中国乳业 ›› 2025, Vol. 0 ›› Issue (1): 92-98.doi: 10.12377/1671-4393.25.01.15
粘靖祺, 赵臻*, 孙健, 王利*, 杨晓波
NIAN Jingqi, ZHAO Zhen*, SUN Jian, WANG Li*, YANG Xiaobo
摘要: 作为生命物质的基础,蛋白质在婴幼儿的生长发育中发挥着关键作用。母乳中含有的蛋白质具备多种生物学功能,然而当前婴幼儿配方奶粉在蛋白质组成方面与母乳仍存在明显的差异。本文对近年来的研究热点,如A2型β-酪蛋白、乳白蛋白、骨桥蛋白等对婴幼儿健康的影响,以及其在婴幼儿配方奶粉中的应用进展和未来发展趋势进行了详细的综述,旨在阐述深度母乳化活性蛋白组成和含量的婴幼儿配方奶粉设计开发的必要性和方法。
[1] 中国营养学会.中国居民膳食营养素参考摄入量(2023版)[M].北京:中国轻工业出版社,2023. [2] 荫士安. 人乳成分-存在形式、含量、功能、检测方法[M].北京:化学工业出版社,2016. [3] 顾瑞霞,骆承庠.乳与乳制品的生理功能特性[M].北京:中国轻工业出版社,2000. [4] 许亚君. 母乳营养与代谢[M].北京:北京大学医学出版社,2023. [5] 吴圣楣,蔡威.新生儿营养学[M].北京:人民卫生出版社,2016. [6] 张玉梅,石羽杰,张健,等.母乳α-乳清蛋白、β-酪蛋白与婴幼儿健康的研究进展[J].营养学报,2020,42(1):78-82. [7] Lei C,Wu X,Wang S,et al.Mechanism analysis of promoting calcium absorption and bone formation of peptides from different casein fractions[J].Food Bioscience, 2024, 58.DOI:10.1016/j.fbio.2024.103728. [8] 陈文亮,苏米亚,贾宏信,等.β-酪蛋白的功能特性及其在婴儿配方乳粉中的应用研究进展[J].乳业科学与技术,2020,43(2):38-43. [9] J.Sadler M,Smith N .β-酪蛋白与婴幼儿生长和发育[J].临床儿科杂志,2014,32(2):198-200. [10] Raikos V,Dassios T.Health-promoting properties of bioactive peptides derived from milk proteins in infant food: A review.[J].Dairy science & technology,2013,94(2):191-101. [11] Enjapoori A K, Kukuljan S, Dwyer K M,et al.In vivo endogenous proteolysis yielding beta-casein derived bioactive beta-casomorphin peptides in human breast milk for infant nutrition. Nutrition[J]. 2019,57:259-267. [12] 荫士安. 人乳成分-存在形式、含量、功能、检测方法(第二版)[M].北京:化学工业出版社,2021. [13] 王妍,陈雨春,王畅,等.乳清蛋白的功能特性及其在乳制品生产中的应用[J].食品安全导刊,2021(18):40-42. [14] Layman D K, Bo L, Fernstrom J D.Applications for α-lactalbumin in human nutrition[J].Nutrition Reviews, 2018(6):444-460. [15] Lönnerdal B,Lien E L.Nutritional and physiologic significance of alpha-lactalbumin in infants[J].Nutrition Reviews,2003, 61(9):295-305. [16] Lönnerdal B.Bioactive proteins in human milk: Health,nutrition, and implications forinfant formulas.[J].The Journal of Pediatrics,2016,173:S4-S9. [17] Kamau S M,Cheison S C,Chen W,et al.Alpha-lactalbumin: Its production technologies and bioactive peptides[J].Comprehensive Reviews in Food Science and Food Safety,2010, 9(2):197-212. [18] Steijns J M,Van Hooijdonk A C M.Occurrence,structure,biochemical properties and technological characteristics of lactoferrin.[J].British Journal of Nutrition, 2000, 84(S1):11-17. [19] Kanyshkova T G,Buneva V N,Nevinsky G A.Lactoferrin and Its biological functions[J].Biochemistry,2001, 66(1):1-7. [20] Séverin,Sindayikengera,Wenshui X.Milk biologically active components as nutraceuticals: Review[J].Critical Reviews in Food Science & Nutrition, 2005, 45(7-8):645-656. [21] 张捷,葛欣羽,谢渊,等.乳铁蛋白与婴儿早期免疫力构建[J].食品科技,2024,49(6):71-78. [22] 张彩霞,苏宜香,杨玉凤.乳铁蛋白与婴幼儿健康研究进展[J].中国儿童保健杂志,2016,24(4):377-380. [23] Oda H,Wakabayashi H,Yamauchi K,et al.Lactoferrin and bifidobacteria[J].Biometals,2014, 27(5):915-922. [24] Xiya Z,Xu Z,Teng X,et al.Comparative effects between oral lactoferrin and ferrous sulfate supplementation on iron-deficiency anemia: A comprehensive review and meta-analysis of clinical trials[J].Nutrients,2022,14(3):543-543. [25] Ke C, Lan Z, Hua L, et al.Iron metabolism in infants: infuence of bovine lactoferrin from iron-fortifed formula[J]. Nutrition, 2015, 31(2): 304-309. [26] Conneely, Orla M .Antiinflammatory activities of lactoferrin[J].Journal of the American College of Nutrition, 2001, 20(sup5):389S-395S. [27] 中国营养学会妇幼营养分会.乳铁蛋白婴幼儿健康效应专家共识[J].临床儿科杂志, 2018, 36(11):82-86. [28] 闫晓斌,高瑞雄,袁凯,等.乳铁蛋白功能及作用效果[J].食品工业,2024,45(9):223-229. [29] O'Regan A, Berman J S .Osteopontin: A key cytokine in cell-mediated and granulomatous inflammation[J].International Journal of Experimental Pathology, 2000, 81(6):373-390. [30] Wang K X, Denhardt D T .Osteopontin:Role in immune regulation and stress responses[J].Cytokine & Growth Factor Reviews, 2008, 19(5-6):333-345. [31] Zhao H, Chen Q, Alam A,et al.The role of osteopontin in the progression of solid organ tumour[J].Cell Death & Disease, 2018, 9(3):356. [32] Wang X K,Denhardt T D.Osteopontin:Role in immune regulation and stress responses[J].Cytokine and Growth Factor Reviews,2008,19(5):333-345. [33] 中国食品科学技术学会.乳源性骨桥蛋白的科学证据(2024年版)[J/OL].中国食品学报,1-6[2025-01-06].http://kns.cnki.net/kcms/detail/11.4528.TS.20241024.1633.006.html. [34] Liu L,Jiang R, Lnnerdal B.Assessment of bioactivities of the human milk lactoferrin-osteopontin complex in vitro[J].The Journal of Nutritional Biochemistry,2019, 69:10-18. [35] 刘兰. 乳铁蛋白与骨桥蛋白互作及其复合物的生物活性功能研究[D]. 杭州:浙江大学,2019. [36] Rittling S R, Chambers A F .Role of osteopontin in tumour progression[J].The British journal of cancer, 2004(10):90. [37] Nie C, Zhao Y, Wang X, et al.Structure, biological functions, separation,properties,and potential applications of milk fat globule membrane (MFGM): A review[J]. Nutrients,2024,16(5):587. [38] Fontecha J, Brink L, Wu S,et al.Sources,production, and clinical treatments of milk fat globule membrane for infant nutrition and well-being[J].Nutrients,2020,12(6):1607-1631. [39] Moukarzel S,Dyer R,Garcia C,et al.Milk fat globule membrane supplementation in formula-fed rat pups improves reflex development and may alter brain lipid composition[J].Scientific Reports, 2018:15277-15285. [40] Maria C,Annalisa G,Chiara C.The Immunological role of milk fat globule membrane[J].Nutrients,2022,14(21):4574-4574. [41] Erica K,Diana R,Joana O,et al.Improving human health with milk fat globule membrane, lactic acid bacteria, and bifidobacteria[J].Microorganisms,2021,9(2):341-341. [42] Li T,Gao J,Du M, et al.Milk fat globule membrane supplementation modulates the gut microbiota and attenuates metabolic endotoxemia in high-fat diet-fed mice[J].Journal of Functional Foods,2018:56-65. [43] 王煜林,吉日木图,何静.乳脂球膜中的营养成分在婴儿健康和发育中的作用[J].中国食品学报,2023,23(6):402-410. [44] 郭洪萍,石羽杰,刘彪,等.乳脂球膜蛋白的研究进展[J].中国食物与营养,2020,26(3):14-18. [45] Li H,Guan K, Liu M,et al.Identification and anti-oxidative potential of milk fat globule membrane (MFGM)-derived bioactive peptides released through in vitro gastrointestinal digestion[J].Bioorganic Chemistry, 2024, 145.DOI:10.1016/j.bioorg.2024.107232. [46] 刘铭,鲁杏茹,李笑,等.A1型和A2型β-酪蛋白分离纯化及其消化特性[J].中国食品学报,2024,24(11):107-117. [47] 陈龙,付王艳,方琼燕,等.牛乳中β-酪蛋白基因分型及β-酪啡肽-7的研究进展[J].中国乳品工业,2019,47(8):29-34. [48] Duarte-Vázquez Miguel,García-Ugalde Carlos,Villegas-Gutiérrez Laura,et al.Production of Cow's Milk Free from Beta-Casein A1 and Its Application in the Manufacturing of Specialized Foods for Early Infant Nutrition[J].Foods, 2017, 6(7):50. [49] Ying M,Yubo Z,Hongtian L, et al.Effectiveness of growing-up milk containing only A2 β-casein on digestive comfort in toddlers:A randomized controlled trial in China[J].Nutrients,2023,15(6):1313. [50] Sheng X Y,Mi W,Yuan Q B,et al.An A2 β-casein infant formula with high sn-2 palmitate and casein phosphopeptides supports adequate growth,improved stool consistency, and bone strength in healthy,term Chinese infants:A randomized,double-blind,controlled clinical trial[J].Frontiers in Nutrition,2024.DOI:10.3389/fnut.2024.1442584. [51] 张丽博,张乐,梁雨馨,等.乳中功能性蛋白质分离技术研究进展[J].乳业科学与技术,2022,45(3):44-50. [52] 中华人民共和国国家卫生和计划生育委员会,国家食品药品监督管理总局. GB1903.17-2016 食品安全国家标准食品营养强化剂乳铁蛋白[S]. [53] 中国营养保健食品协会.中国特殊食品常用原料与应用[M].北京:中国工商出版社,2024. [54] Nelly Z,Staudt A K,Gitte G, et al.Efficacy of an MFGM-enriched complementary food in diarrhea, anemia, and micronutrient status in infants.[J].Journal of Pediatric Gastroenterology and Nutrition,2011,53(5):561-568. |
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