金黄色葡萄球菌引起牛乳腺炎的抗微生物应对措施

doi:10.12377/1671-4393.25.08.11

摘要/Abstract

摘要： 乳腺炎是全球范围内影响奶牛的常见疾病,主要由金黄色葡萄球菌引起,通常依赖乳腺内注射和肌肉注射抗微生物药物治疗,但随着抗微生物耐药性的上升,治疗面临更大挑战且可选方案逐渐减少。生物膜的形成、致病菌在乳腺上皮细胞中的附着,使治疗更复杂。本文综述抗微生物耐药性增加、生物膜形成和细菌在细胞内存活等因素,分析常规抗生素治疗乳腺炎的挑战。同时,介绍植物化学化合物、抗微生物肽、噬菌体治疗及基于石墨烯纳米材料的替代治疗方法,这些方法有望弥补现有抗微生物药物治疗的不足,缓解抗微生物耐药性对乳腺炎治疗的威胁。本文旨在探讨乳腺炎治疗中的新兴替代方案,以期为未来的临床治疗提供有力支持。

关键词: 乳腺炎, 治疗, 金黄色葡萄球菌, 抗微生物, 替代治疗

Abstract: Mastitis is a common disease affecting dairy cows globally,primarily caused by Staphylococcus aureus,and is typically treated with antimicrobial drugs administered via intramammary and intramuscular injections.However,with the increasing rise of antimicrobial resistance,the treatment faces greater challenges and the available therapeutic options are gradually diminishing.The formation of biofilms formation and the adhesion of pathogens to mammary epithelial cells complicate treatment further.This paper discusseed factors such as the rise in antimicrobial resistance,biofilm formation,and intracellular bacterial survival,analyzing the challenges of conventional antibiotic treatment for mastitis.Additionally,it introduces alternative therapeutic approaches,including phytochemicals,antimicrobial peptides,bacteriophage therapy,and graphene-based nanomaterials,which may address the shortcomings of current antimicrobial treatments and mitigate the threat of antimicrobial resistance to mastitis treatment.This paper aimed to explore emerging alternative approaches in the treatment of mastitis,with the goal of providing robust support for future clinical therapies.

Key words: mastitis, treatment, Staphylococcus aureus, antimicrobial, alternative therapy

严海涛, 纪双慧, 胡智胜. 金黄色葡萄球菌引起牛乳腺炎的抗微生物应对措施[J]. 中国乳业, 2025, 0(8): 67-74.

YAN Haitao, JI Shuanghui, HU Zhisheng. The Antimicrobial Strategies against Staphylococcus aureus-induced Bovine Mastitis[J]. China Dairy, 2025, 0(8): 67-74.

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