中国乳业 ›› 2025, Vol. 0 ›› Issue (8): 61-66.doi: 10.12377/1671-4393.25.08.10

• 疾病防治 • 上一篇    下一篇

科学使用抗炎药物提升犊牛福利与养殖效率的综述

王礞礞1, 李玉芳2, 杨旭3, 田园1, 王晶1,*   

  1. 1 中国农业科学院农业信息研究所,北京 100081;
    2 广饶县动物疫病预防控制中心,山东东营 257300;
    3 勃林格殷格翰动物保健(上海)有限公司,上海 200040
  • 出版日期:2025-08-25 发布日期:2025-09-10
  • 通讯作者: *王晶(1984-),女,内蒙古满洲里人,硕士,研究方向为畜牧养殖和奶业经济。
  • 作者简介:王礞礞(1982-),女,黑龙江哈尔滨人,博士,副研究员,研究方向为畜牧养殖和奶业经济;李玉芳(1974-),女,山东广饶人,本科,研究方向为畜牧兽医;杨旭(1988-),男,山东济南人,硕士,研究方向为兽医产科学;田园(1991-),女,北京人,硕士,助理研究员,研究方向为奶业产业。

Study on the Scientific Use of Anti-inflammatory Drugs to Improve Calf Welfare and Farming Efficiency

WANG Mengmeng1, LI Yufang2, YANG Xu3, TIAN Yuan1, WANG Jing1,*   

  1. 1 Agricultural Information Institute of CAAS,Beijing 100081;
    2 Guangrao County Animal Disease Prevention and Control Center,Dongying Shandong 257300;
    3 Boehringer Ingelheim Animal Health (Shanghai) Co.,Ltd.,Shanghai 200040
  • Online:2025-08-25 Published:2025-09-10

摘要: 在现代集约化奶牛养殖中,疾病防控与动物福利管理直接影响牧场经济效益。抗炎药物的科学应用不仅能有效缓解奶牛疼痛、控制炎症反应,还能显著改善动物福利并提高生产性能。本文结合国内外最新研究成果,以河北乐源家思牧业的实证数据为基础,探讨抗炎药物在犊牛去角中的关键作用。研究结果表明,去角后使用美洛昔康(一种高选择性COX-2抑制剂)可显著降低犊牛疼痛评分(降低30%以上),提高平均日增重10%~15%,并缩短创面愈合时间2~3 天。与传统非甾体抗炎药相比,美洛昔康具有胃肠道副作用小、药物残留低等优势,更适合犊牛使用。此外,本文提出了优化去角操作、强化饲养管理等配套措施,为牧场科学使用抗炎药物提供了系统化方案。研究证实,抗炎药物的规范化应用可同时实现动物福利与经济效益的双重提升,对推动我国奶牛养殖业高质量发展具有重要意义。

关键词: 抗炎药物, 犊牛去角, 动物福利, 美洛昔康, 养殖效率

Abstract: In modern intensive dairy farming,disease prevention and animal welfare management directly impact farm profitability. The rational use of anti-inflammatory drugs can effectively alleviate pain,control inflammatory responses,and significantly improve animal welfare and production performance. This study integrated the latest domestic and international research findings,supported by empirical data from Hebei Leyuan Jiasi Farm,to explore the critical role of anti-inflammatory drugs in calf dehorning. The results demonstrated that administering meloxicam (a highly selective COX-2 inhibitor) post-dehorning significantly reduces pain scores (by over 30%),increases average daily weight gain by 10%~15%,and shortens wound healing time by 2~3 days. Compared to traditional non-steroidal anti-inflammatory drugs(NSAIDs),meloxicam exhibits advantages such as fewer gastrointestinal side effects and lower drug residues,making it more suitable for calves. Additionally,this study proposed optimized dehorning techniques and improved feeding management practices,providing a systematic approach for the scientific use of anti-inflammatory drugs on farms. The research confirms that standardized application of anti-inflammatory drugs can simultaneously enhance animal welfare and economic benefits,offering significant implications for advancing high-quality development in China's dairy farming industry.

Key words: anti-inflammatory drugs, calf dehorning, animal welfare, meloxicam, farming efficiency

[1] WHO.Interspersion and Learning of Antimicrobial Resistance:Global Report on Surveillance 2014[R].Geneva:World Health Organization,2014.
[2] 孙康泰,张建民,蒋大伟,等.我国动物源细菌耐药性的研究进展及防控策略[J].中国农业科技导报,2020,22(5):1-5.
[3] 李志强. 美洛昔康对犊牛去角术后抗炎镇痛和血清抗氧化指标的影响[D].雅安:四川农业大学, 2021.
[4] Stafford K J, Mellor D J.Addressing the pain associated with disbudding and dehorning in cattle[J].Applied Animal Behaviour Science,2011,135(3):226-231.
[5] 白井岩,杨旭,张志宏.去角镇痛对犊牛断奶日增重的影响[J].中国乳业,2024(12):47-50.
[6] 屈阳,崔璐莹,王亨,等.非甾体类抗炎药在奶牛产后疾病中的应用[J].畜牧与兽医,2021,53(7):122-126.
[7] Barrier A C,Coombs T M,Dwyer C M,etal. Administration of a NSAID (meloxicam) affects lying behaviour after caesarean section in beef cows[J].Applied Animal Behaviour Science,2014,155:28-33.
[8] Stock M L,Coetzee J F.Clinical pharmacology of analgesic drugs in cattle[J].Veterinary Clinics of North America:Food Animal Practice,2015,31(1):113-138.
[9] 寇明明,刘玉辉,刘婧,等. 奶牛乳腺炎治疗研究进展[J].动物医学进展,2015,36(6):126-129.
[10] Caldeira M O,Bruckmaier R M,Wellnitz O.Meloxicam affects the inflammatory responses of bovine mammary epithelial cells[J].Journal of Dairy Research,2019,102(11):10277-10290.
[11] Lomb J,Neave H W,Weary D M,etal.Changes in feeding, social, and lying behaviors in dairy cows with metritis following treatment with a nonsteroidal anti-inflammatory drug as adjunctive treatment to an antimicrobial[J].Journal of Dairy Science,2018,101(5):4400-4411.
[12] Hewson C J,Dohoo I R,Lemke K A,etal.Canadian veterinarians' use of analgesics in cattle, pigs, and horses in 2004 and 2005[J]. Canadian Veterinary Journal,2007,48(2):155-164.
[13] Thiry J,Fournier R,Roy O,etal.Evaluation of flunixin meglumine pour-on administration on prostaglandin E2 concentration in inflammatory exudate after induction of inflammation in cattle[J].Research in Veterinary Science,2017,114:294-296.
[14] Shwartz G,Hill K L,VanBaale M J,etal.Effects of flunixin meglumine on pyrexia and bioenergetic variables in postparturient dairy cows[J].Journal of Dairy Science,2009,92(5):1963-1970.
[15] Richards B D,Black D H,Christley R M,etal. Effects of the administration of ketoprofen at parturition on the milk yield and fertility of Holstein-Friesian cattle[J].Veterinary Record,2009,165(4):102-106.
[16] Shpigel N Y,Chen R,Winkler M,etal. Anti-inflammatory ketoprofen in the treatment of field cases of bovine mastitis[J].Research in Veterinary Science,1994, 56(1):62-68.
[17] 贾兴,黄凯,耿智霞,等.卡洛芬注射液在奶牛体内的残留消除研究[J].中国兽药杂志,2025,59(2):43-49.
[18] Yang Y J,Liu X W,Kong X J,etal. An LC-MS/MS method for the quantification of diclofenac sodium in dairy cow plasma and its application in pharmacokinetics studies[J].Biomedical Chromatography,2019,33(7):e4520.
[19] 马应虎,朱飞飞,祁金忠,等.非甾体抗炎药双氯芬酸钠对奶牛胎衣不下的作用效果研究[J].中国奶牛,2025(6):17-22.
[20] Heinrich A,Duffield T F,Lissemore K D,etal.The effect of meloxicam on behavior and pain sensitivity of dairy calves following cautery dehorning with a local anesthetic[J].Journal of Dairy Science,2010,93(6):2450-2457.
[21] Stock M L,Baldridge S L,Griffin D,etal.Bovine dehorning:assessing pain and providing analgesic management[J].Veterinary Clinics of North America:Food Animal Practice,2013,29(1):103-133.
[22] Heinrich A,Duffield T F,Lissemore K D,etal.The impact of meloxicam on postsurgical stress associated with cautery dehorning[J].Journal of Dairy Science,2009,92(2):540-547.
[23] Faulkner P M,Weary D M.Reducing pain after dehorning in dairy calves[J].Journal of Dairy Science,2000,83(9):2037-2041.
[24] Bindu S,Mazumder S,Bandyopadhyay U.Non-steroidal anti-inflammatory drugs (NSAIDs)and organ damage:A current perspective[J].Biochemical Pharmacology,2020,180:114147.
[25] Miyashita M.Metacam Technical Manual[M].Ingelheim:Boehringer Ingelheim, 2005.
[26] Li X,Xu C,Liang B,etal.Alternatives to antibiotics for treatment of mastitis in dairy cows[J].Frontiers in Veterinary Science,2023,10:1160350.
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