中国乳业 ›› 2025, Vol. 0 ›› Issue (11): 82-91.doi: 10.12377/1671-4393.25.11.10
卓依娜1,2, 郑楠1, 赵艳坤1,3, 孟璐1,*
ZHUO Yina1,2, ZHENG Nan1, ZHAO Yankun1,3, MENG Lu1,*
摘要: 马奶是一种营养成分与人体母乳高度相似的天然乳制品,因其低致敏性、高消化率及丰富的生物活性物质而备受关注。本文系统综述了马的泌乳规律、马奶的基础营养成分(蛋白质、脂肪、乳糖、矿物质与维生素)、活性成分[如乳铁蛋白、溶菌酶、乳脂球膜(MFGM)蛋白等]及其功能特性。研究表明,马奶的酪蛋白与乳清蛋白比例接近人乳,致敏性低;其乳脂球膜(MFGM)中鉴定出773 种功能蛋白,与免疫调节、细胞代谢密切相关。发酵工艺可显著提升马奶营养价值,酸马奶中乳糖含量降低,并产生抗菌肽、有机酸等代谢产物,赋予其调节血脂、增强免疫等功能。本文还探讨了酸马奶、马奶粉等衍生产品的开发潜力,未来应加强马奶活性成分的作用机制解析,优化标准化生产与加工技术,推动其从区域性民族食品向高值化功能性食品产业发展,为中国特色乳业资源开发提供支撑。
| [1] 韩国才. 马的起源驯化、种质资源与产业模式[J].生物学通报,2014,49(2):1-3,63. [2] 敖敏,赵一萍,康德措,等.马奶营养价值和产品开发进展[J].内蒙古科技与经济,2018(20):63-65. [3] Liu X,Jia Y,Pan J,et al.Selection at the GSDMC locus in horses and its implications for human mobility[J].Science,2025,389(6763):925-930. [4] Blanco-Doval A,Barron L J R,Aldai N.Nutritional quality and socio-ecological benefits of mare milk produced under grazing management[J].Foods,2024,13(9):1412. [5] Xia Y,Yu J,Miao W,et al.A UPLC-Q-TOF-MS-based metabolomics approach for the evaluation of fermented mare's milk to koumiss[J].Food Chemistry,2020,320:126619. [6] 张萌萌,赵雪妮,双全,等.马奶营养品质及功能特性的发酵动态分析[J].食品与发酵工业,2022,48(7):103-109. [7] 陶克涛,芒来.马奶酒与马奶粉营养成分分析研究[J].黑龙江畜牧兽医,2015(21):107-109,113. [8] Centoducati P,Maggiolino A,De Palo P,et al.Application of Wood's model to lactation curve of Italian Heavy Draft horse mares[J].Journal of Dairy Science,2012,95(10):5770-5775. [9] Lancioni H,Cardinali I,Giontella A,et al.Mitochondrial DNA variation in the Italian Heavy Draught Horse[J].PeerJ, Inc,2020,8:e8996. [10] 孙啸渊,薛利,古丽巴合提·达吾列提汗,等.哈萨克马泌乳拟合及乳中营养成分分析[J].黑龙江畜牧兽医,2025(3):47-53. [11] 吕士鹏,刘玲玲,孟军,等.伊犁马泌乳曲线的拟合研究[J].中国畜牧杂志,2019,55(4):66-69. [12] Malacarne M,Martuzzi F,Summer A,et al.Protein and fat composition of mare's milk:some nutritional remarks with reference to human and cow's milk[J].International Dairy Journal,2002,12(11):869-877. [13] 莫合塔尔·夏甫开提.新疆乳用型马品种有关的前期研究进展[J].新疆畜牧业,2016(6):27-29. [14] 蔡俊娜. 羊乳蛋白体外模拟消化及羊乳对肠道微生物的影响[D].西安:陕西师范大学,2021. [15] Teichert J,Cais-Sokolińska D,Danków R,et al.Color stability of fermented mare’s milk and a fermented beverage from cow’s milk adapted to mare’s milk composition[J].Foods,2020,9(2):217. [16] 张志恒,范文鹏,黄越川,等.不同品种牛牛嘴宽度与生产性状的相关分析[J].中国畜牧杂志,2023,59(11):129-132. [17] Musaev A,Sadykova S,Anambayeva A,et al.Mare’s milk:composition,properties,and application in medicine[J].Archives of Razi Institute,2021,76(4):1125-1135. [18] Kushugulova A,Kozhakmetov S,Sattybayeva R,et al.Mare's milk as a prospective functional product[J].Functional Foods in Health and Disease,2018,8(11):548-554. [19] Kocyigit E,Abdurakhmanov R,Kocyigit B F.Potential role of camel,mare milk,and their products in inflammatory rheumatic diseases[J].Rheumatology International,2024,44(3):425-434. [20] Liu C,Liu L-X,Yang J,et al.Exploration and analysis of the composition and mechanism of efficacy of camel milk[J].Food Bioscience,2023,53:102564. [21] 李龙柱,张富新,贾润芳,等.不同哺乳动物乳中主要营养成分比较的研究进展[J].食品工业科技,2012,33(19):396-400. [22] Businco L,Giampietro P G,Lucenti P,et al.Allergenicity of mare’s milk in children with cow’s milk allergy[J].ournal of Allergy and Clinical Immunology,2000,105(5):1031-1034. [23] 邱冀,孟阳,赵怿,等.不同哺乳动物乳中主要营养成分研究进展[J].乳业科学与技术,2021,44(3):50-54. [24] 张妍. 不同哺乳期山羊乳脂质组成及其消化吸收特性的比较研究[D].无锡:江南大学,2021. [25] 吴宝森,孙玥晖,刘姝韵,等.发酵肉制品中脂肪、蛋白质水解氧化与微生物的关系[J].食品安全质量检测学报,2017,8(3):832-837. [26] Potočnik K,Gantner V,Kuterovac K,et al.Mare’s milk:composition and protein fraction in comparison with different milk species[J].Mljekarstvo:časopis za unaprjeđenje proizvodnje i prerade mlijeka,2011,61(2):107-113. [27] 鲍台山. 双峰驼乳对Ⅱ型糖尿病模型大鼠红细胞膜抗氧化作用的初探[D].呼和浩特:内蒙古农业大学,2015. [28] Kocyigit E,Abdurakhmanov R,Kocyigit B F.Potential role of camel,mare milk,and their products in inflammatory rheumatic diseases[J].Rheumatology International,2024,44(3):425-434. [29] 唐鲲. 1.维生素D3羟化酶基因的克隆表达和活性检测2.臂踝脉博波速度与骨质疏松症风险的相关性研究[D].苏州:苏州大学,2021. [30] Holick M F,Binkley N C,Bischoff-Ferrari H A,et al.Evaluation,treatment,and prevention of vitamin D deficiency:An endocrine society clinical practice guideline[J].The Journal of Clinical Endocrinology&Metabolism,2011,96(7):1911-1930. [31] 张妮,王丽娟.维生素D与慢性病的剂量-效应关系[J/OL].卫生研究,1-8[2025-11-17].https://link.cnki.net/urlid/11.2158.R.20251024.1131.002. [32] Altomonte I,Salari F,Licitra R,et al.Donkey and human milk:Insights into their compositional similarities[J].International Dairy Journal,2019,89:111-118. [33] Vici G,Camilletti D,Polzonetti V.Possible role of vitamin D in celiac disease onset[J].Nutrients,2020,12(4):1051. [34] 张积荣,王骁,李佳豪,等.补饲对放牧条件下哺乳期马驹生长发育的影响[J].安徽农业科学,2020,48(9):109-112. [35] 贾雨欣. 补喂支链氨基酸对伊犁马泌乳性能及血液指标的影响[D].乌鲁木齐:新疆农业大学,2024. [36] Rivero M J,Cooke A S,Gandarillas M,et al.Nutritional composition,fatty acids profile and immunoglobulin G concentrations of mare milk of the Chilean Corralero horse breed[J].Public Library of Science ONE,2024,19(9):e0310693. [37] Czyżak-Runowska G,Wójtowski J A,Danków R,et al.Mare's milk from a small polish specialized farm-basic chemical composition,fatty acid profile,and healthy lipid indices[J].Animals(Basel),2021,11(6):1590. [38] Toishimanov M,Zhanten O,Kanat R,et al.The effects of the lactation period,mare age,and foaling on the chemical and physical composition of milk from kazakh mares kept under natural pasture conditions[J].Animals(Basel),2025,15(12):1817. [39] Barłowska J,Polak G,Janczarek I,et al.The Influence of selected factors on the nutritional value of the milk of Cold-Blooded mares:the example of the Sokólski Breed[J].Animals(Basel),2023,13(7):1152. [40] 孙天松. 中国新疆地区传统发酵酸马奶的化学组成及乳酸菌生物多样性研究[D].呼和浩特:内蒙古农业大学,2006. [41] 红梅,包艳青,芒来,等.内蒙古地区传统发酵酸马奶不同发酵时期乳清蛋白SDS-PAGE分析[J].畜牧与饲料科学,2023,44(5):83-92. [42] Lou X,Shao W,Wu Y,et al.Peptidomic analysis of potential bioactive peptides in mare milk under different heat treatment conditions[J].Foods,2024,13(22):3592. [43] Gantner V,Baban M,Hanžek D,et al.Human and mare's milk-protein fraction and lipid composition[J].Poljoprivreda,2014,20(2):36-42. [44] Semenova E S,Simonenko E S,Manuylov B M.Structure and properties of a-lactalbumin in Mare's milk[J].Food Processing Industry,2022: 22-24. [45] Wodas L,Mackowski M,Borowska A,et al.Genes encoding equineβ-lactoglobulin(LGB1 and LGB2):Polymorphism,expression,and impact on milk composition[J].Public Library of Science ONE,2020,15(4):e0232066. [46] Kanda A,Nakayama K,Fukasawa T,et al.Post-exercise whey protein hydrolysate supplementation induces a greater increase in muscle protein synthesis than its constituent amino acid content[J].British Journal of Nutrition,2013,110(6):981-987. [47] Phillips S M.The impact of protein quality on the promotion of resistance exercise-induced changes in muscle mass[J].Nutrition&Metabolism,2016,13:1-9. [48] Qi X,Chen H,Guan K,et al.Identification,inhibitory mechanism and transepithelial transport of xanthine oxidase inhibitory peptides from whey protein after simulated gastrointestinal digestion and intestinal absorption[J].Food Research International,2022,162(Pt A):111959. [49] Luhovyy B L,Akhavan T,Anderson G H.Whey proteins in the regulation of food intake and satiety[J].Journal of the American College of Nutrition,2007,26(6):704S-712S. [50] Arendse L B,Danser A J,Pogitsch M,et al.Novel therapeutic approaches targeting the renin-angiotensin system and associated peptides in hypertension and heart failure[J].Pharmacological Reviews,2019,71(4):539-570. [51] 王磊,成雪,毛学英.乳清蛋白及其活性多肽的生物学功能研究进展[J].中国农业科技导报,2010,12(5):30-35. [52] 田志琴. 乳清蛋白的特性及在乳制品生产中的应用[J].中国食品工业,2022(23):86-88. [53] 王晔,王若男,刘双,等.乳清蛋白在运动营养中的功效研究进展[J].中国乳品工业,2024,52(12):45-52,58. [54] Faubladier C,Julliand V,Daneiche L,et al.Comparative fibre-degrading capacity in foals at immediate and late post-weaning periods[J].Animal,2017,11(9):1497-1504. [55] Musaev A,Sadykova S,Anambayeva A,et al.Mare’s milk:composition,properties,and application in medicine[J].Archives of Razi Institute,2021,76(4):1125. [56] Ma Y,Zhang L,Wu Y,et al.Changes in milk fat globule membrane proteome after pasteurization in human,bovine and caprine species[J].Food Chemistry,2019,279:209-215. [57] Lv K,Yang Y,Li Q,et al.Identification and comparison of milk fat globule membrane and whey proteins from Selle Français,Welsh pony,and Tieling Draft horse mare's milk[J].Food Chemistry,2024,437(Pt 2):137915. [58] Lv K,Yang Y,Li Q,et al.Identification and comparison of milk fat globule membrane and whey proteins from Selle Français,Welsh pony,and Tieling Draft horse mare’s milk[J].Food Chemistry,2024,437:137915. [59] Nie C,Zhao Y,Wang X,et al.Structure,biological functions,separation,properties,and potential applications of milk fat globule membrane(MFGM):A review[J].Nutrients,2024,16(5)587. [60] 王煜林,吉日木图,何静.乳脂球膜中的营养成分在婴儿健康和发育中的作用[J].中国食品学报,2023,23(6):402-410. [61] Agostoni C,Braegger C,Decsi T,et al.Breast-feeding:a commentary by the ESPGHAN committee on nutrition[J].Journal of Pediatric Gastroenterology and Nutrition,2009,49(1):112-125. [62] 阳菊红. 多聚唾液酸修饰对神经细胞粘附分子介导的信号通路的影响[D].西安:西北大学,2021. [63] 郭晋红,段昊,王点点,等.乳脂肪球膜功能特性的研究进展[J].食品安全质量检测学报,2023,14(23):264-273. [64] Ten Bruggencate S J,Frederiksen P D,Pedersen S M,et al. Dietary milk-fat-globule membrane affects resistance to diarrheagenic Escherichia coli in healthy adults in a randomized,placebo-controlled,double-blind Study.J Nutr,2016,146(2):249-255. [65] 时佳,张海娇,赵锋,等.乳脂肪球膜结构、功能特性及其应用研究进展[J].乳业科学与技术,2025,48(1):46-52. [66] Novaković P,Huang Y Y,Lockerbie B,et al.Identification of escherichia coli f4ac-binding proteins in porcine milk fat globule membrane[J].Canadian Journal of Veterinary Research,2015,79(2):120-128. [67] 张璐,任佳琦,何强,等.基于主成分分析的不同乳中脂肪酸组成及含量的比较[J].现代食品科技,2025,41(6):190-197. [68] 潘俊宇,王斌,范荣波,等.蛋白质组学技术在不同物种乳掺假检测中的应用[J].现代食品科技,2023,39(12):328-335. [69] 胡娜,利佳炜,闫珍珍,等.蛋白质定量质谱技术及其在食品加工用酵母中的应用[J].食品科学,2023,44(3):12-21. [70] Chen X,Gulbahar K,Ding H,et al.Comparative analysis of proteomics and transcriptomics reveals novel mechanism underlying the antibacterial activity and immune-enhancing properties of horse milk[J].Frontiers in Nutrition,2025,12:1512669. [71] Lin J,Jing H,Wang J,et al.Effects of lysine and threonine on milk yield,amino acid metabolism,and fecal microbiota of Yili lactating mares[J].Frontiers in Veterinary Science,2024,11:1396053. [72] 布仁其其格,董超,包玉龙,等.利用宏转录组学技术分析酸马奶发酵过程中活性微生物功能基因表达的变化特征[J].畜牧与饲料科学,2024,45(4):1-9. [73] Curadi M C,Orlandi M,Greppi G,et al.Identification of protein fractions in mare's colostrum and milk[J].Milchwissenschaft,2000,55(8):446-449. [74] 许晶辉. 驴乳和马乳的营养成分及对肠道微生物的影响[D].西安:陕西师范大学,2020. [75] Fantuz F,Ferraro S,Todini L,et al.Distribution of calcium,phosphorus,sulfur,magnesium,potassium,and sodium in major fractions of donkey milk[J].Journal of Dairy Science,2020,103(10):8741-8749. [76] Xiao T,Zeng J,Zhao C,et al.Comparative analysis of protein digestion characteristics in human,cow,goat,sheep,mare,and camel milk under simulated infant condition[J].Journal of Agricultural and Food Chemistry,2023,71(41):15035-15047. [77] 许晶辉,王朝霞,张富新,等.驴乳和马乳蛋白质组分及其消化特性[J].乳业科学与技术,2020,43(5):1-7. [78] Blanco-Doval A,Azkargorta M,Iloro I,et al.Comparative proteomic analysis of the changes in mare milk associated with different lactation stages and management systems[J].Food Chemistry,2024,445:138766. [79] 赵雪妮. 阿巴嘎黑马与乌珠穆沁白马鲜马奶发酵前后品质特性比较分析[D].呼和浩特:内蒙古农业大学,2021. [80] 秀布松,满达,特木其乐,等.蒙医酸马奶疗法对儿童自闭症谱系障碍肠道菌群影响的研究进展[J].中国民族医药杂志,2024,30(12):51-54. [81] 李倩,李海,黄新新,等.鲜马乳与发酵酸马乳常规营养成分的比较分析[J].中国乳品工业,2022,50(7):19-23. [82] Semenova E,Simonenko E,Simonenko S,et al.Hydrolysates of mare's milk proteins.Immunochemical and physico-chemical characteristics[J].Food Systems,2024,7(3):466-472. [83] 金花,代丽君,高娃.酸马奶[J].中国乳品工业,1998,(4):16-17. [84] 宋园亮,李海燕,柳陈坚.乳酸菌治疗乳糖不耐受症的研究进展[J].中国微生态学杂志,2010,22(8):751-753. [85] 杨俊华,孔祥明,王洁,等.高效液相色谱法测定宁夏牛奶中β-乳球蛋白和α-乳白蛋白含量[J].食品安全质量检测学报,2025,16(22):293-298. [86] Shi Y-D,Sun G-Q,Zhang Z-G,et al.The chemical composition of human milk from Inner Mongolia of China[J].Food Chemistry,2011,127(3):1193-1198. [87] 胜利. 酸马奶发酵剂菌株的筛选及其发酵工艺优化[D].呼和浩特:内蒙古农业大学,2022. [88] Meng Y,Chen X,Sun Z,et al.Exploring core microbiota responsible for the production of volatile flavor compounds during the traditional fermentation of Koumiss[J].LWT-Food Science and Technology,2021,135:110049. [89] Man L-L,Xiang D-J.Characterization of a broad spectrum bacteriocin produced by Lactobacillus plantarum MXG-68 from Inner Mongolia traditional fermented koumiss[J].Folia Microbiologica,2019,64:821-834. [90] Suissa R,Oved R,Jankelowitz G,et al.Molecular genetics for probiotic engineering:dissecting lactic acid bacteria[J].Trends in Microbiology,2022,30(3):293-306. [91] Gao Z,Daliri E B,Wang J,et al.Inhibitory effect of lactic acid bacteria on foodborne pathogens:A review[J].Journal of Food Protection,2019,82(3):441-453. [92] 胡爱心,刘金松,许英蕾,等.乳酸菌抑菌作用机制的研究进展[J].动物营养学报,2021,33(12):6690-6698. [93] 王文婧,殷文政,冀昌龙.产抑菌活性物质菌株的筛选及其抑菌机理的研究[J].现代食品科技,2016,32(12):151-157. [94] 孟岳成,黃阮卿,陈杰,等.热处理对酸马奶中蛋白质稳定性的影响[J].中国食品学报,2022,22(12):174-180. [95] 敖其,王丹,包英姝,等.酸马奶对慢性胃炎患者临床症状的改善效果研究[J].中国乳品工业,2018,46(5):14-17. [96] Timakova R,Il'yukhina Y V,Startsev V.Evaluation of the balance of amino acid composition of dry mare's milk protein[J].Food Processing Industry,2023:16-21. [97] 黄雅琴,于海宁,沈生荣.马奶营养成分及其对心血管疾病的防治作用[J].现代医药卫生,2024,40(24):4294-4298. [98] Shaikh A,Mehta B,Jana A H.Chemistry,nutritional properties and application of Mare's milk:A review[J].Agricultural Reviews,2022,43(3):355-361. [99] 小美. 微胶囊化酸马奶粉制备工艺研究[D].通辽:内蒙古民族大学,2024. [100] Sarsembayev K S,Sinyavskiy Y A,Ibraimov Y.Use of powdered mare's milk in the production of specialized sports nutrition products[J].Experimental Biology,2021:78-87. [101] 王威. 生鲜马乳中乳铁蛋白及脂肪酸分析与应用研究[D].乌鲁木齐:新疆农业大学,2017. |
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