中国乳业 ›› 2022, Vol. 0 ›› Issue (6): 101-105.doi: 10.12377/1671-4393.22.06.19

• 乳品加工 • 上一篇    

母乳中的硝酸盐和亚硝酸盐及对婴儿健康的研究

王树庆, 范维江, 姜薇薇   

  1. 山东商业职业技术学院,山东济南 250103
  • 出版日期:2022-06-25 发布日期:2022-07-06
  • 作者简介:王树庆(1965-),男,山东济南人,博士,教授,研究方向为发酵工程、食品质量与安全控制;范维江(1972-),男,山东泰安人,博士,副教授,研究方向为食品科学;姜薇薇(1983-),女,山东济南人,硕士,副教授,研究方向为发酵工程。

Nitrate and Nitrite in Breast milk and Research for Infant Health

WANG Shuqing, FAN Weijiang, JIANG Weiwei   

  1. Shandong Institute of Commerce and Technology,Jinan Shandong 250103
  • Online:2022-06-25 Published:2022-07-06

摘要: 母乳是婴儿最完美的食物,含有婴儿发育所需的所有蛋白质、脂质、碳水化合物、微量元素,同时含有亚硝酸盐、硝酸盐等无机物。与婴幼儿配方乳粉(简称“婴配粉”)相比,母乳中富含亚硝酸盐,特别是初乳中含有较高浓度的亚硝酸盐,其对新生儿的生长发育具有重要的生理功能。最近的数据表明,母乳中亚硝酸盐含量与婴配粉中亚硝酸盐含量之间的差异可能是造成母乳喂养婴儿与婴配粉喂养婴儿在某些健康方面差异的原因。本文综述了母乳中硝酸盐、亚硝酸盐及其对婴儿健康影响方面的研究成果,为人们重新认识硝酸盐、亚硝酸盐在母乳及婴配粉中的作用具有一定的指导意义。

关键词: 硝酸盐, 亚硝酸盐, 母乳, 婴儿配方乳粉, 蓝婴症

Abstract: Breast milk is nature's the most perfect food. It contains all the proteins,lipids,carbohydrates,trace elements required for infant development,as well as inorganic substances such as nitrite and nitrate. Comparison to infant formula,breast milk is rich in nitrite,especially colostrum,which has important physiological functions for the growth and development of newborns. Recent data showed that the difference between nitrite content in breast milk and infant formula may be the cause of some health differences between breast fed and formula fed infants. This paper reviewed the research results of nitrate and nitrite in breast milk and their effects on infant health,that provided some guidance for people to reunderstand the role of nitrate and nitrite in breast milk and infant formula.

Key words: nitrate, nitrite, breast milk, infants formula, blue-baby syndrome

中图分类号: 

  • O657.75
[1] 丁晓雯,柳春红.食品安全学[M].北京:中国农业出版社,2011.
[2] Binkerd E F,Kolari O E.The history and use of nitrate and nitrite in the curing of meat[J]. Food Cosmet Toxicol,1975,13:655-661.
[3] Tannenbaum S R,Fett D,Young V R,et al.Nitrite and nitrate are formed by endogenous synthesis in the human intestine[J]. Science,1978,200:1487-1488.
[4] Lundberg J O,Weitzberg E,Cole J A,et al.Nitrate,bacteria and human health[J]. Nature Reviews Microbiology,2004,2(7):593-602.
[5] Bryan N S,Loscalzo J.Nitrite and nitrate in human health and disease[M].New York:Humana Press,2011.
[6] Kevil C G,Kolluru G K,Pattillo C B,et al.Inorganic nitrite therapy:historical perspective and future directions[J]. Free Radical Biology and Medicine,2011,51:576-593.
[7] Gartner L M,Morton J,Lawrence R A,et al.Breastfeeding and the use of human milk[J].Pediatrics,2005,115(2):496-506.
[8] Greer F R. Shannon M.Infant methemoglobinemia:the role of dietary nitrate in food and water[J]. Pediatrics, 2005,116(3):784-786.
[9] G. M.McKnight,C. W. Duncan,C. Leifert,et al. Dietary nitrate in man:friend or foe?[J].British Journal of Nutrition,1999,81(5):349-358.
[10] Fan A M,Steinberg V E.Health implications of nitrate and nitrite in drinking water:an update on methemoglobinemia occurrence and reproductive and developmental toxicity[J]. Regulatory Toxicology and Pharmacology,1996,23(1):35-43.
[11] Power G G,Bragg S L,Oshiro B T,et al.A nobel method of measuring reduction of nitrite-induced methemoglobinapplied to fetal and adult blood of humans and sheep[J]. Journal of Applied Physiology,2007, 103:1359-1365.
[12] Kross B C,Ayebo A D,Fuortes L J.Methemoglobinemia:Nitrate toxicity in rural America[J]. American family physician,1992,46(1):183-188.
[13] Authority E F S. Nitrate in vegetables: scientific opinion of the panel on contaminants in the food chain[J]. EFSA Journal,2008,289:1-79.
[14] Johnson C J,Kross B C.Continuing importance of nitrate contamination of groundwater and wells in rural areas[J]. American Journal of Industrial Medicine,1990,18(4):449-456.
[15] Hord N G,Ghannam J S,Garg H K.,et al.Nitrate and nitrite content of human,formula,bovine,and soy milks:implications for dietary nitrite and nitrate recommendations[J]. Breastfeeding Medicine,2011, 6:393-399.
[16] Berens P D,Bryan N S.Nitrite and Nitrate in Human Health and Disease[M].Switzerland:Humana Press,2017.
[17] Dusdieker L B,Stumbo P J,Kross B C,et al.Does increased nitrate ingestion elevate nitrate levels in human milk?[J]. Archives of Pediatrics and Adolescent Medicine, 1996,150:311-314.
[18] Greer F R,Shannon M.Infant methemoglobinemia:the role of dietary nitrate in food and water[J]. Pediatrics, 2005,116:784-786.
[19] Neville M C.Physiology of lactation[J]. Clinics in Perinatology,1999,26(2):251-279.
[20] Ohta N,Tsukahara H,Ohshima Y,et al.Nitric oxide metabolites and adrenomedullin in human breast milk[J]. Early Human Development, 2004,78(1):61-65.
[21] Iizuka T,Sasaki M,Oishi K, et al.Non-enzymatic nitric oxide generation in the stomachs of breastfed neonates[J]. ACTA Paediatria, 1999,88(10):1053-1055.
[22] Cekmen M B,Balat A,Balat O,et al.Decreased adrenomedullin and total nitrite levels in breast milk of preeclamptic women[J]. Clinical Biochemistry, 2004,37(2):146-148.
[23] Heinig M J.The American Academy of Pediatrics recommendations on breastfeeding and the use of human milk[J]. Journal of Human Lactation,1998,14(1):2-3.
[24] Petersson J,Carlstrom M,Schreiber O,et al.Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash[J]. Free Radic Biology and Medicine, 2009,46(8):1068-1075.
[25] Ahdrew J,Webb,Nakul Patel,et al.Acute blood pressure lowering,vasoprotective,and antiplatelet properties of dietary nitrate via bioconversion to nitrite[J]. Hypertension,2008,51(3):784-90.
[26] Neu J,Walker WA.Necrotizing enterocolitis[J]. The New England Journal of Medicine, 2011,364(3):255-64.
[27] Dominguez K M,Moss R L.Necrotizing enterocolitis[J].Clinics Perinatology,2012,39(2):387-401.
[28] Gephart S M,McGrath J M,Effken J A,et al.Necrotizing enterocolitis risk[J]. Advance in Neonatal Care,2012,12(2):77-89.
[29] Yazji I,Sodhi C P,Lee E K,et al.Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling[J].Proceedings of the National Academy of Sciences,USA,2013,110(23):9451-9456.
[30] Fulhan J,Collier S,Duggan C.Update on pediatric nutrition:breastfeeding,infant nutrition,and growth[J].Current Opinion in Pediatrics,2003,15(3):323-32.
[31] Shu X O,Linet M S,Steinbuch M,et al.Breast-feeding and risk of childhood acute leukemia[J].Journal of the National Cancer Institute,1999,91(20):1765-1772.
[32] A Singhal.Early nutrition and long-term cardiovascular health[J].Nutrition Reviews, 2006,64(5):s44-s49.
[1] 杜玲玲. 母乳营养补充剂营养素的稳定性研究分析[J]. 中国乳业, 2022, 0(5): 69-74.
[2] 刘宝华, 徐庆利, 孙欣瑶, 杜玲玲, 巴宁宁. 婴儿配方乳粉营养素的稳定性研究[J]. 中国乳业, 2022, 0(3): 85-93.
[3] 崔承远. 婴幼儿配方乳粉中1,3-二油酸-2-棕榈酸甘油三酯的测量不确定度评估[J]. 中国乳业, 2022, 0(1): 63-68.
[4] 王炜宏, 杨新球. 低聚果糖与低聚半乳糖在婴幼儿配方乳粉中的精准化应用[J]. 中国乳业, 2021, 0(7): 102-108.
[5] 陈忱. 各阶段母乳中维生素A含量测定与比较[J]. 中国乳业, 2021, 0(5): 100-104.
[6] 宫春颖, 王青云, 粘靖祺, 王帅, 孙健. 婴幼儿配方食品中氨基酸模式的研究进展[J]. 中国乳业, 2020, 0(7): 59-63.
[7] 王青云, 赵臻, 粘靖祺. 黑龙江省哈尔滨地区母乳中脂肪酸的研究[J]. 中国乳业, 2020, 0(4): 88-91.
[8] 赵臻, 王丹, 王青云, 粘靖祺. 黑龙江省哈尔滨市母乳中矿物质含量的检测[J]. 中国乳业, 2020, 0(3): 71-73.
[9] 梁晨, 郑秀瑾, 金晓晓, 张锦梅, 张苗苗. 离子色谱两种检测器测定乳制品中亚硝酸盐和硝酸盐方法比较[J]. 中国乳业, 2020, 0(10): 53-57.
[10] 王青云, 王帅, 孙健. 人乳脂替代品在婴幼儿配方奶粉中的研究进展[J]. 中国乳业, 2019, 0(5): 65-70.
[11] 乌江雨. 几种常用植物油在婴儿配方乳粉中的应用[J]. 中国乳业, 2019, 0(3): 83-84.
[12] 戴逸, 莫红卫, 张岩春, 潘丽娜, 戴智勇, 刘成国, 周辉. 婴幼儿配方乳粉中油脂的组成及其微胶囊化研究进展[J]. 中国乳业, 2018, 0(1): 53-56.
[13] 刘翠平, 闫永恒, 范炜宇, 宝黎, 邱斌, 杜方玲, 陈亮, 徐同成. 不同时代因素、地域因素及经济条件对中国母乳脂肪酸构成的影响研究[J]. 中国乳业, 2018, 0(1): 66-73.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!