中国乳业 ›› 2021, Vol. 0 ›› Issue (10): 55-60.doi: 10.12377/1671-4393.21.10.12

• 试验研究 • 上一篇    下一篇

不同剂量25羟基维生素D3对断奶前犊牛血液生化指标、抗氧化能力和免疫功能的影响

王丽华, 徐宏建, 张全宇, 张城瑞, 张永根*   

  1. 东北农业大学动物科学技术学院,黑龙江哈尔滨 150030
  • 出版日期:2021-10-25 发布日期:2021-12-03
  • 通讯作者: *张永根(1962-),男,黑龙江哈尔滨人,博士,教授,博士生导师,研究方向为反刍动物营养与饲料科学。
  • 作者简介:王丽华(1995-),女,内蒙古通辽人,硕士,研究方向为反刍动物营养与饲料科学;徐宏建(1994-),男,黑龙江哈尔滨人,博士,研究方向为反刍动物营养与饲料科学;张全宇(1997-),男,黑龙江哈尔滨人,硕士,研究方向为反刍动物营养与饲料科学;张城瑞(1997-),男,甘肃白银人,硕士,研究方向为反刍动物营养与饲料科学。

Effects of Different Doses of 25-hydroxyvitamin D3 on Blood Biochemical Indices,Antioxidant Capacity and Immune Function of Pre-weaning Calves

WANG Lihua, XU Hongjian, ZHANG Quanyu, ZHANG Chengrui, ZHANG Yonggen*   

  1. College of Animal Sciences and Technology,Northeast Agriculture University,Harbin Heilongjing 150030
  • Online:2021-10-25 Published:2021-12-03

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摘要： 为研究不同剂量25羟基维生素D3[25(OH)VD3]对断奶前犊牛血液水平、抗氧化能力和免疫功能的影响,选取18 头健康状况良好的新生荷斯坦犊牛,随机分成3 组,每组6 头进行为期56 天的饲养试验。分为对照组[不添加25(OH)VD3]、低剂量组[25(OH)VD3添加量6 000 IU/头·天]和高剂量组[25(OH)VD3添加量12 000 IU/头·天]。结果表明,与对照组相比,随着25(OH)VD3添加剂量增加,血浆生长激素、胰岛素样生长因子-1、过氧化氢酶、超氧化物歧化酶、总抗氧化能力以及免疫球蛋白G(IgG)含量显著增加(P<0.05),而丙二醛含量随剂量增加而存在降低趋势(P=0.079)。与对照组和低剂量组相比,高剂量组血浆免疫球蛋白A(IgA)含量有增加趋势(P=0.059)。综上所述,断奶前犊牛饲喂高剂量25(OH)VD3有利于促进体内生长激素和胰岛素样生长因子-1分泌,可提高犊牛抗氧化能力,增强免疫功能。

关键词: 犊牛, 25羟基维生素D3[25(OH)VD3], 抗氧化能力, 免疫功能

Abstract: To study the effects of 25-hydroxyvitamin D3 [25(OH)VD3] at different doses on blood level, antioxidant capacity and immune function of pre-weaning calves,18 healthy Holstein calves were randomly assigned to 3 groups with 6 calves in each group for 56 days. They were divided into control group [0 IU 25(OH)VD3 per calf per day], low-dose group [6 000 IU 25(OH)VD3 per calf per day] and high-dose group [12 000 IU 25(OH)VD3 per calf per day]. The results showed that compared with the control group, the contents of plasma growth hormone, insulin-like growth factor-1, catalase, superoxide dismutase,total antioxidant capacity and immunoglobulin G (IgG) were significantly increased (P<0.05) with the increasing dose of 25(OH)VD3. The content of malondialdehyde decreased with the dosage of 25(OH)VD3 increased (P=0.079). Compared with the control group and the low-dose group, the plasma immunoglobulin A (IgA) content in the high-dose group had an increasing trend (P=0.059). In conclusion,feeding high doses of 25(OH)VD3 to calves before weaning can promote the secretion of growth hormone and insulin-like growth factor-1,improve antioxidant capacity, and enhance immune function.

Key words: calf, 25-hydroxyvitamin D3, antioxidant capacity, immune function

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