奶牛乳腺炎金黄色葡萄球菌毒力因子与抗菌素耐药性关系研究进展

doi:10.12377/1671-4393.25.07.15

摘要/Abstract

摘要： 金黄色葡萄球菌是奶牛乳腺炎的主要致病菌,其毒力因子与抗菌素耐药性对宿主健康和乳制品生产均产生重要影响。毒力因子如生物膜、肠毒素、溶血素等能够促进病原体在乳腺内的定殖和持久感染,而携带的抗菌耐药基因则进一步加剧治疗难度。随着分子生物学和基因组学技术的进步,金黄色葡萄球菌毒力因子与抗菌耐药机制的相互作用逐渐被揭示。本文总结近年来关于金黄色葡萄球菌毒力因子和抗菌耐药基因在奶牛乳腺炎中的研究进展,分析二者之间的协同性及其对感染过程的影响,探讨抗菌药物对病原体毒力与耐药性的调控作用,旨在为奶牛乳腺炎的精准防控及抗菌药物的合理使用提供理论支持。

关键词: 金黄色葡萄球菌, 毒力因子, 抗菌耐药性, 奶牛乳腺炎, 公共健康

Abstract: Staphylococcus aureus is the main pathogen causing mastitis in dairy cows. Its virulence factors and antibiotic resistance have significant impacts on host health and dairy product production. Virulence factors such as biofilms, enterotoxins, and hemolysins can promote the colonization and persistent infection of pathogens in the breast, while the antibacterial resistance genes carried further increase the difficulty of treatment. With the advancement of molecular biology and genomics techniques, the interaction between virulence factors of Staphylococcus aureus and the mechanism of antibacterial resistance has gradually been revealed. This paper summarizes the research progress in recent years on the virulence factors and antibacterial resistance genes of Staphylococcus aureus in bovine mastitis, analyzes the synergy between the two and their impact on the infection process, and explores the regulatory effect of antibacterial drugs on the virulence and drug resistance of pathogens, aiming to provide theoretical support for the precise prevention and control of bovine mastitis and the rational use of antibacterial drugs.

Key words: Staphylococcus aureus, virulence factor, antibiotic resistance, bovine mastitis, public health

伏广达, 刘维红, 胡智胜. 奶牛乳腺炎金黄色葡萄球菌毒力因子与抗菌素耐药性关系研究进展[J]. 中国乳业, 2025, 0(7): 90-99.

FU Guangda, LIU Weihong, HU Zhisheng. Research Progress on the Relationship Between Staphylococcus aureus Virulence Factors and Antibiotic Resistance in Bovine Mastitis[J]. China Dairy, 2025, 0(7): 90-99.

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