奶牛肠道菌群紊乱与乳腺炎的关系

doi:10.12377/1671-4393.24.02.13

摘要/Abstract

摘要： 奶牛乳腺炎是养殖过程最常见疾病,对高产奶牛的生产性能、机体健康和免疫力造成巨大损害。肠道菌群和机体的多种疾病调节息息相关,肠道菌群可通过肠道-乳腺屏障进入乳房部位发挥作用,因此,针对肠道菌群稳态与乳腺炎发生发展的相关研究具有重要意义。本文阐述乳腺炎危害和传播性、肠道菌群和乳腺炎的关系与影响、乳腺菌群和肠道菌群的关联等,为更深入了解乳腺炎发病机制与防控难点提供参考。

关键词: 肠道菌群, 乳腺炎, 紊乱, 乳腺菌群

Abstract: Mastitis of dairy cows is the most common disease in breeding process, which causes great damage to the performance, body health and immunity of high-yield dairy cows. Intestinal flora is closely related to the regulation of various diseases in the body, and intestinal flora can enter the breast through the gut-breast barrier to play a role. Therefore, it is of great significance to study the homeostasis of intestinal flora and the occurrence and development of mastitis. In this paper, the harm and transmissibility of mastitis, the relationship and influence between intestinal flora and mastitis, and the association between mammary flora and intestinal flora are expounded, so as to provide references for a deeper understanding of the pathogenesis and prevention and control difficulties of mastitis.

Key words: intestinal flora, mastitis, disorder, mammary flora

陈玉山. 奶牛肠道菌群紊乱与乳腺炎的关系[J]. 中国乳业, 2024, 0(2): 65-70.

CHEN Yushan. Relationship between Intestinal Flora Disorder and Mastitis in Dairy Cows[J]. China Dairy, 2024, 0(2): 65-70.

参考文献

[1] 王志远,张学斌. 浅析奶牛乳腺炎的预防和治疗[J]. 畜牧兽医科技信息,2020(3):88.
[2] Kerr D E,Plaut K,Bramley A J,et al.Lysostaphin expression in mammary glands confers protection against staphylococcal infection in transgenic mice[J]. Nature Biotechnology,2001,19(1):66-70.
[3] Van S F,Santman I,Lam T J,et al.Failure and preventive costs of mastitis on Dutch dairy farms[J]. Journal of Dairy Science,2016,99(10):8365-8374.
[4] He W,Ma S,Lei L,et al.Prevalence,etiology,and economic impact of clinical mastitis on large dairy farms in China[J]. Veterinary Microbiology,2020,242:108570.
[5] 王飒爽,武嘉平,刘倩,等. 发酵中药添加剂对奶牛乳腺炎预防效果及其产奶性能的影响研究[J]. 饲料研究,2019,42(7):10-12.
[6] 齐晨静,沙继斌. 以肠道菌群为导向的精准饮食干预改善宿主代谢的研究进展[J]. 中国微生态学杂志,2023,35(8):985-988,993.
[7] Senchukova M A.Microbiota of the gastrointestinal tract:Friend or foe?[J]. World Journal of Gastroenterology,2023,29(1):19-42
[8] 王璟,夏杰,赵娜,等. 运动通过调节肠道菌群-肠-脑轴免疫途径改善阿尔茨海默症炎症病理的研究进展[J]. 生命科学,2022,34(5):599-607.
[9] 陈美松,张敏,周光胜,等. 奶牛乳腺炎的诊断与防治[J]. 养殖与饲料,2020(5):92-93.
[10] 肖锋. 奶牛乳腺炎的病因、临床表现和防治措施[J]. 现代畜牧科技,2019(3):112-113.
[11] 孔兴旺,霍夏辉. 规模化奶牛场奶牛亚临床型乳房炎流行规律调查[J]. 中国乳业,2022(9):37-40.
[12] 张松武,张学芳. 浅谈奶牛乳腺炎的综合防治措施[J]. 中国畜牧兽医文摘,2018,34(1):132,192.
[13] 叶宝娜,王林国,郝满良,等. 奶牛乳房炎防治措施研究进展[J]. 中国奶牛,2007(12):33-35.
[14] 丁伯良,冯建忠,张国伟. 奶牛乳房炎[M]. 北京:中国农业出版社,2011.
[15] 刘霄,胡映开,胡应武,等. 昆明市奶牛隐性乳房炎流行状况调查[J]. 中国奶牛,2019(7):40-43.
[16] 郝景锋,李心慰,刘国文. 长春地区奶牛隐性乳房炎发病情况调查与分析[J]. 黑龙江畜牧兽医,2018(20):112-115.
[17] Wang Y,Nan X,Zhao Y,et al.Discrepancies among healthy,subclinical mastitic,and clinical mastitic cows in fecal microbiome and metabolome and serum metabolome[J]. Journal of Dairy Science,2022,105(9):7668-7688.
[18] Wang Y,Nan X,Zhao Y,et al.Rumen microbiome structure and metabolites activity in dairy cows with clinical and subclinical mastitis[J]. Journal of Animal Science and Biotechnology,2021,12(3):21.
[19] Zhao C,Hu X,Bao L,et al.Gut dysbiosis induces the development of mastitis through a reduction in host anti-inflammatory enzyme activity by endotoxemia[J]. Microbiome,2022,10(1):205.
[20] Ma C,Sun Z,Zeng B,et al.Cow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis[J]. Microbiome,2018,6(1):200.
[21] Hu X,Li S,Mu R,et al.The rumen microbiota contributes to the development of mastitis in dairy cows[J]. Microbiology Spectrum,2022,10(1):e0251221.
[22] Hu X,Guo J,Zhao C,et al.The gut microbiota contributes to the development of Staphylococcus aureus-induced mastitis in mice[J]. The International Society for Microbial Ecology Journal,2020,14(7):1897-1910.
[23] Zhao C,Bao L,Zhao Y,et al.A fiber-enriched diet alleviates Staphylococcus aureus-induced mastitis by activating the HDAC3-mediated antimicrobial program in macrophages via butyrate production in mice[J]. PLoS Pathogens,2023,19(1):e1011108.
[24] Zhao C,Hu X,Bao L,et al.Aryl hydrocarbon receptor activation by Lactobacillus reuteri tryptophan metabolism alleviates Escherichia coli-induced mastitis in mice[J]. PLoS Pathogens,2021,17(7):e1009774.
[25] 陈筱筱,万华. 肠道菌群与乳腺疾病的相关性研究进展[J]. 中国微生态学杂志,2022,34(5):613-616,621.
[26] Fernandez L,Arroyo R,Espinosa I,et al.Probiotics for human lactational mastitis[J]. Beneficial Microbes,2014,5(2):169-183.
[27] Pang M,Xie X,Bao H,et al.Insights into the bovine milk microbiota in dairy farms with different incidence rates of subclinical mastitis[J]. Frontiers in Microbiology,2018,9:2379.
[28] Zhu J,Wu J,Liang Z,et al.Interactions between the breast tissue microbiota and host gene regulation in nonpuerperal mastitis[J]. Microbes and Infection,2022,24(3):104904.
[29] Hoque M N,Rahman M S,Islam T,et al.Induction of mastitis by cow-to-mouse fecal and milk microbiota transplantation causes microbiome dysbiosis and genomic functional perturbation in mice[J]. Animal Microbiome,2022,4(1):43.
[30] Scarselia E,Zecconi A,Cintio M,et al.Characterization of microbiome on feces,blood and milk in dairy cows with different milk leucocyte pattern[J]. Animals,2021,11(5):1463.
[31] Tenaillon O,Skurnik D,Picard B,et al.The population genetics of commensal Escherichia coli[J]. Nature Reviews Microbiology,2010,8(3):207-217.
[32] Zhong Z,Tang H,Shen T,et al.Bifidobacterium animalis subsp. lactis Probio-M8 undergoes host adaptive evolution by glcU mutation and translocates to the infant's gut via oral-/entero-mammary routes through lactation[J]. Microbiome,2022,10(1):197.
[33] Yung W,Hine B C,Wallace O A M,et al. Transfer of intestinal bacterial components to mammary secretions in the cow[J]. Peer J,2015,3:e888.
[34] Kuehn J S,Gorden P J,Munro D,et al.Bacterial community profiling of milk samples as a means to understand culture-negative bovine clinical mastitis[J]. PloS One,2013,8(4):e61959.
[35] Oikonomou G,Bicalho M L,Meira E,et al.Microbiota of cow's milk;distinguishing healthy,subclinically and clinically diseased quarters[J]. PloS One,2014,9(1):e85904.
[36] Zhang K,Chang G,Xu T,et al.Lipopolysaccharide derived from the digestive tract activates inflammatory gene expression and inhibits casein synthesis in the mammary glands of lactating dairy cows[J]. Oncotarget,2016,7(9):9652-9665.
[37] 陈志,张逸,路钦越,等. 茶树油对LPS诱导的奶牛乳腺炎的作用及其机制[J]. 中国农业科学,2021,54(14):3124-3133.

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