中国乳业 ›› 2021, Vol. 0 ›› Issue (10): 61-66.doi: 10.12377/1671-4393.21.10.13

• 试验研究 • 上一篇    下一篇

黄芪多糖、银黄联用对新生犊牛免疫力及发病的影响

郭思凡, 曹杰*   

  1. 中国农业大学动物医学院,北京 100193
  • 出版日期:2021-10-25 发布日期:2021-12-03
  • 通讯作者: *曹杰(1979-),男,山东枣庄人,博士,副教授,研究方向为奶牛疾病防治。
  • 作者简介:郭思凡(1995-),女,河北怀来人,硕士,研究方向为奶牛疾病防治。

Effects of Astragalus Polysaccharide Combined with Yinhuang Soluble Powder on Immunity and Diseases in Neonatal Calves

GUO Sifan, CAO Jie*   

  1. College of Veterinary Medicine,China Agricultural University,Beijing 100193
  • Online:2021-10-25 Published:2021-12-03

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摘要： 选取健康新生荷斯坦母犊80 头,随机分为试验组和对照组(40 头/组),试验组给予黄芪多糖5 g、银黄3 g,连用7 天,对照组不给药。第7天时测定免疫指标并观察3 周内母犊腹泻、肺炎发病情况。结果表明,相比于对照组,试验组犊牛血清白细胞介素2(IL-2)浓度提高8.4％、肿瘤坏死因子(TNF-α)浓度降低13.7%;T细胞淋巴亚群分布改善,CD4/CD8值提高6.6%;试验组犊牛血清总蛋白(TP)、IgG浓度较对照组分别提高0.28 g/dL和0.24 mg/mL。犊牛疾病低风险牧场,用药7 天内试验组犊牛腹泻发生率显著降低15.0%(P<0.05);犊牛疾病高发牧场,8~21 天试验组犊牛发病率显著降低35.0%(P<0.05),肺炎发病率显著降低30.0%(P<0.05)。说明黄芪多糖、银黄联用可有效提高新生犊牛免疫力,降低腹泻及肺炎发生率。

关键词: 黄芪多糖, 银黄, 新生犊牛, 腹泻, 肺炎

Abstract: To determine the effects of astragalus polysaccharide(APS) combined with Yinhuang soluble powder on immunity and diseases of neonatal calves, 80 neonatal Holstein calves in good health were divided into 2 groups randomly(N=40). The calves in the experimental group were fed with 5 g APS powder and 3 g Yinhuang soluble powder for 7 consecutive days, while the control group was not given any medication. The immune-related indicators were measured at the 7th day and the incidence was observed within 3 weeks. Compared with control group, serum IL-2 concentration of calves in experimental groups increased 8.0% and TNF-α concentration decreased 16.0%. The distribution of T cell lymphocyte subsets improved, and the CD4/CD8 value increased 6.0%. Serum total protein and IgG increased 0.28 g/dL and 0.24 mg/ mL respectively. Incidence rate of calf diarrhea was significantly reduced 15.0% (P < 0.05) in low-risk farm within 7 days and 35.0% (P < 0.05) in high-risk farm within 8~21 d. For respiratory diseases,incidence and disease index were significantly reduced 30.0% (P < 0.05) in high-risk farm. APS combined with Yinhuang soluble powder can effectively improve the immunity of neonatal calves and reduce the incidence of respiratory diseases and diarrhea.

Key words: astragalus polysaccharide, yinhuang soluble powder, calves, diarrhea, respiratory diseases

[1] Osorio J S.Gut health,stress,and immunity in neonatal dairy calves; the host side of host-pathogen interactions[J]. Journal of Animal Science and Biotechnology,2020,11(1):49-63.
[2] Dong N,Li X,Xue C,et al.Astragalus polysaccharides alleviates LPS‐induced inflammation via the NF-κB/MAPK signaling pathway[J]. Journal of Cellular Physiology,2020,235(7-8):5525-5540.
[3] Zheng Y,Ren W,Zhang L,et al.A review of the pharmacological action of astragalus polysaccharide[J]. Frontiers in Pharmacology,2020,11:349
[4] Chen C Y,Qi L W,Li H J,et al.Simultaneous determination of iridoids,phenolic acids,flavonoids,and saponins in Flos Lonicerae and Flos Lonicerae Japonicae by HPLC‐DAD‐ELSD coupled with principal component analysis[J]. Journal of Separation Science,2007,30(18):3181-3192.
[5] 孙珍洁,陆春雪. CD8+T细胞抗衣原体感染研究进展[J]. 微生物学免疫学进展,2018,46(6):80-84.
[6] Svensson C,Liberg P.The effect of group size on health and growth rate of Swedish dairy calves housed in pens with automatic milk-feeders[J]. Preventive Veterinary Medicine,2006,73(1):43-53.
[7] Costa J H C,Keyserlingk M A G V,Weary D M. Invited review;Effects of group housing of dairy calves on behavior, cognition, performance,and health[J]. Journal of Dairy Science,2016,99(4):2453-2467.
[8] Liu Q Y,Yao Y M,Zhang S W,et al.Astragalus polysaccharides regulate T cell-mediated immunity via CD11c(high)CD45RB(low)DCs in vitro[J]. Journal of Ethnopharmacology,2011,136(3):457-464.
[9] Xu S W,Wusiman A,Liu Z G,et al.pH-responsive Astragalus polysaccharides-loaded poly(lactic- co -glycolic acid) nanoparticles and their in vitro immunogenicity[J]. International Journal of Biological Macromolecules,2019, 125:865-875.
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