中国乳业 ›› 2025, Vol. 0 ›› Issue (8): 61-66.doi: 10.12377/1671-4393.25.08.10
王礞礞1, 李玉芳2, 杨旭3, 田园1, 王晶1,*
WANG Mengmeng1, LI Yufang2, YANG Xu3, TIAN Yuan1, WANG Jing1,*
摘要: 在现代集约化奶牛养殖中,疾病防控与动物福利管理直接影响牧场经济效益。抗炎药物的科学应用不仅能有效缓解奶牛疼痛、控制炎症反应,还能显著改善动物福利并提高生产性能。本文结合国内外最新研究成果,以河北乐源家思牧业的实证数据为基础,探讨抗炎药物在犊牛去角中的关键作用。研究结果表明,去角后使用美洛昔康(一种高选择性COX-2抑制剂)可显著降低犊牛疼痛评分(降低30%以上),提高平均日增重10%~15%,并缩短创面愈合时间2~3 天。与传统非甾体抗炎药相比,美洛昔康具有胃肠道副作用小、药物残留低等优势,更适合犊牛使用。此外,本文提出了优化去角操作、强化饲养管理等配套措施,为牧场科学使用抗炎药物提供了系统化方案。研究证实,抗炎药物的规范化应用可同时实现动物福利与经济效益的双重提升,对推动我国奶牛养殖业高质量发展具有重要意义。
| [1] WHO.Interspersion and Learning of Antimicrobial Resistance:Global Report on Surveillance 2014[R].Geneva:World Health Organization,2014. [2] 孙康泰,张建民,蒋大伟,等.我国动物源细菌耐药性的研究进展及防控策略[J].中国农业科技导报,2020,22(5):1-5. [3] 李志强. 美洛昔康对犊牛去角术后抗炎镇痛和血清抗氧化指标的影响[D].雅安:四川农业大学, 2021. [4] Stafford K J, Mellor D J.Addressing the pain associated with disbudding and dehorning in cattle[J].Applied Animal Behaviour Science,2011,135(3):226-231. [5] 白井岩,杨旭,张志宏.去角镇痛对犊牛断奶日增重的影响[J].中国乳业,2024(12):47-50. [6] 屈阳,崔璐莹,王亨,等.非甾体类抗炎药在奶牛产后疾病中的应用[J].畜牧与兽医,2021,53(7):122-126. [7] Barrier A C,Coombs T M,Dwyer C M,etal. Administration of a NSAID (meloxicam) affects lying behaviour after caesarean section in beef cows[J].Applied Animal Behaviour Science,2014,155:28-33. [8] Stock M L,Coetzee J F.Clinical pharmacology of analgesic drugs in cattle[J].Veterinary Clinics of North America:Food Animal Practice,2015,31(1):113-138. [9] 寇明明,刘玉辉,刘婧,等. 奶牛乳腺炎治疗研究进展[J].动物医学进展,2015,36(6):126-129. [10] Caldeira M O,Bruckmaier R M,Wellnitz O.Meloxicam affects the inflammatory responses of bovine mammary epithelial cells[J].Journal of Dairy Research,2019,102(11):10277-10290. [11] Lomb J,Neave H W,Weary D M,etal.Changes in feeding, social, and lying behaviors in dairy cows with metritis following treatment with a nonsteroidal anti-inflammatory drug as adjunctive treatment to an antimicrobial[J].Journal of Dairy Science,2018,101(5):4400-4411. [12] Hewson C J,Dohoo I R,Lemke K A,etal.Canadian veterinarians' use of analgesics in cattle, pigs, and horses in 2004 and 2005[J]. Canadian Veterinary Journal,2007,48(2):155-164. [13] Thiry J,Fournier R,Roy O,etal.Evaluation of flunixin meglumine pour-on administration on prostaglandin E2 concentration in inflammatory exudate after induction of inflammation in cattle[J].Research in Veterinary Science,2017,114:294-296. [14] Shwartz G,Hill K L,VanBaale M J,etal.Effects of flunixin meglumine on pyrexia and bioenergetic variables in postparturient dairy cows[J].Journal of Dairy Science,2009,92(5):1963-1970. [15] Richards B D,Black D H,Christley R M,etal. Effects of the administration of ketoprofen at parturition on the milk yield and fertility of Holstein-Friesian cattle[J].Veterinary Record,2009,165(4):102-106. [16] Shpigel N Y,Chen R,Winkler M,etal. Anti-inflammatory ketoprofen in the treatment of field cases of bovine mastitis[J].Research in Veterinary Science,1994, 56(1):62-68. [17] 贾兴,黄凯,耿智霞,等.卡洛芬注射液在奶牛体内的残留消除研究[J].中国兽药杂志,2025,59(2):43-49. [18] Yang Y J,Liu X W,Kong X J,etal. An LC-MS/MS method for the quantification of diclofenac sodium in dairy cow plasma and its application in pharmacokinetics studies[J].Biomedical Chromatography,2019,33(7):e4520. [19] 马应虎,朱飞飞,祁金忠,等.非甾体抗炎药双氯芬酸钠对奶牛胎衣不下的作用效果研究[J].中国奶牛,2025(6):17-22. [20] Heinrich A,Duffield T F,Lissemore K D,etal.The effect of meloxicam on behavior and pain sensitivity of dairy calves following cautery dehorning with a local anesthetic[J].Journal of Dairy Science,2010,93(6):2450-2457. [21] Stock M L,Baldridge S L,Griffin D,etal.Bovine dehorning:assessing pain and providing analgesic management[J].Veterinary Clinics of North America:Food Animal Practice,2013,29(1):103-133. [22] Heinrich A,Duffield T F,Lissemore K D,etal.The impact of meloxicam on postsurgical stress associated with cautery dehorning[J].Journal of Dairy Science,2009,92(2):540-547. [23] Faulkner P M,Weary D M.Reducing pain after dehorning in dairy calves[J].Journal of Dairy Science,2000,83(9):2037-2041. [24] Bindu S,Mazumder S,Bandyopadhyay U.Non-steroidal anti-inflammatory drugs (NSAIDs)and organ damage:A current perspective[J].Biochemical Pharmacology,2020,180:114147. [25] Miyashita M.Metacam Technical Manual[M].Ingelheim:Boehringer Ingelheim, 2005. [26] Li X,Xu C,Liang B,etal.Alternatives to antibiotics for treatment of mastitis in dairy cows[J].Frontiers in Veterinary Science,2023,10:1160350. |
| [1] | 李潘潘, 王昌雷, 李兴栋, 杨萍, 刘玉升, 陶家树. 人工智能与传感器技术在奶牛养殖业中的应用与挑战[J]. 中国乳业, 2025, 0(6): 59-66. |
| [2] | 白井岩, 杨旭, 张志宏. 去角镇痛对犊牛断奶日增重的影响[J]. 中国乳业, 2024, 0(12): 47-50. |
| [3] | 袁思桡, 方思成, 郭勇庆, 柳广斌. 智慧养殖技术在奶山羊生产中的应用研究进展[J]. 中国乳业, 2024, 0(11): 15-21. |
|
||