人乳脂替代品在婴幼儿配方奶粉中的研究进展

摘要/Abstract

摘要： 母乳可为婴幼儿提供人生最初阶段生长发育所需的全部营养。人乳脂替代品实质上是婴幼儿配方奶粉专用的一类食用油脂及其制品,普通婴幼儿配方奶粉主要以牛乳为原料,虽然牛乳脂肪酸组成与人乳脂肪酸相近,但其脂肪酸结构与人乳存在差异。在介绍人乳脂肪的组成结构特点、营养特性以及婴幼儿对脂肪消化吸收特点的基础上,进一步综述近年来人乳脂替代品的母乳化进程及制备技术方面的研究进展,并对人乳脂替代品的发展前景进行展望,旨在为开发脂肪方面更接近母乳的婴幼儿配方奶粉提供有益参考。

关键词: 人乳脂肪, 人乳脂替代品, 母乳化, 婴幼儿配方奶粉

王青云, 王帅, 孙健. 人乳脂替代品在婴幼儿配方奶粉中的研究进展[J]. 中国乳业, 2019, 0(5): 65-70.

参考文献

[1] 李晓南,彭璐婷.关注患病婴幼儿母乳喂养的指导[J].中华实用儿科临床杂志,2017,32(23):1766-1769.
[2] Alev Yüksel,Yesilcubuk N S.Enzymatic production of human milk fat analogues containing stearidonic acid and optimization of reactions by response surface methodology[J].LWT-Food Science and Technology,2012,46(1):210-216.
[3] Giovannini M,Riva E,Agostoni C.Fatty acids in pediatric nutrition[J].Pediatric Clinics of North America,1995,42(4):861-877.
[4] Nagachinta S,Akoh C C.Enrichment of palm olein with long chain polyunsaturated fatty acids by enzymatic acidolysis[J].LWT-Food Science and Technology,2012,46(1):29-35.
[5] Koletzko B,Rodriguezpalmero M,Demmelmair H,et al.Physiological aspects of human milk lipids[J].Early Human Development,2001,65(1):S3-S18.
[6] 孙健.婴幼儿奶粉配方设计及其生产与贮存对营养素稳定性影响:[硕士论文][D].哈尔滨:哈尔滨工业大学,2016
[7] Li Y Q,Mu H L,Andersen J E T,et al.New human milk fat substitutes from butterfat to improve fat absorption.[J].Food Research International,2010,43(3):739-744.
[8] Yang T,Xu X,He C,et al.Lipase-catalyzed modification of lard to produce human milk fat substitutes[J].Food Chemistry,2003,80(4):473-481.
[9] Poncebravo S,Ledesmamontes C,Garcésortíz M.MUC-1expression in pleomorphic adenomas using two human milk fat globule protein membrane antibodies(HMFG-1 and HMFG-2)[J].Journal of Applied Oral Science Revista Fob,2015,23(3):265-271.
[10] 杨洁,齐策,韦伟.人乳脂肪球的研究进展[J].中国油脂,2018,43(5):33-38.
[11] Mu H,Høy C E.The digestion of dietary triacylglycerols.[J].Progress in Lipid Research,2004,43(2):105-133.
[12] 王兴国.人乳脂及人乳替代脂[M].北京:科学出版社,2017.
[13] 韩瑞丽,马健,张佳程,等.棕榈酸在甘油三酯中的位置分布对婴幼儿营养吸收的影响[J].中国粮油学报,2009,24(5):80-83.
[14] 曹栋,裘爱泳,王兴国.磷脂结构、性质、功能及研究现状(1)[J].粮食与油脂,2004(5):3-6.
[15] Gallier S,Gragson D,Jimenez -Flores R,et al.Using Confocal Laser Scanning Microscopy To Probe the Milk Fat Globule Membrane and Associated Proteins[J].Journal of Agricultural and Food Chemistry,2010,58(7):4250-4257.
[16] Garcia C,Lutz N W,Confort Gouny S,et al.Phosphlipid fingerprints of milk from different mamalians determined by 31P NMR :towards specific interest in human health[J].Food Chemistry,2012,135(3):1777-1783.
[17] Simone R D,Ajmonecat M A,Minghetti L.Atypical antiinflammatory activation of microglia induced by apoptotic neurons[J].Molecular Neurobiology,2004,29(2):197-212.
[18] Pepeu G,Pepeu I M,Amaducci L.A review of phosphatidylserine pharmacological and clinical effects.Is phosphatidylserine a drug for the ageing brain?[J].Pharmacological Research the Official Journal of the Italian Pharmacological Society,1996,33(2):73-80.
[19] Zeisel S H.The fetal origins of memory:The role of dietary choline in optimal brain development[J].Journal of Pediatrics,2006,149(5-supp-S)S131-6.
[20] Timby N,Domellöf E,Hernell O,et al.Neurodevelopment,nutrition,and growth until 12 mo of age in infants fed a low-energy,low-protein formula supplemented with bovine milk fat globule membranes:a randomized controlled trial[J].American Journal of Clinical Nutrition,2014,99(4):860-868.
[21] Tanaka K,Hosozawa M,Kudo N,et al.The pilot study:sphingomyelin-fortified milk has a positive association with the neurobehavioural development of very low birth weight infants during infancy,randomized control trial.[J].Brain and Development,2013,35(1):45-52.
[22] 孟菂,吴圣楣,张伟利,等.含中链甘油三酯脂肪乳剂的基础与临床研究进展[J].中华临床营养杂志,1996(3):28-31.
[23] 杨慧明,吴康敏.多不饱和脂肪酸与婴幼儿的健康和疾病[J].国际儿科学杂志,2002,29(3):153-155.
[24] Innis,Sheila M.Dietary(n-3)Fatty Acids and Brain Development[J].The Journal of Nutrition,2007,137(4):855-859.
[25] El-Khayat H,Shaaban S,Emam E K,et al.Cognitive functions in protein-energy malnutrition:in relation to long chain-polyunsaturated fatty acids[J].Pakistan Journal of Biological Sciences,2007,10(11):1773-1781.
[26] Hoffman D R,Boettcher J A,Diersen-Schade D A .Toward optimizing vision and cognition in term infants by dietary docosahexaenoic and arachidonic acid supplementation:a review of randomized controlled trials.[J].Prostaglandins Leukotrienes &Essential Fatty Acids,2009,81(2):151-158.
[27] Sharma A A,Jen R,Butler A,et al.The developing human preterm neonatal immune system:A case for more research in this area[J].Clinical Immunology,2012,145(1):61-68.
[28] 金青哲,王兴国.几种重要微生物油脂在食品及饲料工业中的应用[J].中国油脂,2011,36(2):48-52.
[29] 姜中航,付国红,孙志岩,等.模拟母乳及婴幼儿配方奶粉的研究[J].中国乳品工业,2002,30(5):100-102.
[30] 戴智勇,莫红卫,董玲,等.第四代婴幼儿配方奶粉的研制及应用[J].中国乳业,2015(2):65-68.
[31] 梁媛,王昕,赵婷婷,等.食品中钙吸收的机理与钙体外转化新方法探讨[J].食品研究与开发,2016,37(4):195-199.
[32] Kennedy K,Fewtrell M S,Morley R,et al.Double-blind,randomized trial of a synthetic triacylglycerol in formula-fed term infants:Effects on stool biochemistry,stool characteristics,and bone mineralization[J].American Journal of Clinical Nutrition,1999,70(5):920-927.
[33] Quinlan P T,Lockton S,Irwin J,et al.The Relationship between Stool Hardness and Stool Composition in Breast-and Formula-Fed Infants[J].Journal of Pediatric Gastroenterology and Nutrition,1995,20(1):81-90.
[34] Sidnell A,Greenstreet E.Infant nutrition-review of lipid innovation in infant formula[J].Nutrition Bulletin,2011,36(3):373-380.
[35] 陈盛,陈景春,何亚斌.1,3-二油酸2-棕榈酸甘油三酯(OPO)检测技术综述[J].广州化工,2016(3):26-27.
[36] 赵海珍.脂肪酶催化猪油酸解制备功能性脂的研究:[博士论文][D].南京:南京农业大学,2005.
[37] Turan S,Vural H,Kayahan M,et al.Human Milk Fat Substitute Produced by Enzymatic Interesterification of Vegetable Oil Blend[J].Food Technology and Biotechnology,2007,45(4):434-438.
[38] Maduko C O,Akoh C C,Park Y W.Enzymatic interesterification of tripalmitin with vegetable oil blends for formulation of caprine milk infant formula analogs[J].Journal of Dairy Science,2007,90(2):594-601.
[39] 徐同成,王文亮,程安玮,等.甘油三酯中脂肪酸分布位置检测方法研究进展[J].粮油加工(电子版),2010(11):35-38.
[40] 王海燕,贾艾玲,曹进.人乳脂替代品1,3-二油酸-2-棕榈酸甘油三酯的研究进展[J].食品安全质量检测学报,2017,8(7):2502-2508.
[41] 张超越,辛嘉英,陈林林,等.酶法制备人乳脂替代品的研究进展[J].食品科学,2013,34(3):298-302.
[42] 李昕倩,邓利,叶贤春,等.Candida sp.99-125脂肪酶催化猪油酸解合成1,3-二油酸-2-棕榈酸甘油三酯[J].生物加工过程,2013,11(3):13-17.
[43] 何川,杨天奎.酶法猪油改性制人乳脂替代品的研究[J].中国油脂,2003,28(1):41-43.
[44] Nagachinta S,Akoh C C.Enrichment of palm olein with long chain polyunsaturated fatty acids by enzymatic acidolysis[J].LWT-Food Science and Technology,2012,46(1):29-35.
[45] Li YQ,Mu H L,Andersen J E T,et al.New human milk fat substitutes from butterfat to improve fat absorption.[J].Food Research International,2010,43(3):739-744.

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