中国乳业 ›› 2025, Vol. 0 ›› Issue (6): 71-75.doi: 10.12377/1671-4393.25.06.12

• 疾病防治 • 上一篇    下一篇

绵羊乳腺免疫防御机制研究进展

刘来可1, 刘桂芹2   

  1. 1 阳谷县畜牧兽医事业发展中心, 山东阳谷 252300;
    2 聊城大学农学与农业工程学院, 山东聊城 252000
  • 出版日期:2025-06-25 发布日期:2025-07-04
  • 作者简介:刘来可（1983-）,男,山东阳谷人,本科,兽医师,研究方向为畜牧兽医技术;刘桂芹（1975-）,女,山东聊城人,博士,研究员,研究方向为微生物分子生物学及微生物免疫学。
  • 基金资助:
    聊城大学大学生创新创业训练计划资助项目（CXCY2023277）

Research Progress on Immune Defense Mechanism of Sheep Mammary Gland

LIU Laike1, LIU Guiqin2   

  1. 1 Yanggu County Animal Husbandry and Veterinary Business Development Center, Yanggu Shandong 252300;
    2 College of Agriculture and Agricultural Engineering, Liaocheng University, Liaocheng Shandong 252000
  • Online:2025-06-25 Published:2025-07-04

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摘要： 为了解绵羊乳腺免疫防御机制,本文介绍了参与乳腺免疫防御主要组织和免疫物质,包括乳房乳头、乳腺上皮细胞、白细胞、免疫球蛋白、补体系统和化学抗菌剂,描述它们之间的相互作用。乳头为乳腺提供最初保护。乳腺上皮细胞合成抗菌蛋白。白细胞产生各种炎症介质（细胞因子或趋化因子）,吞噬细菌并识别抗原结构。在乳腺中,4 种免疫球蛋白（IgG1、IgG2、IgM和IgA）对抵御病原体具有重要作用。补体系统是蛋白质集合,通过多种途径参与炎症过程。乳铁蛋白、溶菌酶和乳过氧化物酶等化学抗菌剂有助于乳腺体液防御。

关键词: 绵羊, 乳腺上皮细胞, 白细胞, 免疫球蛋白, 补体系统, 化学抗菌剂

Abstract: In order to clarify and understand the immune mechanism of sheep mammary gland,this paper introduces the main tissues and immune substances involved in the immune defense of mammary gland,including breast papilla,mammary epithelial cells,white blood cells,immunoglobulin,complement system and chemical antibacterial agents,and describes the cooperation and interaction between them.The nipple of the breast papilla provides the initial protection for the breast.Mammary epithelial cells synthesize antibacterial proteins and white blood cells produce various inflammatory mediators（cytokines or chemokines）,engulf bacteria and recognize antigenic structures.In the mammary gland,four immunoglobulins（IgG1,IgG2,IgM and IgA） play an important role in combating bacterial pathogens.The complement system is a collection of proteins that participate in the inflammatory process through a variety of ways.Chemical antibacterial agents such as lactoferrin,lysozyme and lactoperoxidase contribute to the defense of breast fluid.

Key words: sheep, mammary epithelial cell, white blood cell, immunoglobulin, complement system, chemical antibacterial agent

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