乳及乳制品中高氯酸盐、氯酸盐的危害和原因分析

doi:10.12377/1671-4393.24.03.11

摘要/Abstract

摘要： 高氯酸盐和氯酸盐存在于许多食品中,包括生鲜乳和乳制品。高氯酸盐广泛存在于周围环境,特别是水生系统如地下水、饮用水、地表水、果汁、蔬菜以及乳制品。高氯酸盐可以通过多种途径进入人体,包括饮食和吸入。生鲜乳和乳制品中氯酸盐的存在可能是由于使用氯化水和食品加工级别的水和氯化洗涤剂清洗工艺设备。高氯酸盐和氯酸盐抑制人类的碘摄取和高铁血红蛋白的形成有关,婴儿和幼儿是高危人群。本文综述高氯酸盐和氯酸盐对人体的危害以及可能引起生鲜乳及乳制品中高氯酸盐和氯酸盐含量增高的原因。

关键词: 高氯酸盐, 氯酸盐, 食品安全, 生鲜乳, 乳制品

Abstract: Perchlorate and chlorate are ubiquitous pollutants in various types of foodstuffs, including milk and dairy products.widespread and large application of perchlorate has led to its ubiquitous occurrences in major environmental compartments, especially aquatic systems such as groundwater,drinking water , surface water , fruit juices,vegetables and dairy milks. perchlorate enters our bodies through various pathways, including diet and inhalation. The presence of chlorate in milk and dairy products can arise from the use of chlorinated water and chlorinated detergents for cleaning and sanitation of process equipment at both farm and food processor level.perchlorate and chlorate have been associated with inhibition of iodine uptake in humans and the formation of methemoglobin, with infants and young children being a high-risk demographic. This paper reviewed the hazards of perchlorates and chlorates to the human body, as well as the possible reasons for the increased content of perchlorates and chlorates in milk and dairy products.

Key words: perchlorate, chlorate, food safety, raw milk, dairy products

文静, 张志军, 古再丽努尔·艾麦提, 郭同军. 乳及乳制品中高氯酸盐、氯酸盐的危害和原因分析[J]. 中国乳业, 2024, 0(3): 57-64.

WEN Jing, ZHANG Zhijun, GU ZailiNuEr·Aimaiti, GUO Tongjun. Hazard and Cause Analysis of Perchlorate Chlorate in Milk and Dairy Products[J]. China Dairy, 2024, 0(3): 57-64.

参考文献

[1] Alomirah H F, Al-Zenki S F, Alaswad, et al.Widespread occurrence of perchlorate in water, foodstuffs and human urine collected from Kuwait and its contribution to human exposure[J]. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk, 2016, 33(6): 1016-1025.
[2] Maffini M V, Trasande L, Neltner T G,. Perchlorate and diet: human exposures, risks, and mitigation strategies[J].Current Environmental Health Reports, 2016, 3(2): 107-117.
[3] Agency for Toxic Substances and Disease Registry[M]. Toxicological profile for perchlorates,2008
[4] Bellanger M, Demeneix B, Grandjean P, et al.Response to the letter by middlebeek and veuger[J].Journal of Clinical Endocrinology & Metabolism, 2015, 100(6): L54-L55.
[5] Gil M I, Marín A, Andujar S, et al.Should chlorate residues be of concern in fresh-cut salads?[J].Food Control, 2016, 60: 416-421.
[6] Kettlitz B, Kemendi G, Thorgrimsson N, et al.Why chlorate occurs in potable water and processed foods: A critical assessment and challenges faced by the food industry[J].Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk, 2016, 33(6): 968-982.
[7] Marín A, Tudela J A, Garrido Y, et al.Chlorinated wash water and pH regulators affect chlorine gas emission and disinfection by-products[J]. Innovative Food Science & Emerging Technologies, 2020, 66:102533.
[8] Panseri S, Nobile M, Arioli F, et al.Occurrence of perchlorate, chlorate and polar herbicides in different baby food commodities[J].Food Chemistry, 2020b, 330:127205.
[9] Bo P, Lien J C, Chen Y Y, et al.Allyl isothiocyanate induces cell toxicity by multiple pathways in human breast cancer cells[J].American Journal of Chinese Medicine, 2016, 44(2): 415-437.
[10] Fu J, Lee W N, Coleman C, et al.Removal of disinfection byproduct (DBP) precursors in water by two-stage biofiltration treatment[J].Water Research, 2017, 123: 224-235.
[11] Lee E, Phua D H, Lim B L, et al.Severe chlorate poisoning successfully treated with methylene blue[J].Journal of Emergency Medicine, 2013, 44(2): 381-384.
[12] Ali S N, Ansari F A, Khan A A, et al.Sodium chlorate, a major water disinfection byproduct, alters brush border membrane enzymes, carbohydrate metabolism and impairs antioxidant system of wistar rat intestine[J].Environmental Toxicology, 2017, 32(5): 1607-1616.
[13] Panseri S, Arioli F, Biolatti C, et al.Detection of polyphosphates in seafood and its relevance toward food safety[J]. Food Chemistry, 2020a, 332: 127397.
[14] Tonacchera M, Pinchera A, Dimida A, et al.Relative potencies and additivity of perchlorate, thiocyanate, nitrate, and iodide on the inhibition of radioactive iodide uptake by the human sodium iodide symporter[J]. Thyroid, 2004, 14:1012-9.
[15] Vanderpas J, Bourdoux P, Lagasse R, et al.Endemic infantile hypothyroidism in a severe endemic goitre area of central Africa[J]. Clinical Endocrinology, 1984, 20: 327-40.
[16] Leung A M, Braverman L E, Pearce E N.History of iodine fortification and supplementation[J]. Nutrients, 2012, 4: 1740-6.
[17] American Thyroid Association, Iodine Deficiency[Z]. Accessed February 14, 2016. See Iodine Deficiency[Z]. Accessed February 14, 2016. See http://www.thyroid.org/iodine-deficiency/.
[18] Rose S R, Brown R S.Update of newborn screening and therapy for congenital hypothyroidism[J]. Pediatrics, 2006, 117(2):290-303.
[19] Dohan O, De La Vieja A, Paroder V, et al. The sodium/iodide symporter (NIS): characterization[J]. Endocrine Reviews, 2003, 24: 48-77.
[20] American Academy of Pediatrics Council on Environmental Health. Iodine deficiency, pollutant chemicals, and the thyroid: new information on an Old problem[J]. Pediatrics, 2014, 133: 1163-1165.
[21] Tonacchera M, Pinchera A, Dimida A, et al.Relative potencies and additivity of perchlorate, thiocyanate, nitrate, and iodide on the inhibition of radioactive iodide uptake by the human sodium iodide symporter[J]. Thyroid, 2004, 14:1012-9.
[22] World Health Organization.Assessment of iodine deficiency disorders and monitoring their elimination: A guide for programme managers[Z]. 2008.
[23] Caldwell K L, Pan Y, Mortensen M E, et al.Iodine status in pregnant women in the United States: national Children’s study and national health and nutrition examination survey[J]. Thyroid, 2013, 23:927-37.
[24] US Environmental Protection Agency Science Advisory Board. SAB advice on approaches to derive a maximum contaminant level goal for perchlorate[Z]. 2013.
[25] Pearce E N, Leung A M, Blount B C, et al.Breast milk iodine and perchlorate concentrations in lactating Boston-area women[J].Journal of Clinical Endocrinology &Metabolism,2007,92:1673-7.
[26] Schier J G, Wolkin A F, Valentin-Blasini L, et al.Perchlorate exposure from infant formula and comparisons with the perchlorate reference dose[J].Journal of Exposure Science and Environmental Epidemiology, 2010,20: 281-7.
[27] Kirk AB, Kroll M, Dyke JV, et al.Perchlorate, iodine supplements, iodized salt and breast milk iodine content[J].Science of the Total Environment, 2012, 420: 73-8.
[28] US Environmental Protection Agency Office of Water. Life stage considerations and interpretation of recent epidemiological evidence to develop a maximum contaminant level goal for perchlorate[Z]. 2012.
[29] Zhang T, Chen X, Wang D, et al.Perchlorate in indoor dust and human urine in China: contribution of indoor dust to total daily intake[J].Environmental Science & Technology 2015, 49: 2443-2450.
[30] Wan Y, Wu Q, Abualnaja K O, et al.Occurrence of perchlorate in indoor dust from the United States and eleven other countries: implications for human exposure[J]. Environment International, 2015, 75: 166-71.
[31] Blount B C, Valentin-Blasini L, Osterloh J, et al.Perchlorate exposure of the US population, 2001-2002[J].Journal of Exposure Science and Environmental Epidemiology, 2007, 14: 400-7.
[32] Centers for Disease Control and Prevention, National Biomonitoring Program. Perchlorate biomonitoring summary. 2013. Perchlorate biomonitoring summary. 2013[Z]. See http://www.cdc.gov/biomonitoring/Perchlorate_ BiomonitoringSummary.html. Accessed November 3, 2015
[33] Zhang T, Ma Y, Wang D, et al.Placental transfer of and infantile exposure to perchlorate[J]. Chemosphere, 2015, 144: 948-54.
[34] Valentin-Blasini L, Blount B C, Otero-Santos S, et al.Perchlorate exposure and dose estimates in infants[J].Environmental Science & Technology, 2011, 45: 4127-32.
[35] Minhui L, Minhua X, Qinru X, et al.Perchlorate and chlorate in breast milk, infant formulas, baby supplementary food and the implications for infant exposure[J].Environment International, 2022, 158: 106939
[36] Huber D R, Blount B C, Mage D T, et al.Estimating perchlorate exposure from food and tap water based on US biomonitoring and occurrence data[J]. Journal of Exposure Science and Environmental Epidemiology, 2011, 21: 395-407.
[37] National Academy of Sciences. National research council committee to assess the health implications of perchlorate ingestion[M]. Washington DC: The National Academies Press; 2005.
[38] Greer M A, Goodman G, Pleus R C, et al.Health effects assessment for environmental perchlorate contamination: the dose response for inhibition of thyroidal radioiodine uptake in humans[J]. Environ Health Perspect, 2002, 110: 927-937.
[39] Murray C W, Egan S K, Kim H, et al.US Food and Drug Administration’s total diet study: dietary intake of perchlorate and iodine[J].Journal of Exposure Science and Environmental Epidemiology, 2008, 18: 571-80.
[40] Dasgupta P K, Dyke J V, Kirk A B, et al.Perchlorate in the United States. Analysis of relative source contributions to the food chain[J]. Environmental Science & Technology, 2006, 40: 6608-6614.
[41] Hogue C.Rocket-fueled river[J].Chemical & Engineering News, 2003, 81: 37-46.
[42] Urbansky E T, Brown S K, Magnuson M L, et al.Perchlorate levels in samples of sodium nitrate fertilizer derived from Chilean caliche[J]Environmental Pollution,2001,112:299-302.
[43] EFSA Panel on Contaminants in the Food Chain (CONTAM). Risks for public health related to the presence of chlorate in food[J]. EFSA Journal,2015,13:(6):4135.
[44] FAO/WHO. Benefits and risks of the use of chlorine-containing disinfectants in food production and food processing: Report of a joint FAO/WHO Expert Meeting Ann Arbor, MI[Z], USA, 2009:27-30.
[45] Driedger A M,Rennecker J L,Marinas B J.Sequential inactivation of Cryptosporidium parvum oocysts with ozone and free chlorine[J]. Water Research,2000,34(14): 3591-3597.
[46] Richardson S D.Environmental mass spectrometry: Emerging contaminants and current issues[J]. Analytical Chemistry,2012,84(2):747-778.
[47] Bremer P J, Seale R B.Clean-in-Place(CIP). Encyclopedia of industrial biotechnology:bioprocess,bioseparation,and cell Technology[M].2009.
[48] Garcia-Villanova R J, Leite M V O D, Hierro J M H, et al. Occurrence of bromate, chlorite, and chlorate in drinking waters disinfected with hypochlorite reagents. Tracing their origins[J]. Science of the Total Environment,2010,408(12):2616-2620.
[49] Gordon G, Adam L,Bubnis B.Minimizing chlorate ion formation[J]. Journal-American Water Works Association, 1995,87(6):97-106.
[50] Bolyard M, Fair P S, Hautman D P.Occurrence of chlorate in hypochlorite solutions used for drinking water disinfection[J]. Environmental Science & Technology, 1992,26(8):1663-1665.
[51] Nieminski E C, Chaudhuri S, Lamoreaux T.The occurrence of DBPs in Utah drinking waters[J]. Journal-American Water Works Association,1993,85(9):98-105.
[52] AWWA Disinfection Systems Committee. Committee Report: Disinfection Survey, Part 1—Recent changes, current practices, and water quality[J]. Journal-American Water Works Association,2008,100(10): 76-90.
[53] William P McCarthy, Tom F O’Callaghan, Martin Danahar, et al. Christine O’Connor, Mark A. Fenelon, and John T.TobinChlorate and Other Oxychlorine Contaminants Within the Dairy Supply Chain[J]. Comprehensive Reviewsin Food Science and Food Safety,2018,17:1567-1575.
[54] Tamime A Y.Cleaning-in-place: Dairy, Food and Beverage Operations[M] 2009.
[55] Fischer W, Schilter B, Tritscher A, et al.Contaminants of milk and dairy products: Contamination resulting from farm and dairy practices[J]. Encyclopedia of Dairy Sciences,2011,2:887-897.
[56] McDonnell G, Russell A D. Antiseptics and disinfectants: activity, action, and resistance[J]. Clinical Microbiology Reviews, 1999,12(1):147-179.
[57] Gleeson D, O’Brien B. The effect of using nonchlorine products for cleaning and sanitising milking equipment on bacterial numbers and residues in milk[J]. International Journal of Dairy Technology,2013,66(2):182-188.
[58] Kaufmann-Horlacher I, Stroher-Kolberg D, Wildgrube C, Cerchia G.Chlorate residues in carrots traced to chlorinated water used in post-harvest treatment[Z]. 2014.

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