中国乳业 ›› 2026, Vol. 0 ›› Issue (6): 49-55.doi: 10.12377/1671-4393.26.06.06

• 反刍动物营养与健康养殖专题 • 上一篇    下一篇

多组学技术驱动下奶牛营养免疫精准调控研究进展

张文学   

  1. 利津县动物疫病预防控制中心,山东东营 257447
  • 出版日期:2026-06-25 发布日期:2026-07-22
  • 作者简介:张文学(1979-),男,山东利津人,本科,兽医师,研究方向为畜牧兽医。

Research Progress on Precision Regulation of Nutritional Immunity in Dairy Cows Driven by Multi-omics Technologies

ZHANG Wenxue   

  1. Lijin County Animal Disease Prevention and Control Center, Dongying Shandong 257447
  • Online:2026-06-25 Published:2026-07-22

摘要: 奶牛营养免疫调控是保障奶牛健康、提升生产性能的核心环节,精准营养干预已成为现代奶牛养殖的重要发展方向。多组学技术的快速发展,为解析奶牛营养与免疫之间的复杂调控机制提供了有效的工具。本文系统综述了多组学技术在奶牛肠道微生态与免疫互作、关键营养素的免疫调控机制、营养应激应对及精准营养方案制定等方面的应用进展,深入探讨了多组学技术在推动奶牛营养免疫精准调控中的核心作用,为奶牛健康养殖和产业高质量发展提供参考。

关键词: 多组学技术, 奶牛, 营养免疫, 精准调控, 调控机制

Abstract: The regulation of nutritional immunity in dairy cows is a core aspect of ensuring herd health and enhancing production performance, and precision nutritional intervention has become an important direction in modern dairy farming. The rapid development of multi-omics technologies has provided effective tools for deciphering the complex regulatory mechanisms between nutrition and immunity in dairy cows. This paper systematically reviewed the application progress of multi-omics technologies in areas such as intestinal microecology-immune interactions, immunoregulatory mechanisms of key nutrients, nutritional stress responses, and the formulation of precision nutritional strategies. It further explored the central role of multi-omics technologies in advancing precision regulation of nutritional immunity in dairy cows, offering a reference for healthy dairy farming and high-quality industry development.

Key words: multi-omics technologies, dairy cows, nutritional immunity, precision regulation, regulatory mechanisms

[1] Fabjanowska J,Kowalczuk-Vasilev E,Klebaniuk R,et al.N-3 polyunsaturated fatty acids as a nutritional support of the reproductive and immune system of cattle-a review[J]. Animals,2023,13(22):3589.
[2] Khan MZ,Liu S,Ma Y,et al.Overview of the effect of rumen-protected limiting amino acids (methionine and lysine) and choline on the immunity,antioxidative,and inflammatory status of periparturient ruminants[J]. Frontiers in Immunology,2022,13:1042895.
[3] Liu S,Yang L,Zhang Y,et al.Review of yeast culture concerning the interactions between gut microbiota and young ruminant animals[J]. Frontiers In Veterinary Science,2024,11:1335765.
[4] He Z,Dong H.The roles of short-chain fatty acids derived from colonic bacteria fermentation of non-digestible carbohydrates and exogenous forms in ameliorating intestinal mucosal immunity of young ruminants[J]. Frontiers in Immunology,2023,14:1291846.
[5] Lv W,Sha Y,Liu X,et al.Interaction between rumen epithelial miRNAs-microbiota-metabolites in response to cold-season nutritional stress in Tibetan sheep[J]. International Journal Of Molecular Sciences,2023,24(19):14489.
[6] Zhang Y,Thomas JP,Korcsmaros T,et al.Integrating multi-omics to unravel host-microbiome interactions in inflammatory bowel disease[J]. Cell Reports Medicine,2024,5(9):101738.
[7] Liu L,Wu P,Guo A,et al.Research progress on the regulation of production traits by gastrointestinal microbiota in dairy cows[J]. Frontiers In Veterinary Science,2023,10:1206347.
[8] Zhang K,He C,Wang L,et al.Compendium of 5810 genomes of sheep and goat gut microbiomes provides new insights into the glycan and mucin utilization[J]. Microbiome,2024,12(1):104.
[9] Shi J,Su H,He S,et al.Pan-genomic insights into rumen microbiome-mediated short-chain fatty acid production and regulation in ruminants[J]. Microorganisms,2025,13(6):1175.
[10] Yang W,Cong Y.Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases[J]. Cellular & Molecular Immunology,2021,18(4):866-877.
[11] Ouyang J,Wang M,Bu D,et al.Ruminal microbes exhibit a robust circadian rhythm and are sensitive to melatonin[J]. Frontiers In Nutrition,2021,8:760578.
[12] Wu W,Lu H,Cheng J,et al.Undernutrition disrupts cecal microbiota and epithelium interactions,epithelial metabolism,and immune responses in a pregnant sheep model[J]. Microbiology Spectrum,2023,11(2):e0532022.
[13] Huo W,Lin Y,Wang C,et al.Methionine and its derivatives in dairy cow nutrition:implications for intestinal barrier function,periparturient performance,and metabolic health[J]. Frontiers In Veterinary Science,2025,12:1664853.
[14] Xin Y,Ji H,Cho E,et al.Immune-enhancing effect of water-soluble beta-glucan derived from enzymatic hydrolysis of yeast glucan[J]. Biochemistry And Biophysics Reports,2022,30:101256.
[15] Sivinski S E,Mamedova L K,Rusk R A,et al.Development of an in vitro macrophage screening system on the immunomodulating effects of feed components[J]. Journal of Animal Science And Biotechnology,2020,11:89.
[16] Hu Q Y,Man J J,Luo J,et al.Early-life supplementation with mannan-rich fraction to regulate rumen microbiota,gut health,immunity,and growth performance in dairy goat kids[J]. Journal of Dairy Science,2024,107(11):9322-9333.
[17] Bi R,Abbas W,Li J,et al.Yeast β-glucan ameliorated Salmonella-induced gut impairment in broiler chickens by modulating gut microbiome[J]. International Journal of Biological Macromolecules,2025,319(Pt 4):145630.
[18] Li X,Yang X,Liu S,et al.Yeast culture improves growth,antioxidant status,immunity,and gut microbiota homeostasis in preweaning Holstein calves[J]. Frontiers In Veterinary Science,2025,12:1670912.
[19] Horneck Johnston C J H,Ledwith A E,Lundahl M L E,et al. Recognition of yeast β-glucan particles triggers immunometabolic signaling required for trained immunity[J]. iScience,2024,27(3):109030.
[20] Qi P,Wang L.Effect of adding yeast cultures to high-grain conditions on production performance,rumen fermentation profile,microbial abundance,and immunity in goats[J]. Animals,2024,14(12):1799.
[21] Yang X,Wen D,Liu Z,et al.Biofermentation of aquatic plants:potential novel feed ingredients for dairy cattle production[J]. Science of The Total Environment,2024,952:175955.
[22] Wang K,Xin Z,Chen Z,et al.Progress of conjugated linoleic acid on milk fat metabolism in ruminants and humans[J]. Animals,2023,13(21):3429.
[23] Fan H,Xia S,Xiang J,et al.Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity[J]. Nature,2023,623(7989):1034-1043.
[24] Zinkow A,Grodzicki W,Czerwińska M,et al.Molecular mechanisms linking omega-3 fatty acids and the gut-brain axis[J]. Molecules,2024,30(1):71.
[25] Yang C,Lan W,Ye S,et al.Transcriptomic analyses reveal the protective immune regulation of conjugated linoleic acids in sheep ruminal epithelial cells[J]. Frontiers In Physiology,2020,11:588082.
[26] Trans-vaccenic acid reprograms CD8+ T cells and enhances antitumor immunity[J]. Cancer Discovery,2023. DOI:10.1158/2159-8290.cd-rw2023-192.
[27] Xu B,Hou X,Wang M,et al.Fatty acids modulate the colorectal cancer immune microenvironment via regulating the interaction and transactivation of PPARα/δ and P53[J]. Cell Reports,2025,44(12):116623.
[28] Haile A,Oliveira D E,Boisclair Y R,et al.Potential involvement of peroxisome proliferator-activated receptors in the inhibition of mammary lipid synthesis during diet-induced milk fat depression[J]. Journal of Dairy Science,2025,108(2):2036-2044.
[29] Shen S,Yan G,Cao Y,et al.Dietary supplementation of n-3 PUFAs ameliorates LL37-induced rosacea-like skin inflammation via inhibition of TLR2/MyD88/NF-κB pathway[J]. Biomedicine & Pharmacotherapy,2022,157:114091.
[30] Liu X F,Shao J H,Liao Y T,et al.Regulation of short-chain fatty acids in the immune system[J]. Frontiers In Immunology,2023,14:1186892.
[31] Wang J,Zhao Q,Zhang S,et al.Microbial short chain fatty acids:Effective histone deacetylase inhibitors in immune regulation (Review)[J]. International Journal of Molecular Medicine,2026,57(1):16.
[32] Chen Y,Zhang J,Cui W,et al.CD36,a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate[J]. The Journal of Experimental Medicine,2022,219(6):e20211314.
[33] Dhar S,Sarkar T,Bose S,et al.FOXP3 transcriptionally activates fatty acid scavenger receptor CD36 in tumour-induced Treg cells[J]. Immunology,2025,174(3):296-309.
[34] Ma N,Wei G,Zhang H,et al.Cis-9,Trans-11 CLA alleviates lipopolysaccharide-induced depression of fatty acid synthesis by inhibiting oxidative stress and autophagy in bovine mammary epithelial cells[J]. Antioxidants,2021,11(1):55.
[35] Gebeyew K,Yang C,He Z,et al.Low-protein diets supplemented with methionine and lysine alter the gut microbiota composition and improve the immune status of growing lambs[J]. Applied Microbiology and Biotechnology,2021,105(21-22):8393-8410.
[36] Wu Y,Guo X,Zhao D,et al.Effect of methionine supplementation on serum metabolism and the rumen bacterial community of sika deer (Cervus nippon)[J]. Animals,2022,12(15):1950.
[37] Jiang Q,Galvão M C,Thanh L P,et al. Short-term feed restriction induces inflammation and an antioxidant response via cystathionine-β-synthase and glutathione peroxidases in ruminal epithelium from Angus steers[J]. Journal of Animal Science,2024,102:skae257.
[38] Tanner A R,Kennedy V C,Lynch C S,et al. In vivo investigation of ruminant placenta function and physiology-a review[J]. Journal Of Animal Science,2022,100(6):skac045.
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