Dietary milk fat globule membrane regulates JNK and PI3K/Akt pathway and ameliorates type 2 diabetes in mice induced by a high-fat diet and streptozotocin[J].Journal of Functional Foods,2019,60:103435.
[6] 王艺苑,林姗姗,热依拉·阿巴拜克热,等.不同浓度低聚半乳糖对初断乳大鼠肠道菌群的影响[J].食品研究与开发,2019,40(5):17-22.
[7] Brimelow R E,West N P,Williams L T,et al.A role for whey-derived lactoferrin and immunoglobulins in the attenuation of obesity-related inflammation and disease[J].Critical Reviews in Food Science and Nutrition,2017,57(8):1593-1602.
[8] Legrand D,Elass E,Carpentier M,et al.Lactoferrin:A modulator of immune and inflammatory responses[J].Cellular and Molecular Life Sciences,2005,62(22):2549-2559.
[9] Francesco G,Gloria P,Loris L,et al.Lactoferrin from milk:Nutraceutical and pharmacological properties[J].Pharmaceuticals,2016,9(4):61.
[10] Dix C,Wright O.Bioavailability of a novel form of microencapsulated bovine lactoferrin and its effect on inflammatory markers and the gut microbiome:A pilot study[J].Nutrients,2018,10(8):1115.
[11] Esmaeili A,Sotoudeh E,Morshedi V,et al.Effects of dietary supplementation of bovine lactoferrin on antioxidant status,immune response and disease resistance of yellowfin sea bream(Acanthopagrus latus) against Vibrio harveyi[J].Fish & Shellfish Immunology,2019,93:917-923.
[12] Heidebrecht H,Weiss W J,Pulse M,et al.Treatment and prevention of recurrent clostridium difficile infection with functionalized bovine antibody-enriched whey in a hamster primary infection model[J].Toxins,2019,11(2):98.
[13] Splunter M,Osch T,Brugman S,et al.Induction of trained innate immunity in human monocytes by bovine milk and milk-derived immunoglobulin G[J].Nutrients,2018,10(10):1378.
[14] Ohnuki H,Mizutani A,Otani H.Oral ingestion of cow's milk immunoglobulin G stimulates some cellular immune systems and suppresses humoral immune responses in mouse[J].International Immunopharmacology,2006,6(8):1315-1322.
[15] Tacket C O,Binion S B,Bostwick E,et al.Efficacy of bovine milk immunoglobulin concentrate in preventing illness after Shigella flexneri challenge[J].American Journal of Tropical Medicine and Hygiene,1992,47(3):276-283.
[16] 秦兰霞. 牛初乳粉中免疫球蛋白IgG增强免疫力功能的研究[J].现代食品,2018(17):111-115.
[17] Xiong X,Zhou J,Liu H,et al.Dietary lysozyme supplementation contributes to enhanced intestinal functions and gut microflora of piglets[J].Food & Function,2019,10(3):1696-1706.
[18] Chatterton D E W,Nguyen D N,Bering S B,et al.Anti-inflammatory mechanisms of bioactive milk proteins in the intestine of newborns[J].The International Journal of Biochemistry & Cell Biology,2013,45(8):1730-1747.
[19] Liang N,Beverly R L,Scottoline B P,et al.Peptides derived from in vitro and in vivo digestion of human milk are immunomodulatory in THP-1 human macrophages[J].The Journal of Nutrition,2022,152(1):331-342.
[20] LI T,GAO D,Du M,et al.Casein glycomacropeptide hydrolysates inhibit PGE2 production and COX2 expression in LPS-stimulated RAW 264.7 macrophage cells via Akt mediated NF-kappa B and MAPK pathways[J].Food & Function,2018,9(4):2524-2532.
[21] 高婧昕,李天歌,郭凯睿,等.乳酸菌发酵对乳清蛋白酶解物风味和免疫调节活性的影响[J].中国食品学报,2021,21(8):258-264.
[22] Saint-sauveur D,Gauthier S F,Boutin Y,et al.Immunomodulating properties of a whey protein isolate,its enzymatic digest and peptide fractions[J].International Dairy Journal,2008,18(3):260-270.
[23] Rocha-Ramírez LM,Hernández-Chiñas U,Moreno-Guerrero SS,et al.Probiotic properties and immunomodulatory activity of Lactobacillus strains isolated from dairy products[J].Microorganisms,2021,9(4):825.
[24] Meng H,Ba Z,Lee Y,et al.Consumption of Bifidobacterium animalis subsp. lactis BB-12 in yogurt reduced expression of TLR-2 on peripheral blood-derived monocytes and pro-inflammatory cytokine secretion in young adults[J].European Journal of Nutrition,2017,56(2):649-661.
[25] Larsen C,Nielsen S,Kaestel P,et al.Dose-response study of probiotic bacteria Bifidobacterium animalis subsp lactis BB-12 and Lactobacillus paracasei subsp paracasei CRL-341 in healthy young adults[J].European Journal of Clinical Nutrition,2006,60(11):1284-1293.
[26] Huang S,Chen K,Chen Y,et al.Immunomodulatory properties of the milk whey products obtained by enzymatic and microbial hydrolysis[J].International Journal of Food Science & Technology,2010,45(5):1061-1067.
[27] Pei R,Martin D A,Dimarco D M,et al.Evidence for the effects of yogurt on gut health and obesity[J].Critical Reviews in Food Science and Nutrition,2017,57(8):1569-1583.
[28] Zhai Z,Wang J,Huang B,et al.Low-fat yogurt alleviates the pro-inflammatory cytokine IL-1β-induced intestinal epithelial barrier dysfunction[J].Journal of Dairy Science,2019,102(2):976-984.
[29] Pei R,Dimarco D M,Putt K K,et al.Low-fat yogurt consumption reduces biomarkers of chronic inflammation and inhibits markers of endotoxin exposure in healthy premenopausal women:A randomised controlled trial[J].British Journal of Nutrition,2017,118(12):1043-1051.
[30] Araujo G V,Lorena V M B,Montenegro S M L,et al.Probiotics as an adjunct for the treatment of recurrent wheezing in infants and effects on expression of T-helper 1 and regulatory T cytokines[J].Journal of Functional Foods,2017,35:398-407.
[31] Maciel F R,Punaro G R,Rodrigues A M,et al.Immunomodulation and nitric oxide restoration by a probiotic and its activity in gut and peritoneal macrophages in diabetic rats[J].Clinical Nutrition,2016,35(5):1066-1072.
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