ω-3多不饱和脂肪酸富集型乳品生产的研究进展

doi:10.12377/1671-4393.24.12.21

中国乳业 ›› 2024, Vol. 0 ›› Issue (12): 117-123.doi: 10.12377/1671-4393.24.12.21

ω-3多不饱和脂肪酸富集型乳品生产的研究进展

王来娣^1,3, 姜庆林^1,3, 杨仁琴^2,3, 徐广新^2,3, 周炜^2,3, 张扬⁴, 常国斌^4,*

1 扬州大学实验农牧场,江苏扬州 225009;
2 江苏省乳业生物工程技术研究中心,江苏扬州 225004;
3 扬州市扬大康源乳业有限公司,江苏扬州 225004;
4 扬州大学动物科学与技术学院,江苏扬州 225009

出版日期:2024-12-25 发布日期:2025-01-03
通讯作者: ^*常国斌（1975-）,男,江苏泰兴人,博士,教授,研究方向为动物遗传育种与繁殖。
作者简介:王来娣（1987-）,女,江苏如皋人,博士,畜牧师,研究方向为动物脂代谢机制;姜庆林（1979-）,男,江苏扬州人,博士,高级畜牧师,研究方向为乳品加工;杨仁琴（1979-）,男,江苏扬州人,硕士,正高级工程师,研究方向为乳品研发;徐广新（1990-）,男,江苏扬州人,硕士,高级工程师,研究方向为乳品研发;周炜（1987-）,男,江苏扬州人,硕士,工程师,研究方向为乳品研发;张扬（1986-）,男,山东临沂人,博士,副教授,研究方向为动物遗传育种与繁殖。
基金资助:
扬州市科技计划项目——自然科学基金（YZ2023157）; 扬州市现代奶业科学与技术重点实验室项目(YZ2022161)

Research Progress of ω-3 Polyunsaturated Fatty Acid Enriched Dairy Production

WANG Laidi^1,3, JIANG Qinglin^1,3, YANG Renqin^2,3, XU Guangxin^2,3, ZHOU Wei^2,3, ZHANG Yang⁴, CHANG Guobin^4,*

¹Yangzhou University Experimental Farm, Yangzhou Jiangsu 225009;
²Jiangsu Dairy Biotechnology Research Center,Yangzhou Jiangsu 225004;
³Yangzhou Yangda Kangyuan Dairy Co.,Ltd., Yangzhou Jiangsu 225004;
⁴Yangzhou University College of Animal Science and Technology, Yangzhou Jiangsu 225009

Online:2024-12-25 Published:2025-01-03

摘要/Abstract

摘要： 乳中富含乳脂肪,是人类摄入脂肪酸的重要来源。研究表明,人类心血管疾病、癌症等的发生与摄入的脂肪酸组成密切相关。而乳中含有较高的饱和脂肪酸,ω-6/ω-3 多不饱和脂肪酸（PUFA）比值较高,脂肪酸组成并未达到最优,这也是乳品消费的争议所在。随着人们健康意识的提升,消费者更加注重脂肪酸的平衡营养。基于此,本文从全产业链的角度总结了在营养、遗传、基因工程以及生产加工工艺等方面进行ω-3 PUFA富集型乳品开发的相关成果,以期为后续研究提供参考依据。

关键词: 乳, ω-3多不饱和脂肪酸, 营养, 遗传, 生产工艺

Abstract: Milk is rich in milk fat,which is an important source of human intake of fatty acids. Studies have shown that the occurrence of cardiovascular diseases and cancers in humans is highly correlated with the composition of fatty acid consumed. While milk contains high saturated fatty acid and ω-6/ω-3 polyunsaturated fatty acid（PUFA）ratio,the fatty acid composition is not optimal,which is the controversy of dairy consumption. With the improvement of people's awareness of health,consumers pay more attention to the balanced nutrition of fatty acids. Based on this,this paper summarized the relevant achievements in the development of ω-3 PUFA enriched dairy products in the aspects of nutrition,genetics,genetic engineering and production and processing technology from the perspective of the whole industry chain,aiming to provide reference for subsequent research.

Key words: milk, ω-3 PUFA, nutrition, genetics, production technology

王来娣, 姜庆林, 杨仁琴, 徐广新, 周炜, 张扬, 常国斌. ω-3多不饱和脂肪酸富集型乳品生产的研究进展[J]. 中国乳业, 2024, 0(12): 117-123.

WANG Laidi, JIANG Qinglin, YANG Renqin, XU Guangxin, ZHOU Wei, ZHANG Yang, CHANG Guobin. Research Progress of ω-3 Polyunsaturated Fatty Acid Enriched Dairy Production[J]. China Dairy, 2024, 0(12): 117-123.

参考文献

[1] Pereira P C.Milk nutritional composition and its role in human health[J]. Nutrition, 2014, 30:619-627.
[2] Haug A,Høstmark A T,Harstad O M.Bovine milk in human nutrition--a review[J].Lipids in Health and Disease, 2007, 6:25.
[3] 邱冀,孟阳,赵怿,等.不同哺乳动物乳中主要营养成分研究进展[J]. 乳业科学与技术, 2021, 44:50-54.
[4] 李磊,王昆,何静,等.驼、牛、羊乳中脂肪酸含量的比较分析[J].食品科学, 2019, 40:223-227.
[5] Ness A R,Smith G D,Hart C.Milk,coronary heart disease and mortality[J].Journal of Epidemiology and Community Health, 2001, 55:379-382.
[6] Givens D I.Milk in the diet: good or bad for vascular disease?[J]. Proceedings of the Nutrition Society,2012,71:98-104.
[7] Moallem U.Invited review:Roles of dietary n-3 fatty acids in performance,milk fat composition,and reproductive and immune systems in dairy cattle[J].Journal of Dairy Science, 2018,101:8641-8661.
[8] Van Dael P.Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health:review of recent studies and recommendations[J].Nutrition Research and Practice,2021, 15:137-159.
[9] Watanabe Y,Tatsuno I.Prevention of Cardiovascular Events with Omega-3 Polyunsaturated Fatty Acids and the Mechanism Involved[J].Journal of Atherosclerosis and Thrombosis, 2020, 27:183-198.
[10] Hajri T,Abumrad N A.Fatty acid transport across membranes: relevance to nutrition and metabolic pathology[J].Annual Review of Nutrition,2002,22:383-415.
[11] 王来娣. 亚麻油调控鸭肝脏和胸肌多不饱和脂肪酸合成及代谢研究[D].扬州:扬州大学, 2022.
[12] Goyens P L,Spilker M E,Zock P L,et al.Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio[J]. American Journal of Clinical Nutrition, 2006,84:44-53.
[13] Schmitz G,Ecker J.The opposing effects of n-3 and n-6 fatty acids[J].Progress in Lipid Research,2008,47:147-155.
[14] Saini K,Keum Y S.Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources,metabolism,and significance - A review[J].Life Science,2018, 203:255-267.
[15] Li N,Jia M,Deng Q,et al.Effect of low-ratio n-6/n-3 PUFA on blood lipid level:a meta-analysis[J].Hormones (Athens), 2021,20:697-706.
[16] Abbott R D,Curb J D,Rodriguez B L,et al.Effect of dietary calcium and milk consumption on risk of thromboembolic stroke in older middle-aged men.The Honolulu Heart Program[J].Stroke,1996,27:813-818.
[17] Givens D I.Session 4: Challenges facing the food industry in innovating for health. Impact on CVD risk of modifying milk fat to decrease intake of SFA and increase intake of cis-MUFA[J].Proceedings of the Nutrition Society,2008,67:419-427.
[18] Noakes M,Nestel P J,Clifton P M.Modifying the fatty acid profile of dairy products through feedlot technology lowers plasma cholesterol of humans consuming the products[J]. American Journal of Clinical Nutrition,1996,63:42-46.
[19] Bjelková M,Nôžková J,Fatrcová-Šramková K,et al. Comparison of linseed (Linum usitatissimum L.) genotypes with respect to the content of polyunsaturated fatty acids[J]. Chemical Papers, 2012, 66:972-976.
[20] Jin F,Nieman D C,Sha W,et al.Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women[J].Plant Foods for Human Nutrition,2012,67:105-110.
[21] Bandarra N M,Marçalo A,Cordeiro A R,et al.Sardine (Sardina pilchardus) lipid composition:Does it change after one year in captivity?[J].Food Chemistry,2018,244:408-413.
[22] Monroig Ó,Tocher D R,Navarro J C.Biosynthesis of polyunsaturated fatty acids in marine invertebrates:recent advances in molecular mechanisms[J].Marine Drugs,2013, 11:3998-4018.
[23] Cholewski M,Tomczykowa M,Tomczyk M.A Comprehensive Review of Chemistry,Sources and Bioavailability of Omega-3 Fatty Acids[J].Nutrients,2018,10:1662.
[24] Kudrna V,Marounek M.Influence of feeding whole sunflower seed and extruded linseed on production of dairy cows,rumen and plasma constituents,and fatty acid composition of milk[J]. Archives of Animal Nutrition,2008,62:60-69.
[25] 刘瑞芳,嘎尔迪,苏利红,等.不同水平亚麻籽对奶牛产奶性能及乳中脂肪酸含量的影响[J].饲料工业,2018,39:29-33.
[26] Micek P,Kowalski Z M,Sady M,et al.An energy-protein feed additive containing different sources of fat improves feed intake and milk performance of dairy cows in mid-lactation[J]. Journal Of Dairy Research,2019,86:55-62.
[27] Bodkowski R C K,Sokoła-Wysoczańska E,Janczak M, etal. The effect of low-temperature crystallization of fish oil on the chemical composition,fatty acid profile,and functional properties of cow's milk[J].Animals (Basel), 2020,10:1834.
[28] Donovan D C,Schingoethe D J,Baer R J,et al.Influence of dietary fish oil on conjugated linoleic acid and other fatty acids in milk fat from lactating dairy cows[J].Journal of Dairy Science, 2000, 83:2620-2628.
[29] Kairenius P,Ärölä A,Leskinen H,et al.Dietary fish oil supplements depress milk fat yield and alter milk fatty acid composition in lactating cows fed grass silage-based diets[J]. Journal of Dairy Science,2015,98:5653-5671.
[30] Kupczyński R,Szołtysik M,Janeczek W,et al.Effect of dietary fish oil on milk yield,fatty acids content and serum metabolic profile in dairy cows[J].Journal of animal physiology and animal nutrition,2011,95:512-522.
[31] Abughazaleh AA,Potu R B,Ibrahim S.Short communication: The effect of substituting fish oil in dairy cow diets with docosahexaenoic acid-micro algae on milk composition and fatty acids profile[J]. Journal of Dairy Science,2009,92: 6156-6159.
[32] Glover K E,Budge S,Rose M,et al.Effect of feeding fresh forage and marine algae on the fatty acid composition and oxidation of milk and butter[J].Journal of Dairy Science, 2012, 95:2797-2809.
[33] Vahmani P,Fredeen A H,Glover K E.Effect of supplementation with fish oil or microalgae on fatty acid composition of milk from cows managed in confinement or pasture systems[J]. Journal of Dairy Science,2013,96:6660-6670.
[34] Shingfield K J,Bernard L,Leroux C,et al.Role of trans fatty acids in the nutritional regulation of mammary lipogenesis in ruminants[J]. Animal,2010,4:1140-1166.
[35] Ibeagha-Awemu E M,Akwanji K A,Beaudoin F,et al. Associations between variants of FADS genes and omega-3 and omega-6 milk fatty acids of Canadian Holstein cows[J]. BMC Genetics,2014,15:25.
[36] Castro L F,Tocher D R,Monroig O.Long-chain polyunsaturated fatty acid biosynthesis in chordates: Insights into the evolution of Fads and Elovl gene repertoire[J]. Progress in Lipid Research,2016,62:25-40.
[37] Xie D,Chen C,Dong Y,et al.Regulation of long-chain polyunsaturated fatty acid biosynthesis in teleost fish[J]. Progress in Lipid Research,2021,82:101095.
[38] Bastin C,Soyeurt H,Gengler N.Genetic parameters of milk production traits and fatty acid contents in milk for Holstein cows in parity 1-3[J].Journal Of Animal Breeding And Genetics,2013,130:118-127.
[39] Gillingham L G,Harding S V,Rideout T C,et al.Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition[J].American Journal Of Clinical Nutrition,2013,97:195-207.
[40] Schaeffer L,Gohlke H,Müller M,et al.Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids[J].Human Molecular Genetics, 2006, 15:1745-1756.
[41] Howard T D,Mathias R A,Seeds M,et al.DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver[J].PLoS One,2014,9:e97510.
[42] Merino D M,Johnston H,Clarke S,et al.Polymorphisms in FADS1 and FADS2 alter desaturase activity in young Caucasian and Asian adults[J].Molecular Genetics and Metabolism, 2011, 103:171-178.
[43] Illig T,Gieger C,Zhai G,et al.A genome-wide perspective of genetic variation in human metabolism[J].Nature Genetics, 2010,42:137-141.
[44] Watts J L,Browse J.Genetic dissection of polyunsaturated fatty acid synthesis in Caenorhabditis elegans[J].Proceedings of the National Academy of Sciences of the United States of America,2002,99:5854-5859.
[45] Spychalla J P,Kinney A J,Browse J.Identification of an animal omega-3 fatty acid desaturase by heterologous expression in Arabidopsis[J].Proceedings of the National Academy of Sciences of the United States of America,1997,94:1142-1147.
[46] Guo T,Liu X F,Ding X B,et al.Fat-1 transgenic cattle as a model to study the function of ω-3 fatty acids[J].Lipids in Health and Disease,2011,10:244.
[47] Wu X,Ouyang H,Duan B,et al.Production of cloned transgenic cow expressing omega-3 fatty acids[J].Transgenic Research,2012,21:537-543.
[48] Liu X,Bai C,Ding X,et al.Microarray Analysis of the Gene Expression Profile and Lipid Metabolism in Fat-1 Transgenic Cattle[J]. PLoS One,2015,10:e0138874.
[49] Liu X F,Wei Z Y,Bai C L,et al.Insights into the function of n-3 PUFAs in fat-1 transgenic cattle[J].Journal of Lipid Research,2017,58:1524-1535.
[50] Houdebine L M.Use of transgenic animals to improve human health and animal production[J].Reproduction in Domestic Animals,2005,40:269-281.
[51] 叶月丹. 不同热加工条件对牛羊乳脂肪酸的影响及差异性分析[D]. 陕西:西北农林科技大学, 2015.
[52] Dal Bello B,Torri L,Piochi M,et al.Healthy yogurt fortified with n-3 fatty acids from vegetable sources[J]. Journal of Dairy Science, 2015, 98:8375-8385.
[53] 李红艳. 多不饱和脂肪酸在婴儿配方奶粉中稳态化的研究[D]. 南昌:南昌大学, 2009.
[54] Raederstorff D,Wyss A,Calder P C,et al.Vitamin E function and requirements in relation to PUFA[J].British Journal of Nutrition, 2015, 114:1113-1122.

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ω-3多不饱和脂肪酸富集型乳品生产的研究进展

Research Progress of ω-3 Polyunsaturated Fatty Acid Enriched Dairy Production

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